Bone Resorption

Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The fruit of the Terminalia chebula tree has been widely used for the treatment of various disorders. Its anti-diabetic, anti-mutagenic, anti-oxidant, anti-bacterial, anti-fungal, and anti-viral effects have been studied. Dental plaque bacteria (DPB) are intimately associated with gingivitis and periodontitis. In the quest for materials that will prove useful in the treatment and prevention of periodontal disease, we investigated the preventive effects of an ethanol extract of Terminalia chebula (EETC) on DPB-induced inflammation and bone resorption.

Author(s): 
Lee, Jongsung
Nho, Youn Hwa
Yun, Seok Kyun
Hwang, Young Sun
Publication Title: 
PloS One

Bioactive bone substitute materials are a valuable alternative to autologous bone transplantations in the repair of skeletal defects. However, clinical studies have reported varying success rates for many commonly used biomaterials. While osteoblasts have traditionally been regarded as key players mediating osseointegration, increasing evidence suggests that bone-resorbing osteoclasts are of crucial importance for the longevity of applied biomaterials.

Author(s): 
Keller, Johannes
Brink, Silja
Busse, Bjˆrn
Schilling, Arndt F.
Schinke, Thorsten
Amling, Michael
Lange, Tobias
Publication Title: 
Experimental Gerontology

Skeletal remodelling is a continuous process during life and is still active also in extreme senescence. In the elderly, bone resorption often prevails over bone formation, causing bone loss and fragility. Elderly subjects are exposed to the risk of fractures, and loss of self-sufficiency, if considering that the proximal femur is the most frequently involved site. Bone remodelling can maintain circulating calcium within physiological ranges, at the expense of a substantial loss of this ion from the skeleton, particularly during senescence.

Author(s): 
Passeri, Giovanni
Vescovini, Rosanna
Sansoni, Paolo
Galli, Carlo
Franceschi, Claudio
Passeri, Mario
Italian Multicentric Study on Centenarians (IMUSCE)
Publication Title: 
Molecular Cancer Therapeutics

Bone loss is one of the major complications of advanced cancers such as breast cancer, prostate cancer, and multiple myeloma; agents that can suppress this bone loss have therapeutic potential. Extensive research within the last decade has revealed that RANKL, a member of the tumor necrosis factor superfamily, plays a major role in cancer-associated bone resorption and thus is a therapeutic target.

Author(s): 
Sung, Bokyung
Oyajobi, Babatunde
Aggarwal, Bharat B.
Publication Title: 
Phytotherapy research: PTR

Bone metabolism involves a complex balance between the deposition of matrix and mineralization and resorption. There is now good evidence that dietary components and herbal products can influence these processes, particularly by inhibiting bone resorption, thus having beneficial effects on the skeleton. For example, it has been reported that a number of common vegetables, including onion, garlic and parsley, can inhibit bone resorption in ovariectomized rats.

Author(s): 
Putnam, Sophie E.
Scutt, Andy M.
Bicknell, Katrina
Priestley, Caroline M.
Williamson, Elizabeth M.
Publication Title: 
Molecular Cancer Therapeutics

Bone loss is one of the major complications of advanced cancers such as breast cancer, prostate cancer, and multiple myeloma; agents that can suppress this bone loss have therapeutic potential. Extensive research within the last decade has revealed that RANKL, a member of the tumor necrosis factor superfamily, plays a major role in cancer-associated bone resorption and thus is a therapeutic target.

Author(s): 
Sung, Bokyung
Oyajobi, Babatunde
Aggarwal, Bharat B.
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

INTRODUCTION: The purpose of this 3-way crossover study was to identify the effective dose of soy protein isolate enriched with isoflavones for suppressing bone resorption in postmenopausal women using a novel, rapid assessment of antibone resorbing treatments. METHODS: Thirteen postmenopausal women (>or=6 yr since menopause) were predosed with 41Ca iv. After a 200-d baseline period, subjects were given 43 g soy protein/d that contained 0, 97.5, or 135.5 mg total isoflavones in randomized order. The soy protein isolate powder was incorporated into baked products and beverages.

Author(s): 
Cheong, J. M. K.
Martin, B. R.
Jackson, G. S.
Elmore, D.
McCabe, G. P.
Nolan, J. R.
Barnes, S.
Peacock, M.
Weaver, C. M.
Publication Title: 
The American Journal of Clinical Nutrition

The Purdue-University of Alabama Botanicals Research Center for Age Related Disease joins novel technologies to study the bioavailability of bioactive polyphenolic constituents and their relation to health. Many diseases that manifest with age relate to oxidative stress and tissue damage. Our goal is to follow the fate of bioactive constituents from a complex mixture to the organ affected by the disease and relate that to a protective mechanism. Equally important is to screen commercially available botanicals for their efficacy and safety.

Author(s): 
Weaver, Connie M.
Barnes, Stephen
Wyss, J. Michael
Kim, Helen
Morré, Dorothy M.
Morré, D. James
Simon, James E.
Lila, Mary Ann
Janle, Elsa M.
Ferruzzi, Mario G.
Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

INTRODUCTION: Reduction of ovarian estrogen secretion at menopause increases net bone resorption and leads to bone loss. Isoflavones have been reported to protect bone from estrogen deficiency, but their modest effects on bone resorption have been difficult to measure with traditional analytical methods.

Author(s): 
Weaver, C. M.
Martin, B. R.
Jackson, G. S.
McCabe, G. P.
Nolan, J. R.
McCabe, L. D.
Barnes, S.
Reinwald, S.
Boris, M. E.
Peacock, M.
Publication Title: 
The Journal of Nutrition

(3)H-tetracycline ((3)H-TC) is thought to be superior to calcium (Ca) isotopic tracers for estimating bone resorption rates due to the less redeposition upon release in animal models. However, these 2 tracers have not been compared directly using complete kinetic studies with sampling of blood, urine, feces, and bone. Our goal was to compare the 2 isotopes for evaluating bone turnover. We firstly developed a model for (3)H-TC kinetics in 4-mo-old female rats (n = 3) by measuring the tracer in serum, urine, and feces over 4 d.

Author(s): 
Zhao, Yongdong
Cheong, Jennifer M. K.
Lee, WangHee
Wastney, Meryl
Martin, Berdine R.
Weaver, Connie M.

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