Bone Marrow Cells

Publication Title: 
Endokrynologia Polska

Studies in mutant, gene knock-out and transgenic mice have demonstrated that growth hormone (GH) signalling has a major impact on ageing and longevity. Growth hormone-resistant and GH-deficient animals live much longer than their normal siblings, while transgenic mice overexpressing GH are short lived. Actions of GH in juvenile animals appear to be particularly important for life extension and responsible for various phenotypic characteristics of long-lived hypopituitary mutants.

Author(s): 
Bartke, Andrzej
Westbrook, Reyhan
Sun, Liou
Ratajczak, Mariusz
Publication Title: 
Transplantation

Alloantibody can be a major barrier to successful organ transplantation; however, therapy to control antibody production or to alter its impact on the allograft remains limited. The goal of this review is to examine the regulatory steps that are involved in the generation of alloreactive B cells, with a specific emphasis on how known mechanisms relate to clinical situations in transplant recipients. Thus, we will examine the process of activation of mature, naÔve B cells and how this relates to de novo antibody production.

Author(s): 
Stegall, Mark D.
Moore, Natalie
Taner, Timucin
Li, Han
Dean, Patrick G.
Publication Title: 
Methods in Molecular Biology (Clifton, N.J.)

Regulatory T cells (Tregs) are amongst the most widely studied cells in a variety of immune-mediated conditions, including transplantation and Graft Versus Host Disease (GVHD), cancer and autoimmunity; indeed, there is great interest in the tolerogenic potential of Treg-based therapy. Consequently, the need to establish the mechanisms that determine Treg survival and longevity, in addition to developing new tools to monitor these parameters, is paramount.

Author(s): 
Lewandrowski, Grant K.
Magee, Ciara N.
Mounayar, Marwan
Tannous, Bakhos A.
Azzi, Jamil
Publication Title: 
Terapevticheski? Arkhiv
Author(s): 
Mazharov, M. K.
Publication Title: 
Endokrynologia Polska

Studies in mutant, gene knock-out and transgenic mice have demonstrated that growth hormone (GH) signalling has a major impact on ageing and longevity. Growth hormone-resistant and GH-deficient animals live much longer than their normal siblings, while transgenic mice overexpressing GH are short lived. Actions of GH in juvenile animals appear to be particularly important for life extension and responsible for various phenotypic characteristics of long-lived hypopituitary mutants.

Author(s): 
Bartke, Andrzej
Westbrook, Reyhan
Sun, Liou
Ratajczak, Mariusz
Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

Artesunate is a derivate of artemisinin that is both an antimalarial agent and acts cytotoxically on tumor cells. Despite its therapeutic use, its in vivo genotoxic potential has still not been evaluated. This study, therefore, was an investigation into the effects of a single oral administration of artesunate with an in vivo comet assay that analyzed leukocytes from peripheral blood and liver cells, and a micronucleus (MN) assay of bone marrow cells from male Swiss mice. The artesunate was administered by oral gavage at doses of 5, 50 and 100 mg/kg.

Author(s): 
Aquino, Ivani
Perazzo, Fábio Ferreira
Maistro, Edson Luis
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Ayurveda, the traditional Indian system of medicine has given great emphasis to the promotion of health. Rasayana is one of the eight branches of Ayurveda which refers to rejuvenant therapy. It has been reported that rasayanas have immuno-modulatory, antioxidant and antitumor functions, however, the genotoxic potential and modulation of DNA repair of many rasayanas have not been evaluated.

Author(s): 
Guruprasad, Kanive Parashiva
Subramanian, Advait
Singh, Vikram Jeet
Sharma, Raghavendra Sudheer Kumar
Gopinath, Puthiya Mundyat
Sewram, Vikash
Varier, Panniyampilly Madhavankutty
Satyamoorthy, Kapaettu
Publication Title: 
Indian Journal of Experimental Biology

Single injection of phenylhydrazine[PH] reduced the number of RBC and haemoglobin content; decreased myeloid; erythroid cell ratio in bone marrow and increased Cathepsin D activity in spleen of rats. Ayurvedic drugs raktavardhak, punarnavasav and navayas louh recovered the number of RBC and haemoglobin content and raised myeloid: erythroid cell ratio and normalised cathepsin D activities by counteracting the action phenyl hydrazine.

Author(s): 
Patil, S.
Kanase, A.
Kulkarni, P. H.
Publication Title: 
Fitoterapia

The present study investigates the effect of in vivo administration of alcoholic extract of Tinospora cordifolia whole plant (ALTC) on the proliferation and myeloid differentiation of bone marrow hematopoietic precursor cells in mice bearing a transplantable T cell lymphoma of spontaneous origin designated as Dalton's lymphoma (DL). BMC obtained from ALTC administered DL-bearing mice showed an enhanced BMC proliferation and colony forming ability in vitro in response to L929 conditioned medium as a source of colony stimulating factor (CSF).

Author(s): 
Singh, Sukh Mahendra
Singh, Nisha
Shrivastava, Pratima
Publication Title: 
Immunopharmacology and Immunotoxicology

Cancer is responsible for millions of deaths each year worldwide. Pharmacological intervention with plant-derived products alone or in combination to reverse, suppress, or prevent the cancer progression plays a key role in the fight against this terrible disease. Aerva lanata is an important medicinal plant widely used in traditional systems of medicine like ayurveda and siddha. Ethanolic extract of whole plant of A. lanata exhibited immunomodulatory and antitumor activity.

Author(s): 
Siveen, K. S.
Kuttan, Girija

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