Bretylium Compounds

Publication Title: 
Pacing and clinical electrophysiology: PACE

BACKGROUND: Patients with ischemic heart disease may require antianginal and/or antiarrhythmic regimes. These patients may also be candidates for implantable defibrillators. The effects of antiarrhythmics, such as bretylium, or calcium antagonists, such as verapamil, nifedipine, or diltiazem on internal defibrillation efficacy have been inconsistent or are unknown. METHODS AND RESULTS: The effects of bretylium and verapamil on the energy requirements for ventricular defibrillation threshold (DFT) were determined in 92 open-chest anesthetized pigs.

Author(s): 
Jones, D. L.
Kim, Y. H.
Natale, A.
Klein, G. J.
Varin, F.
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