Bone Density

Publication Title: 
Antiviral Therapy

BACKGROUND: Lipoatrophy modestly improves when the thymidine analogue nucleoside reverse transcriptase inhibitor (tNRTI) is removed. In vitro, uridine (NucleomaxX(®); Pharma Nord, Vojens, Denmark) reversed tNRTI mitochondrial toxicity. METHODS: All patients had lipoatrophy on a tNRTI-containing regimen with HIV RNA<400 copies/ml. A randomized 48-week study switched patients from tNRTI to tenofovir (TDF) or added uridine (continuing tNRTI).

Author(s): 
McComsey, Grace A.
O'Riordan, MaryAnn
Choi, Julia
Libutti, Daniel
Rowe, David
Storer, Norma
Harrill, Danielle
Gerschenson, Mariana
Publication Title: 
Menopause (New York, N.Y.)

OBJECTIVE: Estrogen deficiency after menopause results in rapid bone loss, predisposing women to osteoporotic fractures. Genistein, a phytoestrogen present in high concentrations in soy, is an ingredient in dietary supplements aggressively marketed for bone health. However, in a recent long-duration clinical trial in postmenopausal women, the efficacy of soy extracts in reducing bone loss was disappointing.

Author(s): 
Turner, Russell T.
Iwaniec, Urszula T.
Andrade, Juan E.
Branscum, Adam J.
Neese, Steven L.
Olson, Dawn A.
Wagner, Lindsay
Wang, Victor C.
Schantz, Susan L.
Helferich, William G.
Publication Title: 
Journal of Cellular Physiology

Osteoporosis can result from intestinal inflammation, as is seen with inflammatory bowel disease. Probiotics, microorganisms that provide a health benefit to the host when ingested in adequate amounts, can have anti-inflammatory properties and are currently being examined to treat inflammatory bowel disease. Here, we examined if treating healthy male mice with Lactobacillus reuteri ATCC PTA 6475 (a candidate probiotic with anti-TNFα activity) could affect intestinal TNFα levels and enhance bone density. Adult male mice were given L. reuteri 6475 orally by gavage for 3×/week for 4 weeks.

Author(s): 
McCabe, Laura R.
Irwin, Regina
Schaefer, Laura
Britton, Robert A.
Publication Title: 
Molecular Endocrinology (Baltimore, Md.)

Extensive evidence has suggested that at least some of the effects of estrogens on bone are mediated via extranuclear estrogen receptor α signaling. However, definitive proof for this contention and the extent to which such effects may contribute to the overall protective effects of estrogens on bone maintenance have remained elusive. Here, we investigated the ability of a 17β-estradiol (E2) dendrimer conjugate (EDC), incapable of stimulating nuclear-initiated actions of estrogen receptor α, to prevent the effects of ovariectomy (OVX) on the murine skeleton.

Author(s): 
Bartell, Shoshana M.
Han, Li
Kim, Ha-neui
Kim, Sung Hoon
Katzenellenbogen, John A.
Katzenellenbogen, Benita S.
Chambliss, Ken L.
Shaul, Philip W.
Roberson, Paula K.
Weinstein, Robert S.
Jilka, Robert L.
Almeida, Maria
Manolagas, Stavros C.
Publication Title: 
PloS One

Interest in dried plum has increased over the past decade due to its promise in restoring bone and preventing bone loss in animal models of osteoporosis. This study compared the effects of dried plum on bone to other dried fruits and further explored the potential mechanisms of action through which dried plum may exert its osteoprotective effects. Adult osteopenic ovariectomized (OVX) C57BL/6 mice were fed either a control diet or a diet supplemented with 25% (w/w) dried plum, apple, apricot, grape or mango for 8 weeks.

Author(s): 
Rendina, Elizabeth
Hembree, Kelsey D.
Davis, McKale R.
Marlow, Denver
Clarke, Stephen L.
Halloran, Bernard P.
Lucas, Edralin A.
Smith, Brenda J.
Publication Title: 
Food Chemistry

Osteoporosis is a significant health concern for the elderly; conjugated linoleic acid (CLA) has been shown to improve overall bone mass when calcium is included as a co-supplement. However, potential effects of CLA and calcium on bone mass during a period of bone loss have not been reported. The purpose of this study was to determine how dietary calcium modulates the effects of conjugated linoleic acid (CLA) in preventing bone loss, using an ovariectomised mouse model.

Author(s): 
Park, Yooheon
Kim, Jonggun
Scrimgeour, Angus G.
Condlin, Michelle L.
Kim, Daeyoung
Park, Yeonhwa
Publication Title: 
Inflammatory Bowel Diseases

BACKGROUND: Patients with inflammatory bowel disease (IBD) are at increase risk for bone loss and fractures. Therefore, in the present study, we examined the effect of experimental IBD on bone health. METHODS: We used a murine model of colitis, Helicobacter hepaticus-infected interleukin-10-deficient animals. Molecular and histological properties of bone and intestine were examined to identify the immunopathological consequences of colitis in male and female mice.

Author(s): 
Irwin, Regina
Lee, Taehyung
Young, Vincent B.
Parameswaran, Narayanan
McCabe, Laura R.
Publication Title: 
Journal of Musculoskeletal & Neuronal Interactions

The objects of this study were to investigate the effects of massage therapy during early life on postnatal growth, body composition, and skeletal development in juvenile and young adult rats. Massage therapy was performed for 10 minutes daily from D6 to D10 of postnatal life in rat pups (MT, n=24).

Author(s): 
Chen, H.
Miller, S.
Shaw, J.
Moyer-Mileur, L.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The effect of massage therapy on bone metabolism in adults has only scarcely been explored. In a randomized crossover trial, we investigated the skeletal effect of Thai traditional massage by examining the changes in biochemical markers of bone turnover. METHODS: Forty-eight postmenopausal women participated in the study. All volunteers were randomized to a 2-hour session of Thai traditional massage twice a week for 4 weeks and a 4-week control period after a 2-week washout, or vice versa.

Author(s): 
Saetung, Sunee
Chailurkit, La-Or
Ongphiphadhanakul, Boonsong
Publication Title: 
Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine / Zhongguo Zhong Xi Yi Jie He Xue Hui, Zhongguo Zhong Yi Yan Jiu Yuan Zhu Ban

OBJECTIVE: To observe the effects of comprehensive therapy on serum secreted protein acidic and rich in cysteine (SPARC) levels in ankylosing spondylitis (AS) patients accompanied with osteoporosis (OP), and to explore the possible mechanisms for SPARC in AS patients accompanied with osteoporosis. METHODS: Totally 48 AS patients accompanied with OP (Group A) were treated with massage, intravenous infusion of Cervus and Cucumis Polypeptide Injection, and Bushen Quhan Zhiwang Decoction (BQZD) for 3 months.

Author(s): 
Xu, Jing-ren
Lin, Yan
Zhang, Chun-Yan
Li, Wei-min
Guo, Chen-Jun
Ye, Lei

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