Bronchial Hyperreactivity

Publication Title: 
Sports Medicine (Auckland, N.Z.)

BACKGROUND: Although physical exercise is recommended for asthmatics, evidence on the effects of exercise on clinical key factors is still missing. OBJECTIVES: We performed a systematic review and meta-analysis to determine the effect of exercise training (EXT) on quality of life (QoL), bronchial hyperresponsiveness (BHR), exercise-induced bronchoconstriction (EIB), lung function and exercise capacity, plus the factors affecting changes in QoL and exercise capacity in asthmatics after a period of EXT.

Author(s): 
Eichenberger, Philipp A.
Diener, Stephanie N.
Kofmehl, Reto
Spengler, Christina M.
Publication Title: 
Schweizerische Medizinische Wochenschrift. Supplementum

In recent years our knowledge of the immune system and the pathogenesis of immune disorders has increased. There has been much research on the complex connections between the psyche, the central nervous system and the immune system and the effect of mood on disease processes. This paper reviews the evidence on the effects of hypnosis on the allergic skin test reaction, on allergies, particularly respiratory allergies and hayfever, and on bronchial hyperreactivity and asthma.

Author(s): 
Wyler-Harper, J.
Bircher, A. J.
Langewitz, W.
Kiss, A.
Publication Title: 
Nihon Ky?bu Shikkan Gakkai Zasshi

In the present study, patients with asthma ware evaluated in order to find out if the emotional stress itself causes their asthmatic attack or not, and to elucidate the mechanisms underlining it. 41.8% of the 55 patients demonstrated asthmatic attack during hypnosis evaluated their symptoms and significant decrease in their air flow. The non-responders showed significant increase ind the serum DBH level (p < 0.05) during the hypnosis compared with their baseline value, while the responders did not show any significant change in the serum concentration.

Author(s): 
Inoue, H.
Kobayashi, H.
Chiba, T.
Publication Title: 
Sports Medicine (Auckland, N.Z.)

BACKGROUND: Although physical exercise is recommended for asthmatics, evidence on the effects of exercise on clinical key factors is still missing. OBJECTIVES: We performed a systematic review and meta-analysis to determine the effect of exercise training (EXT) on quality of life (QoL), bronchial hyperresponsiveness (BHR), exercise-induced bronchoconstriction (EIB), lung function and exercise capacity, plus the factors affecting changes in QoL and exercise capacity in asthmatics after a period of EXT.

Author(s): 
Eichenberger, Philipp A.
Diener, Stephanie N.
Kofmehl, Reto
Spengler, Christina M.
Publication Title: 
Cellular Immunology

OBJECTIVE: Bromelain, a clinically used pineapple extract and natural product, has reported anti-inflammatory and immunomodulatory activities. The purpose of this study was to determine the effect of bromelain treatment in an ovalbumin (OVA)-induced murine model of allergic airway disease (AAD). METHODS: To establish AAD, mice were sensitized with intraperitoneal (i.p.) OVA/alum and challenged with daily OVA aerosols. Mice were treated i.p. with either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days.

Author(s): 
Secor, Eric R.
Carson, William F.
Cloutier, Michelle M.
Guernsey, Linda A.
Schramm, Craig M.
Wu, Carol A.
Thrall, Roger S.
Publication Title: 
Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

BACKGROUND: The effect of ageing on several pathologic features of allergic asthma (pulmonary inflammation, eosinophilia, mucus hypersecretion), and their relationship with airway hyperresponsiveness (AHR) is not well characterized. OBJECTIVE: To evaluate lung inflammation, mucus metaplasia and AHR in relationship with age in murine models of allergic asthma comparing young and older mice. METHODS: Young (6 weeks) and older (6, 12, 18 months) BALB/c mice were sensitized and challenged with ovalbumin (OVA).

Author(s): 
Busse, Paula J.
Zhang, Teng Fei
Srivastava, Kamal
Schofield, Brian
Li, Xiu-Min
Publication Title: 
Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology

BACKGROUND: Chronic allergic asthma is the result of a T-helper type 2 (Th2)-biased immune status. Current asthma therapies control symptoms in some patients, but a long-lasting therapy has not been established. Anti-Asthma Simplified Herbal Medicine Intervention (ASHMI™), a Chinese herbal formula, improved symptoms and lung function, and reduced Th2 responses in a controlled trial of patients with persistent moderate to severe asthma.

Author(s): 
Srivastava, K.
Zhang, T.
Yang, N.
Sampson, H.
Li, X. M.
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Vitamin D receptor (VDR) deficiency (knockout [KO]) results in a failure of mice to generate an airway hyperreactivity (AHR) response on both the BALB/c and C57BL/6 background. The cause of the failed AHR response is the defective population of invariant NKT (iNKT) cells in the VDR KO mice because wild-type (WT) iNKT cells rescued the AHR response. VDR KO mice had significantly fewer iNKT cells and normal numbers of T cells in the spleen compared with WT mice. In BALB/c VDR KO mice, the reduced frequencies of iNKT cells were not apparent in the liver or thymus.

Author(s): 
Yu, Sanhong
Zhao, Jun
Cantorna, Margherita T.
Publication Title: 
Immunology

Asthma is a chronic disease characterized by airway inflammation caused by the dysregulated production of cytokines secreted by allergen-specific type 2 T helper (Th2) cells. Antrodia camphorata is a commonly used fungus in Asian folk medicine, and A. camphorata polysaccharides are reported to possess anti-cancer activities. In this study, the immunomodulatory effects of purified fractionated polysaccharides (GF2) from A. camphorata on dendritic cells (DCs) and their potential preventive effects against ovalbumin (OVA) -induced asthma were investigated.

Author(s): 
Liu, Ko-Jiunn
Leu, Sy-Jye
Su, Ching-Hua
Chiang, Bor-Luen
Chen, Yi-Lien
Lee, Yueh-Lun
Publication Title: 
International Immunopharmacology

BACKGROUND: Cissampelos sympodialis Eichl. (Menispermaceae) is a plant found in Northeastern and Southeast of Brazil and hot water infusion of C. sympodialis root bark is largely used in the indigenous and folk medicine to treat several inflammatory disorders, including asthma. Asthma is a chronic inflammatory allergic disease characterized by airway hyperreactivity (AHR), eosinophil tissue infiltration and lung remodeling. The aim of this study was to evaluate the therapeutic effect of C.

Author(s): 
Bezerra-Santos, Claudio R.
Vieira-de-Abreu, Adriana
Vieira, Giciane Carvalho
Filho, Jaime R.
Barbosa-Filho, José Maria
Pires, Ana Lucia
Martins, Marco Aurelio
Souza, Heitor S.
Bandeira-Melo, Christianne
Bozza, Patrícia T.
Piuvezam, Marcia R.

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