Boronic Acids

Publication Title: 
Neurotoxicology

Boron-containing compounds (BCCs), particularly boron containing acids (BCAs), have become attractive moieties or molecules in drug development. It has been suggested that when functional groups with boron atoms are added to well-known drugs, the latter are conferred with greater potency and efficacy in relation to their target receptors. However, the use of BCAs in drug development is limited due to the lack of a toxicological profile. Consequently, the aim of the present study was to evaluate the acute toxicity of boric and boronic acids.

Author(s): 
Soriano-Ursúa, Marvin A.
Farfán-García, Eunice D.
López-Cabrera, Yessica
Querejeta, Enrique
Trujillo-Ferrara, José G.
Publication Title: 
Blood

Most anticancer chemotherapies are immunosuppressive and induce nonimmunogenic tumor cell death. Bortezomib, a specific inhibitor of 26S proteasome, has shown clinical activity in several human tumors, including myeloma. Here we show that the uptake of human myeloma cells by dendritic cells (DCs) after tumor cell death by bortezomib, but not gamma irradiation or steroids, leads to the induction of antitumor immunity, including against primary tumor cells, without the need for any additional adjuvants.

Author(s): 
Spisek, Radek
Charalambous, Anna
Mazumder, Amitabha
Vesole, David H.
Jagannath, Sundar
Dhodapkar, Madhav V.
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Helicobacter pylori infection of the stomach causes peptic ulcer disease and gastric cancer. Despite eliciting a vigorous immune response, the bacterium persists for the life of the host. An important antimicrobial mechanism is the production of NO derived from inducible NO synthase (iNOS). We have reported that macrophages can kill H. pylori in vitro by an NO-dependent mechanism, but supraphysiologic levels of the iNOS substrate l-arginine are required. Because H.

Author(s): 
Lewis, Nuruddeen D.
Asim, Mohammad
Barry, Daniel P.
Singh, Kshipra
de Sablet, Thibaut
Boucher, Jean-Luc
Gobert, Alain P.
Chaturvedi, Rupesh
Wilson, Keith T.
Publication Title: 
Journal of Hematology & Oncology

BACKGROUND: This single-arm study evaluated feasibility, safety, and initial efficacy of electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy (PN) in cancer patients with multiple myeloma. METHODS: Patients with neuropathy ≥ grade 2 received 20 acupuncture treatments over 9 weeks. RESULTS: For the 19 evaluable patients, Functional Assessment of Cancer Therapy/Gynecological Oncology Group-Neurotoxicity (FACT/GOG/NTX) mean (SD) scores improved significantly between baseline and week 13 (20.8 [9.6] vs 13.2 [8.5], p = 0.0002).

Author(s): 
Garcia, M. Kay
Cohen, Lorenzo
Guo, Ying
Zhou, Yuhong
You, Bing
Chiang, Joseph
Orlowski, Robert Z.
Weber, Donna
Shah, Jatin
Alexanian, Raymond
Thomas, Sheeba
Romaguera, Jorge
Zhang, Liang
Badillo, Maria
Chen, Yiming
Wei, Qi
Lee, Richard
Delasalle, Kay
Green, Vivian
Wang, Michael
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