Bone Morphogenetic Protein 2

Publication Title: 
The American Journal of Clinical Nutrition

Bone mass declines progressively with age in both men and women from the age of approximately 30 y. Increased longevity will inevitability be associated with an increase in the incidence of osteoporosis, its associated complications, and incurred health care costs. Current pharmacologic approaches focus on inhibiting bone resorption in those with osteoporosis but do little to improve bone mass. Increased understanding of the cellular events responsible for normal bone formation has led to multiple pathways that can be targeted to positively influence bone mass.

Author(s): 
Mundy, Gregory R.
Publication Title: 
The Journal of Biological Chemistry

Bone morphogenetic proteins (BMPs) belong to the TGF-beta superfamily and play an important role in development and in many cellular processes. We have found that BMP-2, BMP-6, and BMP-9 induce the most potent osteogenic differentiation of mesenchymal stem cells. Expression profiling analysis has revealed that the Inhibitors of DNA binding/differentiation (Id)-1, Id-2, and Id-3 are among the most significantly up-regulated genes upon BMP-2, BMP-6, or BMP-9 stimulation. Here, we sought to determine the functional role of these Id proteins in BMP-induced osteoblast differentiation.

Author(s): 
Peng, Ying
Kang, Quan
Luo, Qing
Jiang, Wei
Si, Weike
Liu, Bernard A.
Luu, Hue H.
Park, Jong Kyung
Li, Xinmin
Luo, Jeffrey
Montag, Anthony G.
Haydon, Rex C.
He, Tong-Chuan
Publication Title: 
Journal of Biomechanics

Bone cells and their precursors are sensitive to changes in their biomechanical environment. The importance of mechanical stimuli has been observed in bone homeostasis and osteogenesis, but the mechanisms responsible for osteogenic induction in response to mechanical signals are poorly understood. We hypothesized that compressive forces could exert an osteogenic effect on osteoblasts and act in a dose-dependent manner. To test our hypothesis, electrospun poly(epsilon-caprolactone) (PCL) scaffolds were used as a 3-D microenvironment for osteoblast culture.

Author(s): 
Rath, Bjoern
Nam, Jin
Knobloch, Thomas J.
Lannutti, John J.
Agarwal, Sudha
Publication Title: 
Chinese Medical Journal

BACKGROUND: Icariine is a flavonoid isolated from a traditional Chinese medicine Epimedium pubescens and is the main active compound of it. Recently, Epimedium pubescens was found to have a therapeutic effect on osteoporosis. But the mechanism is unclear. The aim of the study was to research the effect of Icariine on the proliferation and differentiation of human osteoblasts. METHODS: Human osteoblasts were obtained by inducing human marrow mesenchymal stem cells (hMSCs) directionally and were cultured in the presence of various concentrations of Icariine.

Author(s): 
Yin, Xiao-xue
Chen, Zhong-qiang
Liu, Zhong-jun
Ma, Qing-Jun
Dang, Geng-ting
Publication Title: 
Sheng Li Xue Bao: [Acta Physiologica Sinica]

Tetramethylpyrazine (TMP), an effective component of traditional Chinese medicine Chuanxiong, is commonly used to resolve embolism. Its possible therapeutic effect against atherosclerosis has received considerable attention recently. Angiotensin II (Ang II) is highly implicated in the proliferation of vascular smooth muscle cells (VSMCs), resulting in atherosclerosis. The mechanisms of TMP in the proliferation of VSMCs induced by Ang II remain to be defined.

Author(s): 
Ren, Xin-Yu
Ruan, Qiu-Rong
Zhu, Da-He
Zhu, Min
Qu, Zhi-Ling
Lu, Jun
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Si-Wu-Tang (SWT), a Traditional Chinese Medicine (TCM) formula, is widely used for the treatment of gynopathies diseases such as menstrual discomfort, climacteric syndrome, dysmenorrhea, and other estrogen-related diseases. Recent studies have shown that SWT can treat primary dysmenorrhea, have anti-pruritic anti-inflammatory effects, and protect against radiation-induced bone marrow damage in an animal model.

Author(s): 
Wu, Chi-Ming
Chen, Po-Chun
Li, Te-Mao
Fong, Yi-Chin
Tang, Chih-Hsin
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