Bone Density

Publication Title: 
Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Studies suggest that green tea polyphenols (GTP) or alphacalcidol is promising agent for preventing bone loss. Findings that GTP supplementation plus alphacalcidol administration increased bone mass via a decrease of oxidative stress and inflammation suggest a significant role of GTP plus alphacalcidol in bone health of patients with chronic inflammation. INTRODUCTION: Studies have suggested that green tea polyphenols (GTP) or alphacalcidol are promising dietary supplements for preventing bone loss in women.

Author(s): 
Shen, C.-L.
Yeh, J. K.
Cao, J. J.
Tatum, O. L.
Dagda, R. Y.
Wang, J.-S.
Publication Title: 
Journal of Cellular and Molecular Medicine

Beneficial effects of n-3 fatty acids (FA) on bone mineral density (BMD) have been reported in mice, rats and human beings, but the precise mechanisms involved have not been described. This study used the Fat-1 mouse, a transgenic model that synthesizes n-3 FA from n-6 FA to directly determine if outcome of bone health were correlated with n-3 FA. Ovariectomized (Ovx) and sham operated wild-type (WT) and Fat-1 mice were fed an AIN-93M diet containing 10% corn oil for 24 weeks. BMD was analysed by dual energy x-ray absorptiometry.

Author(s): 
Rahman, Md Mizanur
Bhattacharya, Arunabh
Banu, Jameela
Kang, Jing X.
Fernandes, Gabriel
Publication Title: 
The Journal of Nutritional Biochemistry

Osteoporosis and obesity remain a major public health concern through its associated fragility and fractures. Several animal models for the study of osteoporotic bone loss, such as ovariectomy (OVX) and denervation, require unique surgical skills and expensive set up. The challenging aspect of these age-associated diseases is that no single animal model exactly mimics the progression of these human-specific chronic conditions.

Author(s): 
Halade, Ganesh V.
Rahman, Md M.
Williams, Paul J.
Fernandes, Gabriel
Publication Title: 
BMC musculoskeletal disorders

BACKGROUND: Post-menopausal osteopenic women are at increased risk for skeletal fractures. Current osteopenia treatment guidelines include exercise, however, optimal exercise regimens for attenuating bone mineral density (BMD) loss, or for addressing other fracture-related risk factors (e.g. poor balance, decreased muscle strength) are not well-defined. Tai Chi is an increasingly popular weight bearing mind-body exercise that has been reported to positively impact BMD dynamics and improve postural control, however, current evidence is inconclusive.

Author(s): 
Wayne, Peter M.
Buring, Julie E.
Davis, Roger B.
Connors, Ellen M.
Bonato, Paolo
Patritti, Benjamin
Fischer, Mary
Yeh, Gloria Y.
Cohen, Calvin J.
Carroll, Danette
Kiel, Douglas P.
Publication Title: 
The Journal of Nutrition

Equol, a product of intestinal metabolism of daidzein, is chemically similar to estrogen (without the lipophilic moiety) and has higher estrogen receptor-beta binding affinity than its parent precursor. In 2004, a long-term, randomized controlled trial that characterized postmenopausal women by their equol-producing status showed stronger advantages to lumbar spine bone mineral density (BMD) in equol- compared with nonequol-producers. Subsequent studies have related equol status of participants to change in bone turnover markers or BMD in response to soy isoflavone interventions.

Author(s): 
Weaver, Connie M.
Legette, LeeCole L.
Publication Title: 
The Journal of Nutritional Biochemistry

The inverse relationship between fat in bone marrow and bone mass in the skeleton of aging subjects is well known. However, there is no precise therapy for the treatment of bone marrow adiposity. We investigated the ability of conjugated linoleic acid (CLA) and fish oil (FO), alone or in combination, to modulate bone loss using 12 months old C57Bl/6J mice fed 10% corn oil diet as control or supplemented with 0.5% CLA or 5% FO or 0.5% CLA+5% FO for 6 months.

Author(s): 
Halade, Ganesh V.
Rahman, Md M.
Williams, Paul J.
Fernandes, Gabriel
Publication Title: 
The Journal of Nutrition

(3)H-tetracycline ((3)H-TC) is thought to be superior to calcium (Ca) isotopic tracers for estimating bone resorption rates due to the less redeposition upon release in animal models. However, these 2 tracers have not been compared directly using complete kinetic studies with sampling of blood, urine, feces, and bone. Our goal was to compare the 2 isotopes for evaluating bone turnover. We firstly developed a model for (3)H-TC kinetics in 4-mo-old female rats (n = 3) by measuring the tracer in serum, urine, and feces over 4 d.

Author(s): 
Zhao, Yongdong
Cheong, Jennifer M. K.
Lee, WangHee
Wastney, Meryl
Martin, Berdine R.
Weaver, Connie M.
Publication Title: 
Annals of Internal Medicine

BACKGROUND: Previous studies comparing low-carbohydrate and low-fat diets have not included a comprehensive behavioral treatment, resulting in suboptimal weight loss. OBJECTIVE: To evaluate the effects of 2-year treatment with a low-carbohydrate or low-fat diet, each of which was combined with a comprehensive lifestyle modification program. DESIGN: Randomized parallel-group trial. (ClinicalTrials.gov registration number: NCT00143936) SETTING: 3 academic medical centers.

Author(s): 
Foster, Gary D.
Wyatt, Holly R.
Hill, James O.
Makris, Angela P.
Rosenbaum, Diane L.
Brill, Carrie
Stein, Richard I.
Mohammed, B. Selma
Miller, Bernard
Rader, Daniel J.
Zemel, Babette
Wadden, Thomas A.
Tenhave, Thomas
Newcomb, Craig W.
Klein, Samuel
Publication Title: 
Journal of Agricultural and Food Chemistry

Extracts prepared from turmeric (Curcuma longa L., [Zingiberaceae]) containing bioactive phenolic curcuminoids were evaluated for bone-protective effects in a hypogonadal rat model of postmenopausal osteoporosis. Three-month female Sprague-Dawley rats were ovariectomized (OVX) and treated with a chemically complex turmeric fraction (41% curcuminoids by weight) or a curcuminoid-enriched turmeric fraction (94% curcuminoids by weight), both dosed at 60 mg/kg 3x per week, or vehicle alone.

Author(s): 
Wright, Laura E.
Frye, Jennifer B.
Timmermann, Barbara N.
Funk, Janet L.
Publication Title: 
Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research

Bone mineral density (BMD) is an important factor linked to bone health. Little is known of the prevalence of low BMD and its associated risk factors in an urban underserved population. Between 2001 and 2004, we recruited 338 subjects who completed drug use and medical history questionnaires, underwent hormonal measurements, and underwent whole-body dual-energy X-ray absorptiometry (DXA) for evaluation of BMD and body composition. Of these, 132 subjects had site-specific DXA (lumbar spine and hip) performed.

Author(s): 
El-Maouche, Diala
Xu, Xiaoqiang
Cofrancesco, Joseph
Dobs, Adrian S.
Brown, Todd T.

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