Bone Density

Publication Title: 
Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research

A higher calcium intake is still the primary recommendation for the prevention of osteoporosis, whereas vitamin D deficiency is often not addressed. To study the relative importance of dietary calcium intake and serum 25-hydroxyvitamin D [25(OH)D] status in regard to hip BMD, 4958 community-dwelling women and 5003 men >/=20 yr of age from the U.S. NHANES III population-based survey were studied. Calcium supplement users and individuals with a prior radius or hip fracture were excluded.

Author(s): 
Bischoff-Ferrari, Heike A.
Kiel, Douglas P.
Dawson-Hughes, Bess
Orav, John E.
Li, Ruifeng
Spiegelman, Donna
Dietrich, Thomas
Willett, Walter C.
Publication Title: 
Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Vitamin C may play a role in bone health. In the Framingham Study, subjects with higher total or supplemental vitamin C intake had fewer hip fractures and non-vertebral fractures as compared to subjects with lower intakes. Therefore, vitamin C may have a protective effect on bone health in older adults. INTRODUCTION: Dietary antioxidants such as vitamin C may play a role in bone health.

Author(s): 
Sahni, S.
Hannan, M. T.
Gagnon, D.
Blumberg, J.
Cupples, L. A.
Kiel, D. P.
Tucker, K. L.
Publication Title: 
The Journal of Nutrition

Calcium (Ca) supplements, especially Ca carbonate (CaCO3), are the main alternative sources of dietary Ca and an important part of a treatment regimen for osteoporosis, the most common metabolic bone disorder of aging and menopause. In a female ovariectomized (OVX) rat model for studying postmenopausal osteoporosis, we tested the hypothesis that a small compared with a large particle size of CaCO3 (13.0- vs. 18.5-mum geometric diameter) would result in increased Ca balance and subsequently bone mass and that this would be affected by dietary Ca level.

Author(s): 
Shahnazari, Mohammad
Martin, Berdine R.
Legette, LeeCole L.
Lachcik, Pamela J.
Welch, Jo
Weaver, Connie M.
Publication Title: 
BMC musculoskeletal disorders

BACKGROUND: Osteoporosis is a major health problem in postmenopausal women. Evidence suggests the importance of oxidative stress in bone metabolism and bone loss. Tea consumption may be beneficial to osteoporosis due to its antioxidant capability. However, lack of objective data characterizing tea consumption has hindered the precise evaluation of the association between tea ingestion and bone mineral density in previous questionnaire-based epidemiological studies.

Author(s): 
Shen, Chwan-Li
Chyu, Ming-Chien
Yeh, James K.
Felton, Carol K.
Xu, Ke T.
Pence, Barbara C.
Wang, Jia-Sheng
Publication Title: 
The Journal of Nutritional Biochemistry

The inverse relationship between fat in bone marrow and bone mass in the skeleton of aging subjects is well known. However, there is no precise therapy for the treatment of bone marrow adiposity. We investigated the ability of conjugated linoleic acid (CLA) and fish oil (FO), alone or in combination, to modulate bone loss using 12 months old C57Bl/6J mice fed 10% corn oil diet as control or supplemented with 0.5% CLA or 5% FO or 0.5% CLA+5% FO for 6 months.

Author(s): 
Halade, Ganesh V.
Rahman, Md M.
Williams, Paul J.
Fernandes, Gabriel
Publication Title: 
The Journal of Nutrition

Although vitamin D deficiency is common at birth, the consequences to growth and bone mass by weaning are unclear. This study was designed to determine whether maternal dietary vitamin D deficiency in pregnancy has a negative impact on the bone mass of full-term neonates and if postnatal supplementation could restore bone mass. Forty guinea pigs were randomized to receive a control (C) or deficient (D) diet (0.03 microg vs. 0.00 microg cholecalciferol/g) during pregnancy.

Author(s): 
Finch, Sarah L.
Rauch, Frank
Weiler, Hope A.
Publication Title: 
Menopause (New York, N.Y.)

OBJECTIVE: Prebiotics and phytoestrogens have sparked great interest because evidence indicates that the consumption of these dietary constituents leads to lower cholesterol levels and inhibition of postmenopausal bone loss. The aim of this study was to determine the effect of both a prebiotic (Synergy) and a phytoestrogen (genistein) on bone and blood lipid levels in an animal model of postmenopausal women.

Author(s): 
Legette, LeeCole L.
Lee, Wang-Hee
Martin, Berdine R.
Story, Jon A.
Arabshahi, Ali
Barnes, Stephen
Weaver, Connie M.
Publication Title: 
Trials

MAVIDOS is a randomised, double-blind, placebo-controlled trial (ISRCTN82927713, registered 2008 Apr 11), funded by Arthritis Research UK, MRC, Bupa Foundation and NIHR. BACKGROUND: Osteoporosis is a major public health problem as a result of associated fragility fractures. Skeletal strength increases from birth to a peak in early adulthood. This peak predicts osteoporosis risk in later life. Vitamin D insufficiency in pregnancy is common (31% in a recent Southampton cohort) and predicts reduced bone mass in the offspring.

Author(s): 
Harvey, Nicholas C.
Javaid, Kassim
Bishop, Nicholas
Kennedy, Stephen
Papageorghiou, Aris T.
Fraser, Robert
Gandhi, Saurabh V.
Schoenmakers, Inez
Prentice, Ann
Cooper, Cyrus
Publication Title: 
The Oncologist

BACKGROUND: Loss of bone mineral density is an unintended consequence of androgen deprivation therapy in men with prostate cancer. Supplementation with calcium and/or vitamin D in these men seems logical and is advocated by many lay and professional groups. METHODS: We reviewed guidelines for calcium and vitamin D supplementation and the results of clinical trials of calcium and vitamin D supplementation on bone mineral density in men with prostate cancer undergoing androgen deprivation therapy.

Author(s): 
Datta, Mridul
Schwartz, Gary G.
Publication Title: 
Menopause (New York, N.Y.)

OBJECTIVE: Estrogen deficiency after menopause results in rapid bone loss, predisposing women to osteoporotic fractures. Genistein, a phytoestrogen present in high concentrations in soy, is an ingredient in dietary supplements aggressively marketed for bone health. However, in a recent long-duration clinical trial in postmenopausal women, the efficacy of soy extracts in reducing bone loss was disappointing.

Author(s): 
Turner, Russell T.
Iwaniec, Urszula T.
Andrade, Juan E.
Branscum, Adam J.
Neese, Steven L.
Olson, Dawn A.
Wagner, Lindsay
Wang, Victor C.
Schantz, Susan L.
Helferich, William G.

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