Bone Density

Publication Title: 
The Journal of Nutrition

Soybeans are a good source of bone-healthy nutrients. Epidemiological studies in Asia evaluating diets containing traditional whole soy foods show a positive association with bone mineral density and fracture protection. Smaller scale intervention studies in Western nations mainly feature isolated soy protein (SP) and purified or concentrated soy isoflavones (SI) rather than whole soy foods and they have produced inconsistent results.

Author(s): 
Reinwald, Susan
Weaver, Connie M.
Publication Title: 
Journal of Hepatology

BACKGROUND & AIMS: To evaluate the prevalence and risk factors for low bone mineral density (BMD) in persons co-infected with HIV and Hepatitis C. METHODS: HIV/HCV co-infected study participants (n=179) were recruited into a prospective cohort and underwent dual-energy X-ray absorptiometry (DXA) within 1 year of a liver biopsy. Fibrosis staging was evaluated according to the METAVIR system. Osteoporosis was defined as a T-score ≤-2.5.

Author(s): 
El-Maouche, Diala
Mehta, Shruti H.
Sutcliffe, Catherine
Higgins, Yvonne
Torbenson, Michael S.
Moore, Richard D.
Thomas, David L.
Sulkowski, Mark S.
Brown, Todd T.
Publication Title: 
Nutrition Reviews

Conjugated linoleic acid (CLA) supplementation decreases adipose mass and increases bone mass in mice. Recent clinical studies demonstrate a beneficial effect of CLA on reducing weight and adipose mass in humans. This article reviews possible biological mechanisms of action of CLA on bone metabolism, focusing on modulation of nuclear receptor peroxisome proliferator-activated receptor gamma activity to steer mesenchymal stem cell differentiation toward an adipose and away from an osteoblast lineage.

Author(s): 
Ing, Steven W.
Belury, Martha A.
Publication Title: 
The Journal of the American Osteopathic Association

CONTEXT: Identifying objective measures that correlate with somatic dysfunction palpatory findings will aid in establishing clinical relevance of the findings and provide outcome measures for future studies. OBJECTIVE: To investigate the association of altered segmental lumbar vertebral mechanics (ie, somatic dysfunction) as assessed by palpation with bone mineral density (BMD) T-score variability in participants, some with chronic low back pain (CLBP) and others without low back pain (LBP).

Author(s): 
Snider, Karen T.
Johnson, Jane C.
Degenhardt, Brian F.
Snider, Eric J.
Publication Title: 
Pharmacological Research: The Official Journal of the Italian Pharmacological Society

Osteoporosis is a major health problem in the elderly. Epidemiological evidence has shown an association between tea consumption and the prevention of bone loss in the elderly population. Ingestion of green tea and green tea bioactive compounds may be beneficial in mitigating bone loss of this population and decreasing their risk of osteoporotic fractures.

Author(s): 
Shen, Chwan-Li
Yeh, James K.
Cao, Jay J.
Chyu, Ming-Chien
Wang, Jia-Sheng
Publication Title: 
Menopause (New York, N.Y.)

OBJECTIVE: Prebiotics and phytoestrogens have sparked great interest because evidence indicates that the consumption of these dietary constituents leads to lower cholesterol levels and inhibition of postmenopausal bone loss. The aim of this study was to determine the effect of both a prebiotic (Synergy) and a phytoestrogen (genistein) on bone and blood lipid levels in an animal model of postmenopausal women.

Author(s): 
Legette, LeeCole L.
Lee, Wang-Hee
Martin, Berdine R.
Story, Jon A.
Arabshahi, Ali
Barnes, Stephen
Weaver, Connie M.
Publication Title: 
Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

People with both HIV and hepatitis C are more likely than those with HIV alone to have wrist, hip, and spine fractures. We compared hip strength between HIV/HCV-co-infected men and healthy men and found that HIV/HCV-co-infected men had decreased hip strength due to lower lean body mass. INTRODUCTION: Hepatitis C co-infection is a risk factor for fragility fracture among HIV-infected populations. Whether bone strength is compromised in HIV/HCV-co-infected patients is unknown.

Author(s): 
Walker Harris, V.
Sutcliffe, C. G.
Araujo, A. B.
Chiu, G. R.
Travison, T. G.
Mehta, S.
Sulkowski, M. S.
Higgins, Y.
Thomas, D. L.
Dobs, A. S.
Beck, T. J.
Brown, T. T.
Publication Title: 
Antiviral Therapy

BACKGROUND: Bone mineral density decreases with antiretroviral therapy (ART) initiation, although the pathogenesis, including the role of tenofovir (TDF), is unclear. This study assessed changes in bone-turnover markers, osteoprotegerin (OPG), soluble receptor activator for nuclear factor-κβ ligand (sRANKL), and inflammation in subjects initiating TDF- versus non-TDF-containing regimens, and determined the relationship between bone turnover, OPG/sRANKL and inflammation.

Author(s): 
Brown, Todd T.
Ross, Allison C.
Storer, Norma
Labbato, Danielle
McComsey, Grace A.
Publication Title: 
Calcified Tissue International

Bone loss during perimenopause, an estrogen-sufficient period, correlates with elevated serum follicle-stimulating hormone (FSH) and decreased inhibins A and B. Utilizing a recently described ovotoxin-induced animal model of perimenopause characterized by a prolonged estrogen-replete period of elevated FSH, we examined longitudinal changes in bone mineral density (BMD) and their association with FSH.

Author(s): 
Lukefahr, A. L.
Frye, J. B.
Wright, L. E.
Marion, S. L.
Hoyer, P. B.
Funk, J. L.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Tai Chi (TC) is a mind-body exercise that shows potential as an effective and safe intervention for preventing fall-related fractures in the elderly. Few randomized trials have simultaneously evaluated TC's potential to reduce bone loss and improve fall-predictive balance parameters in osteopenic women. METHODS: In a pragmatic randomized trial, 86 post-menopausal osteopenic women, aged 45-70, were recruited from community clinics. Women were assigned to either nine months of TC training plus usual care (UC) vs. UC alone.

Author(s): 
Wayne, Peter M.
Kiel, Douglas P.
Buring, Julie E.
Connors, Ellen M.
Bonato, Paolo
Yeh, Gloria Y.
Cohen, Calvin J.
Mancinelli, Chiara
Davis, Roger B.

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