Bone Development

Publication Title: 
Annual Review of Nutrition

Increased longevity and improved medical management of children with chronic illnesses has led to a focus on the short- and long-term consequences of these conditions on bone health. Bone loss is influenced by diet, malabsorption, and disease-related imbalances in bone turnover. It may be exacerbated by common medications, especially corticosteroids.

Author(s): 
Abrams, S. A.
O'Brien, K. O.
Publication Title: 
The Journal of Nutrition

Evidence of the effect of purified soy isoflavones and soy protein isolates containing isoflavones on bone health in rats and in humans is inconsistent. Differences may be because of synergies or antagonisms among the isoflavones, threshold or biphasic dose effects, life stage of animals or human subjects, estrogen status, and environment-genetic interactions, including the ability to produce metabolites upon ingestion of isoflavones. At this time, the benefits of soy protein and isoflavones on bone health are inconclusive.

Author(s): 
Weaver, Connie M.
Cheong, Jennifer M. K.
Publication Title: 
The Journal of Nutrition

Consumption of green tea may reduce body weight gain. Although many disorders are related to obesity, bone mass is positively correlated with body mass. Therefore, our purpose in this study was to determine the effects of green tea extract (GTE) on bone mass and architecture in rapidly growing lean [C57BL/6 wild type (WT)] and genetically obese, leptin-deficient (ob/ob) male mice. Five-week-old lean and ob/ob mice were assigned to diets containing GTE at 0, 1, or 2% for 6 wk. Femoral and lumbar vertebral bone volume and architecture were evaluated by micro-computed tomography (muCT).

Author(s): 
Iwaniec, Urszula T.
Turner, Russell T.
Koo, Sung I.
Kaur, Rouminder
Ho, Emily
Wong, Carmen P.
Bruno, Richard S.
Publication Title: 
Journal of Musculoskeletal & Neuronal Interactions

OBJECTIVES: Neonatal stress impairs postnatal bone mineralization. Evidence suggests that mechanical tactile stimulation (MTS) in early life decreases stress hormones and improves bone mineralization. Insulin-like growth factor (IGF1) is impacted by stress and essential to bone development. We hypothesized that MTS administered during neonatal stress would improve bone phenotype in later life. We also predicted an increase in bone specific mRNA expression of IGF1 related pathways.

Author(s): 
Haley, S.
O'Grady, S.
Gulliver, K.
Bowman, B.
Baldassarre, R.
Miller, S.
Lane, R. H.
Moyer-Mileur, L. J.
Publication Title: 
The Journal of Nutritional Biochemistry

The bone undergoes continuous remodeling of osteoblastic bone formation and osteoclastic bone resorption to maintain proper bone mass. It is also reported that bone marrow adiposity has a reciprocal role in osteoblasts due to their same origin from mesenchymal stem cells. In addition, one of the key mediators of adipogenesis, peroxisome-proliferator activated receptor-γ (PPARγ), plays a significant role in osteoblastogenesis in bone marrow mesenchymal stem cells. One dietary component that is known to have significant impact on adiposity and bone mass is conjugated linoleic acid (CLA).

Author(s): 
Kim, Jonggun
Park, Yooheon
Lee, Seong-Ho
Park, Yeonhwa
Publication Title: 
Journal of Musculoskeletal & Neuronal Interactions

OBJECTIVES: Preterm infants are born with low bone mineral. Neonatal stress further impedes bone mineralization. Clinical evidence suggests that tactile and kinesthetic stimulation (TKS) improves bone phenotype and decreases stress response. Clinical and translational studies indicate the IGF-1 axis, responsible for postnatal growth and bone mineralization, is a key player. We hypothesized that TKS would attenuate the negative impact of neonatal stress on bone phenotype and the IGF-1 axis in weanling rats.

Author(s): 
Haley, S.
Gulliver, K.
Baldassarre, R.
Miller, S.
Lane, R. H.
Moyer-Mileur, L. J.
Publication Title: 
Arthritis & Rheumatology (Hoboken, N.J.)

OBJECTIVE: The C-type natriuretic peptide (CNP) signaling pathway is a major contributor to postnatal skeletal growth in humans. This study was undertaken to investigate whether CNP signaling could prevent growth delay and cartilage damage in an animal model of inflammatory arthritis. METHODS: We generated transgenic mice that overexpress CNP (B6.SJL-Col2a1-NPPC) in chondrocytes.

Author(s): 
Bükülmez, Hülya
Khan, Fozia
Bartels, Cynthia F.
Murakami, Shunichi
Ortiz-Lopez, Adriana
Sattar, Abdus
Haqqi, Tariq M.
Warman, Matthew L.
Publication Title: 
Hu Li Za Zhi The Journal of Nursing

Massage therapy has been used in the care of premature infants for many years in western countries, and a significant body of research has already shown the effectiveness of massage therapy in significantly increasing body weight, decreasing infant hospital durations, enhancing bone formation, and improving behavior. Key considerations when applying massage therapy on premature infants include gestational age, bodyweight, and physical condition. Nurses can teach parents to administer massage therapy on their premature infants to enhance parent-child attachment and interaction.

Author(s): 
Chang, Shu-Min
Sung, Huei-Chuan
Publication Title: 
Journal of Musculoskeletal & Neuronal Interactions

The objects of this study were to investigate the effects of massage therapy during early life on postnatal growth, body composition, and skeletal development in juvenile and young adult rats. Massage therapy was performed for 10 minutes daily from D6 to D10 of postnatal life in rat pups (MT, n=24).

Author(s): 
Chen, H.
Miller, S.
Shaw, J.
Moyer-Mileur, L.
Publication Title: 
Upsala Journal of Medical Sciences

The increasing incidence of postmenopausal osteoporosis and its related fractures have become global health issues in the recent days. Postmenopausal osteoporosis is the most frequent metabolic bone disease; it is characterized by a rapid loss of mineralized bone tissue. Hormone replacement therapy has proven efficacious in preventing bone loss but not desirable to many women due to its side-effects. Therefore we are in need to search the natural compounds for a treatment of postmenopausal symptoms in women with no toxic effects.

Author(s): 
Potu, Bhagath K.
Rao, Muddanna S.
Nampurath, Gopalan K.
Chamallamudi, Mallikarjuna R.
Prasad, Keerthana
Nayak, Soubhagya R.
Dharmavarapu, Praveen K.
Kedage, Vivekananda
Bhat, Kumar M. R.

Pages

Subscribe to RSS - Bone Development