Bone Diseases, Metabolic

Publication Title: 
Phytotherapy research: PTR

Bone metabolism involves a complex balance between the deposition of matrix and mineralization and resorption. There is now good evidence that dietary components and herbal products can influence these processes, particularly by inhibiting bone resorption, thus having beneficial effects on the skeleton. For example, it has been reported that a number of common vegetables, including onion, garlic and parsley, can inhibit bone resorption in ovariectomized rats.

Author(s): 
Putnam, Sophie E.
Scutt, Andy M.
Bicknell, Katrina
Priestley, Caroline M.
Williamson, Elizabeth M.
Publication Title: 
Pain Practice: The Official Journal of World Institute of Pain

OBJECTIVE: The objective of this report is to raise awareness of the effect of strenuous yoga flexion exercises on osteopenic or osteoporotic spines. We previously described subjects with known osteoporosis in whom vertebral compression fractures (VCFs) developed after spinal flexion exercise (SFE) and recommended that SFEs not be prescribed in patients with spinal osteoporosis. METHODS: This report describes 3 healthy persons with low bone mass and yoga-induced pain or fracture.

Author(s): 
Sinaki, Mehrsheed
Publication Title: 
The Journal of Nutrition

Consumption of green tea may reduce body weight gain. Although many disorders are related to obesity, bone mass is positively correlated with body mass. Therefore, our purpose in this study was to determine the effects of green tea extract (GTE) on bone mass and architecture in rapidly growing lean [C57BL/6 wild type (WT)] and genetically obese, leptin-deficient (ob/ob) male mice. Five-week-old lean and ob/ob mice were assigned to diets containing GTE at 0, 1, or 2% for 6 wk. Femoral and lumbar vertebral bone volume and architecture were evaluated by micro-computed tomography (muCT).

Author(s): 
Iwaniec, Urszula T.
Turner, Russell T.
Koo, Sung I.
Kaur, Rouminder
Ho, Emily
Wong, Carmen P.
Bruno, Richard S.
Publication Title: 
BMC musculoskeletal disorders

BACKGROUND: Osteoporosis is a major health problem in postmenopausal women. Evidence suggests the importance of oxidative stress in bone metabolism and bone loss. Tea consumption may be beneficial to osteoporosis due to its antioxidant capability. However, lack of objective data characterizing tea consumption has hindered the precise evaluation of the association between tea ingestion and bone mineral density in previous questionnaire-based epidemiological studies.

Author(s): 
Shen, Chwan-Li
Chyu, Ming-Chien
Yeh, James K.
Felton, Carol K.
Xu, Ke T.
Pence, Barbara C.
Wang, Jia-Sheng
Publication Title: 
Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Studies suggest that green tea polyphenols (GTP) or alphacalcidol is promising agent for preventing bone loss. Findings that GTP supplementation plus alphacalcidol administration increased bone mass via a decrease of oxidative stress and inflammation suggest a significant role of GTP plus alphacalcidol in bone health of patients with chronic inflammation. INTRODUCTION: Studies have suggested that green tea polyphenols (GTP) or alphacalcidol are promising dietary supplements for preventing bone loss in women.

Author(s): 
Shen, C.-L.
Yeh, J. K.
Cao, J. J.
Tatum, O. L.
Dagda, R. Y.
Wang, J.-S.
Publication Title: 
BMC musculoskeletal disorders

BACKGROUND: Post-menopausal osteopenic women are at increased risk for skeletal fractures. Current osteopenia treatment guidelines include exercise, however, optimal exercise regimens for attenuating bone mineral density (BMD) loss, or for addressing other fracture-related risk factors (e.g. poor balance, decreased muscle strength) are not well-defined. Tai Chi is an increasingly popular weight bearing mind-body exercise that has been reported to positively impact BMD dynamics and improve postural control, however, current evidence is inconclusive.

Author(s): 
Wayne, Peter M.
Buring, Julie E.
Davis, Roger B.
Connors, Ellen M.
Bonato, Paolo
Patritti, Benjamin
Fischer, Mary
Yeh, Gloria Y.
Cohen, Calvin J.
Carroll, Danette
Kiel, Douglas P.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Evidence suggests that both green tea polyphenols (GTP) and Tai Chi (TC) exercise may benefit bone health in osteopenic women. However, their safety in this population has never been systematically investigated. In particular, there have been hepatotoxicity concerns related to green tea extract. This study was to evaluate the safety of 24 weeks of GTP supplementation combined with TC exercise in postmenopausal osteopenic women, along with effects on quality of life in this population.

Author(s): 
Shen, Chwan-Li
Chyu, Ming-Chien
Pence, Barbara C.
Yeh, James K.
Zhang, Yan
Felton, Carol K.
Doctolero, Susan
Wang, Jia-Sheng
Publication Title: 
Journal of Hepatology

BACKGROUND & AIMS: To evaluate the prevalence and risk factors for low bone mineral density (BMD) in persons co-infected with HIV and Hepatitis C. METHODS: HIV/HCV co-infected study participants (n=179) were recruited into a prospective cohort and underwent dual-energy X-ray absorptiometry (DXA) within 1 year of a liver biopsy. Fibrosis staging was evaluated according to the METAVIR system. Osteoporosis was defined as a T-score ≤-2.5.

Author(s): 
El-Maouche, Diala
Mehta, Shruti H.
Sutcliffe, Catherine
Higgins, Yvonne
Torbenson, Michael S.
Moore, Richard D.
Thomas, David L.
Sulkowski, Mark S.
Brown, Todd T.
Publication Title: 
Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

Postmenopausal women with osteopenia received green tea polyphenols (GTP) supplement and/or Tai Chi exercise for 6 months. Bone turnover biomarkers, calcium metabolism, and muscle strength were measured. This study showed that GTP supplementation and Tai Chi exercise increased bone formation biomarkers and improved bone turnover rate. Tai Chi exercise increased serum parathyroid hormone. GTP supplementation, Tai Chi exercise, and the combination of the two all improved muscle strength in postmenopausal women with osteopenia.

Author(s): 
Shen, C.-L.
Chyu, M.-C.
Yeh, J. K.
Zhang, Y.
Pence, B. C.
Felton, C. K.
Brismée, J.-M.
Arjmandi, B. H.
Doctolero, S.
Wang, J.-S.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Tai Chi (TC) is a mind-body exercise that shows potential as an effective and safe intervention for preventing fall-related fractures in the elderly. Few randomized trials have simultaneously evaluated TC's potential to reduce bone loss and improve fall-predictive balance parameters in osteopenic women. METHODS: In a pragmatic randomized trial, 86 post-menopausal osteopenic women, aged 45-70, were recruited from community clinics. Women were assigned to either nine months of TC training plus usual care (UC) vs. UC alone.

Author(s): 
Wayne, Peter M.
Kiel, Douglas P.
Buring, Julie E.
Connors, Ellen M.
Bonato, Paolo
Yeh, Gloria Y.
Cohen, Calvin J.
Mancinelli, Chiara
Davis, Roger B.

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