Boswellia

Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Medicinal plant products are used orally for treating osteoarthritis. Although their mechanisms of action have not yet been elucidated in full detail, interactions with common inflammatory mediators provide a rationale for using them to treat osteoarthritic complaints. OBJECTIVES: To update a previous Cochrane review to assess the benefits and harms of oral medicinal plant products in treating osteoarthritis.

Author(s): 
Cameron, Melainie
Chrubasik, Sigrun
Publication Title: 
Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre

The gastrointestinal tract digests and absorbs dietary nutrients, protects the body against physical and chemical damage from contents in its lumen, provides immunity against external antigens, and keeps an optimum environment for the gut microbiota. These functions cannot be performed normally in several diseases of which the following are discussed here: irritable bowel syndrome and inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis.

Author(s): 
Khan, Islam
Samson, Sue E.
Grover, Ashok Kumar
Publication Title: 
Phytochemistry

Frankincense has been known, traded and used throughout the ages for its exceptional aroma properties, and is still commonly used in both secular and religious settings to convey a pleasant odor. Surprisingly, the odoriferous principle(s) underlying its unique odor profile have never been published. In this study, resin samples of Boswellia sacra Flueck. from both Somalia and Oman were investigated by aroma extract dilution analysis.

Author(s): 
Niebler, Johannes
Buettner, Andrea
Publication Title: 
British Journal of Pharmacology

Clinical studies suggest that the Ayurvedic plant Boswellia serrata may be effective in reducing diarrhoea in patients with inflammatory bowel disease. In the present study, we evaluated the effect of a Boswellia serrata gum resin extract (BSE) on intestinal motility and diarrhoea in rodents. BSE depressed electrically-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum, being more potent in inhibiting the contractions induced by acetylcholine and barium chloride.

Author(s): 
Borrelli, Francesca
Capasso, Francesco
Capasso, Raffaele
Ascione, Valeria
Aviello, Gabriella
Longo, Rocco
Izzo, Angelo A.
Publication Title: 
International Journal of Cancer. Journal International Du Cancer

Numerous cancer therapeutics were originally identified from natural products used in traditional medicine. One such agent is acetyl-11-keto-beta-boswellic acid (AKBA), derived from the gum resin of the Boswellia serrata known as Salai guggal or Indian frankincense. Traditionally, it has been used in Ayurvedic medicine to treat proinflammatory conditions. In this report, we hypothesized that AKBA can affect the growth and metastasis of colorectal cancer (CRC) in orthotopically implanted tumors in nude mice.

Author(s): 
Yadav, Vivek R.
Prasad, Sahdeo
Sung, Bokyung
Gelovani, Juri G.
Guha, Sushovan
Krishnan, Sunil
Aggarwal, Bharat B.
Publication Title: 
FEBS letters

Structural integrity of microtubule protein (MTP) is pivotal for its physiological roles. Disruption of the MTP network is known to be involved in neurodegenerative disorders. The gum resin of plants of the boswellia species, with β-boswellic acid (BBA) as the major component, has long been used in Ayurveda and Oriental Medicine to prevent amnesia. In the current study, we addressed the question whether BBA affects assembly dynamics behavior of tubulin.

Author(s): 
Karima, Oveis
Riazi, Gholamhossein
Khodadadi, Sirus
Yousefi, Reza
Mahnam, Karim
Mokhtari, Farzad
Cheraghi, Tayebe
Hoveizi, Elham
Moosavi-Movahedi, Ali Akbar
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Regardless of the availability of therapeutic options, the overall 5-year survival for patients diagnosed with pancreatic cancer remains less than 5%. Gum resins from Boswellia species, also known as frankincense, have been used as a major ingredient in Ayurvedic and Chinese medicine to treat a variety of health-related conditions. Both frankincense chemical extracts and essential oil prepared from Boswellia species gum resins exhibit anti-neoplastic activity, and have been investigated as potential anti-cancer agents.

Author(s): 
Ni, Xiao
Suhail, Mahmoud M.
Yang, Qing
Cao, Amy
Fung, Kar-Ming
Postier, Russell G.
Woolley, Cole
Young, Gary
Zhang, Jingzhe
Lin, Hsueh-Kung
Publication Title: 
Wiener Medizinische Wochenschrift (1946)

Preparations from the gum resin of Boswellia serrata have been used as a traditional remedy in Ayurvedic medicine in India for the treatment of inflammatory diseases. Compounds from the gum with genuine antiinflammatory effects are pentacyclic triterpenes of the boswellic acid type. Boswellic acids inhibit the leukotriene biosynthesis in neutrophilic granulocytes by a non-redox, noncompetitive inhibition of 5-lipoxygenase. The effect is triggered by boswellic acids binding to the enzyme.

Author(s): 
Ammon, H. P. T.
Publication Title: 
Indian Journal of Experimental Biology

Boswellia serrata, Linn F (Burseraceae) is commonly used in Indian system of medicine (Ayurvedic) as an anti-inflammatory, analgesic, anti-arthritic and anti-proliferative agent. This study was planned to investigate the water-soluble fraction of the oleoresin gum of Boswellia serrata (BS extract) on lipopolysaccharide (LPS) induced nitric oxide (NO) production by macrophages under in vivo and in vitro conditions. In the previous condition, rats were fed on atherogenic diet (2.5% cholesterol, 1% cholic acid, 15.7 % saturated fat) along with the BS extract for 90 days.

Author(s): 
Pandey, Ravi S.
Singh, Birendra K.
Tripathi, Yamini B.
Publication Title: 
British Journal of Pharmacology

Clinical studies suggest that the Ayurvedic plant Boswellia serrata may be effective in reducing diarrhoea in patients with inflammatory bowel disease. In the present study, we evaluated the effect of a Boswellia serrata gum resin extract (BSE) on intestinal motility and diarrhoea in rodents. BSE depressed electrically-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum, being more potent in inhibiting the contractions induced by acetylcholine and barium chloride.

Author(s): 
Borrelli, Francesca
Capasso, Francesco
Capasso, Raffaele
Ascione, Valeria
Aviello, Gabriella
Longo, Rocco
Izzo, Angelo A.

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