Bone Regeneration

Publication Title: 
Cryobiology
Author(s): 
Thomford, N. R.
Wilson, W. H.
Blackburn, E. D.
Pace, W. G.
Publication Title: 
Cell Death & Disease

Withania somnifera or Ashwagandha is a medicinal herb of Ayurveda. Though the extract and purified molecules, withanolides, from this plant have been shown to have different pharmacological activities, their effect on bone formation has not been studied. Here, we show that one of the withanolide, withaferin A (WFA) acts as a proteasomal inhibitor (PI) and binds to specific catalytic β subunit of the 20S proteasome. It exerts positive effect on osteoblast by increasing osteoblast proliferation and differentiation.

Author(s): 
Khedgikar, V.
Kushwaha, P.
Gautam, J.
Verma, A.
Changkija, B.
Kumar, A.
Sharma, S.
Nagar, G. K.
Singh, D.
Trivedi, P. K.
Sangwan, N. S.
Mishra, P. R.
Trivedi, R.
Publication Title: 
Cell Death & Disease

Withania somnifera or Ashwagandha is a medicinal herb of Ayurveda. Though the extract and purified molecules, withanolides, from this plant have been shown to have different pharmacological activities, their effect on bone formation has not been studied. Here, we show that one of the withanolide, withaferin A (WFA) acts as a proteasomal inhibitor (PI) and binds to specific catalytic β subunit of the 20S proteasome. It exerts positive effect on osteoblast by increasing osteoblast proliferation and differentiation.

Author(s): 
Khedgikar, V.
Kushwaha, P.
Gautam, J.
Verma, A.
Changkija, B.
Kumar, A.
Sharma, S.
Nagar, G. K.
Singh, D.
Trivedi, P. K.
Sangwan, N. S.
Mishra, P. R.
Trivedi, R.
Publication Title: 
International Journal of Oral and Maxillofacial Surgery

Recent reports on orthopaedic surgery focus on mechanical stimulation of the regenerate during distraction therapy of non-unions in long-bone-surgery. In the field of maxillofacial surgery, callus stimulating techniques are rarely reported. The case of a 65-year-old man with a radiogenic mandibular non-union after ablative tumour therapy and pre-operative radiation therapy presented with a non-union. Vertical distraction in combination with subsequent repeated, stepwise compression and distraction (=massage) had a positive effect on the consolidation of the regenerate.

Author(s): 
Lazar, F. C.
Klesper, B.
Carls, P.
Siessegger, M.
Hidding, J.
Zoeller, J.
Subscribe to RSS - Bone Regeneration