Burkina Faso

Publication Title: 
Global Public Health

In Burkina Faso, abortion is legally restricted and socially stigmatised, but also frequent. Unsafe abortions represent a significant public health challenge, contributing to the country's very high maternal mortality ratio. Inspired by an internationally disseminated public health framing of unsafe abortion, the country's main policy response has been to provide post-abortion care (PAC) to avert deaths from abortion complications.

Author(s): 
Storeng, Katerini T.
Ouattara, Fatoumata
Publication Title: 
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America

BACKGROUND: Combination antimalarial therapy is advocated to improve treatment efficacy and limit selection of drug-resistant parasites. We compared the efficacies of 3 combination regimens in Bobo-Dioulasso, Burkina Faso: amodiaquine plus sulfadoxine-pyrimethamine, which was recently shown to be highly efficacious at this site; artemether-lumefantrine, the new national first-line antimalarial regimen; and dihydroartemisinin-piperaquine (DP), a newer regimen.

Author(s): 
Zongo, Issaka
Dorsey, Grant
Rouamba, Noel
Dokomajilar, Christian
Séré, Yves
Rosenthal, Philip J.
Ouédraogo, Jean Bosco
Publication Title: 
PloS One

BACKGROUND: Besides existing artemisinin-based combination therapies, alternative safe, effective and affordable drug combinations against falciparum malaria are needed. Methylene blue (MB) was the first synthetic antimalarial drug ever used, and recent studies have been promising with regard to its revival in malaria therapy. The objective of this study was to assess the safety and efficacy of two MB-based malaria combination therapies, MB-artesunate (AS) and MB-amodiaquine (AQ), compared to the local standard of care, AS-AQ, in Burkina Faso.

Author(s): 
Zoungrana, Augustin
Coulibaly, Boubacar
Sié, Ali
Walter-Sack, Ingeborg
Mockenhaupt, Frank P.
Kouyaté, Bocar
Schirmer, R. Heiner
Klose, Christina
Mansmann, Ulrich
Meissner, Peter
Müller, Olaf
Publication Title: 
Tropical medicine & international health: TM & IH

OBJECTIVE: To assess the quality of healthcare workers' performance with regard to malaria diagnosis and treatment and to assess patients' self-medication with chloroquine (CQ) before and after presentation at a health centre. METHODS: In the rainy season 2004, in five rural dispensaries in Burkina Faso, we observed 1101 general outpatient consultations and re-examined all these patients. CQ whole blood concentrations of confirmed malaria cases were measured before and after treatment.

Author(s): 
Pfeiffer, K.
Some, F.
Müller, O.
Sie, A.
Kouyaté, B.
Haefeli, W. E.
Zoungrana, A.
Gustafsson, L. L.
Tomson, G.
Sauerborn, R.
Publication Title: 
Malaria Journal

BACKGROUND: There is concern about an increasing infiltration of markets by substandard and fake medications against life-threatening diseases in developing countries. This is particularly worrying with regard to the increasing resistance development of Plasmodium falciparum against affordable anti-malarial medications, which has led to a change to more expensive drugs in most endemic countries.

Author(s): 
Tipke, Maike
Diallo, Salou
Coulibaly, Boubacar
Störzinger, Dominic
Hoppe-Tichy, Torsten
Sié, Ali
Müller, Olaf
Publication Title: 
Malaria Journal

BACKGROUND: Home Management of Malaria (HMM) is one of the key strategies to reduce the burden of malaria for vulnerable population in endemic countries. It is based on the evidence that well-trained communities health workers can provide prompt and adequate care to patients close to their homes. The strategy has been shown to reduce malaria mortality and severe morbidity and has been adopted by the World Health Organization as a cornerstone of malaria control in Africa.

Author(s): 
Tiono, Alfred B.
Kaboré, Youssouf
Traoré, Abdoulaye
Convelbo, Nathalie
Pagnoni, Franco
Sirima, Sodiomon B.
Publication Title: 
Malaria Journal

BACKGROUND: Artesunate (AS) plus amodiaquine (AQ) is one artemisinin-based combination (ACT) recommended by the WHO for treating Plasmodium falciparum malaria. Fixed-dose AS/AQ is new, but its safety and efficacy are hitherto untested. METHODS: A randomized, open-label trial was conducted comparing the efficacy (non-inferiority design) and safety of fixed (F) dose AS (25 mg)/AQ (67.5 mg) to loose (L) AS (50 mg) + AQ (153 mg) in 750, P. falciparum-infected children from Burkina Faso aged 6 months to 5 years. Dosing was by age.

Author(s): 
Sirima, Sodiomon B.
Tiono, Alfred B.
Gansané, Adama
Diarra, Amidou
Ouédraogo, Amidou
Konaté, Amadou T.
Kiechel, Jean René
Morgan, Caroline C.
Olliaro, Piero L.
Taylor, Walter R. J.
Publication Title: 
PloS One

BACKGROUND: With the availability of new preventive and curative interventions, global malaria control has been strengthened significantly in recent years. Drugs effective in reducing malaria gametocytaemia might contribute to local elimination and possible long-term eradication. We here report on the effects of methylene blue (MB)-based malaria combination therapy on gametocytaemia during a randomised-controlled trial in Burkina Faso.

Author(s): 
Coulibaly, Boubacar
Zoungrana, Augustin
Mockenhaupt, Frank P.
Schirmer, R. Heiner
Klose, Christina
Mansmann, Ulrich
Meissner, Peter E.
Müller, Olaf
Publication Title: 
Malaria Journal

BACKGROUND: Effective and timely treatment is an essential aspect of malaria control, but remains a challenge in many parts of sub-Saharan Africa. The objective of this study was to describe young children's access to malaria treatment in Nouna Health District, Burkina Faso. METHODS: In February/March 2006, a survey was conducted in a representative sample of 1,052 households.

Author(s): 
Tipke, Maike
Louis, Valérie R.
Yé, Maurice
De Allegri, Manuela
Beiersmann, Claudia
Sié, Ali
Mueller, Olaf
Jahn, Albrecht
Publication Title: 
Antimicrobial Agents and Chemotherapy

Artemether-lumefantrine (AL), dihydroartemisinin-piperaquine (DP), and amodiaquine-sulfadoxine-pyrimethamine (AQ-SP) offer excellent antimalarial efficacy but may select for parasite polymorphisms that decrease drug sensitivity. We evaluated the selection of known polymorphisms in genes encoding putative transporters (pfcrt and pfmdr1) and SP targets (pfdhfr and pfdhps) in parasites that caused new infections within 42 days of therapy for uncomplicated falciparum malaria in Burkina Faso.

Author(s): 
Somé, Anyirékun Fabrice
Séré, Yves Y.
Dokomajilar, Christian
Zongo, Issaka
Rouamba, Noel
Greenhouse, Bryan
Ouédraogo, Jean-Bosco
Rosenthal, Philip J.

Pages

Subscribe to RSS - Burkina Faso