Breast Neoplasms

Publication Title: 
International Journal of Radiation Oncology, Biology, Physics

PURPOSE: To investigate the incidence of and variables associated with clinically evident fat necrosis in women treated on a protocol of high-dose-rate (HDR) brachytherapy alone without external-beam whole-breast irradiation for early-stage breast carcinoma. METHODS AND MATERIALS: From 6/1997 until 8/1999, 30 women diagnosed with Stage I or II breast carcinoma underwent surgical excision and postoperative irradiation via HDR brachytherapy implant as part of a multi-institutional clinical Phase I/II protocol.

Author(s): 
Wazer, D. E.
Lowther, D.
Boyle, T.
Ulin, K.
Neuschatz, A.
Ruthazer, R.
DiPetrillo, T. A.
Publication Title: 
International Journal of Radiation Oncology, Biology, Physics

PURPOSE: To investigate the feasibility, toxicity, cosmetic outcome, and local control of high-dose-rate (HDR) brachytherapy alone without whole breast external beam irradiation for early-stage breast carcinoma. METHODS AND MATERIALS: Between June 1997 and August 1999, 32 women diagnosed with a total of 33 AJCC Stage I/II breast carcinomas underwent surgical breast excision and postoperative irradiation using HDR brachytherapy interstitial implantation as part of a multi-institutional clinical Phase I/II protocol.

Author(s): 
Wazer, David E.
Berle, Lisa
Graham, Roger
Chung, Maureen
Rothschild, Janice
Graves, Theresa
Cady, Blake
Ulin, Kenneth
Ruthazer, Robin
DiPetrillo, Thomas A.
Publication Title: 
Cancer Research

The vast majority of breast cancers are carcinomas that arise from mammary epithelial cells (MECs). One of the key early events in tumorigenic transformation is the ability of cells to overcome replicative senescence. However, the precise genetic changes that are responsible for this event in MECs is largely unknown. Here, we report that Bmi-1, originally identified as a c-Myc cooperating oncoprotein, can bypass senescence, extend the replicative life span, and immortalize MECs. Furthermore, Bmi-1 was overexpressed in immortal MECs and several breast cancer cell lines.

Author(s): 
Dimri, Goberdhan P.
Martinez, Jose-Luis
Jacobs, Jacqueline J. L.
Keblusek, Petra
Itahana, Koji
Van Lohuizen, Maarten
Campisi, Judith
Wazer, David E.
Band, Vimla
Publication Title: 
Voprosy Onkologii

There is a considerable variation in individual lifespan among cancer patients with identical diagnosis. We used damped exponential approximation, which includes both single- and double-compartment extension, for radiobiological assessment of survival curves among cases of breast, lung and oro-pharyngeal cancer. It was shown that in certain cases (breast--T2N1-2M0T3N1-2M0 and oro-pharyngeal cancer--T2-4N1-3M0) the curves can be identified with the two compartments which in turn are associated with different rates of mortality.

Author(s): 
Bochkareva, T. N.
Ekimova, L. P.
Nemkova, E. V.
Sokurenko, V. P.
Shutko, A. N.
Publication Title: 
Oncology Reports

Silent information regulator 2 (SIR2) is a highly conserved protein, the mammalian orthologue of which, SIRT1, exhibits histone deacetylase activity. SIRT1 is involved not in only longevity due to caloric restriction but in a variety of diseases such as diabetes, cardiovascular dysfunction and neurodegeneration. However, accumulating evidence shows that SIRT1 is overexpressed in various types of malignant cells, and its inhibitors suppress the growth of tumor cells. The relationship between SIRT1 and metastasis remains to be clarified.

Author(s): 
Suzuki, Kensuke
Hayashi, Ryuji
Ichikawa, Tomomi
Imanishi, Shingo
Yamada, Toru
Inomata, Minehiko
Miwa, Toshiro
Matsui, Shoko
Usui, Isao
Urakaze, Masaharu
Matsuya, Yuji
Ogawa, Hirofumi
Sakurai, Hiroaki
Saiki, Ikuo
Tobe, Kazuyuki
Publication Title: 
Oncogene

Mitochondrial dysfunction has been a hallmark of cancer. However, whether it has a causative role awaits to be elucidated. Here, using an animal model derived from inactivation of SUV3, a mitochondrial helicase, we demonstrated that mSuv3+/- mice harbored increased mitochondrial DNA (mtDNA) mutations and decreased mtDNA copy numbers, leading to tumor development in various sites and shortened lifespan. These phenotypes were transmitted maternally, indicating the etiological role of the mitochondria.

Author(s): 
Chen, P.-L.
Chen, C.-F.
Chen, Y.
Guo, X. E.
Huang, C.-K.
Shew, J.-Y.
Reddick, R. L.
Wallace, D. C.
Lee, W.-H.
Publication Title: 
Basic & Clinical Pharmacology & Toxicology

Transient receptor potential melastatin 7 (TRPM7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively.

Author(s): 
Kim, Byung J.
Nam, Joo H.
Kwon, Young K.
So, Insuk
Kim, Seon J.
Publication Title: 
BMC cancer

BACKGROUND: Cancer is a significant and growing problem worldwide. While this increase may, in part, be attributed to increasing longevity, improved case notifications and risk-enhancing lifestyle (such as smoking, diet and obesity), hygiene-related factors resulting in immuno-regulatory failure may also play a major role and call for a revision of vaccination strategies to protect against a range of cancers in addition to infections. DISCUSSION: Human endogenous retroviruses (HERVs) are a significant component of a wider family of retroelements that constitutes part of the human genome.

Author(s): 
Cegolon, Luca
Salata, Cristiano
Weiderpass, Elisabete
Vineis, Paolo
Pal˘, Giorgio
Mastrangelo, Giuseppe
Publication Title: 
Cancer Treatment and Research
Author(s): 
Cobleigh, M. A.
Publication Title: 
Urology

Breast and prostate cancer share similar intrinsic and extrinsic risk factors. Based on laboratory, ecologic/international comparison, and case-control studies, the impact of dietary fat or other fat subtypes has been suggested as a potential route to reduce risk. Recent large-scale prospective studies have failed to find an association between fat and breast cancer risk. These studies may provide some insight for researchers examining the relation between fat and prostate cancer.

Author(s): 
Moyad, Mark A.

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