Cadmium

Publication Title: 
Research Communications in Chemical Pathology and Pharmacology

Cadmium administration potentiates the duration of hexobarbital-induced hypnosis and inhibits the rate of hepatic microsomal metabolism of this drug in the male rat. The threshold dose of cadmium required to produce these alterations in drug action is 0.84 mg Ck/kg. If subthreshold doses of cadmium (0.21 or 0.42 mg Cd/kg) are administered prior to the 0.84 mg Cd/kg dose, the cadmium-induced alterations in drug action are no longer observed.

Author(s): 
Roberts, S. A.
Miya, T. S.
Schnell, R. C.
Publication Title: 
Toxicology

3 days after pretreatment of rats of both sexes with cadmium (2 mg/kg, 1.p.) the duration of hypnosis induced by hexobarbital (75 mg/kg, 1.p.) was potentiated in males but not females. Likewise similar treatment with cadmium leads to significant inhibition of the metabolism of hexobarbital by hepatic microsomal enzymes obtained from male but not female animals. These data suggest that there is a sex-related difference in the ability of cadmium to alter drug action in rats.

Author(s): 
Schnell, R. C.
Pence, D. H.
Prosser, T. D.
Miya, T.
Publication Title: 
Research Communications in Chemical Pathology and Pharmacology

Pretreatment of male rats with cadmium acetate potentiates the duration of hexobarbital hypnosis and inhibits the rate of hepatic microsomal drug metabolism. Pretreatment of rats with zinc acetate protects against these alterations in drug action elicited by cadmium.

Author(s): 
Early, J. L.
Schnell, R. C.
Publication Title: 
Archives of Toxicology

The effect of acute and chronic cadmium administration on hepatic drug metabolism was investigated in the male rat. 3 days after the acute administration of cadmium by either the intraperitoneal (0.84 mg Cd/kg) or the oral (greater than 80 mg Cd/kg) route, there was a significant potentiation in duration of hexobarbital hypnosis and inhibition of hepatic microsomal metabolism of hexobarbital and aniline.

Author(s): 
Schnell, R. C.
Yuhas, E. M.
Pence, D. H.
Means, J. R.
Roberts, S. A.
Yau, E. T.
Miya, T. S.
Mennear, J. H.
Publication Title: 
Research Communications in Chemical Pathology and Pharmacology

Following the administration of cadmium (2 mg/kg) neither the duration of hypnosis nor the in vivo rate of tissue decline of ethanol was altered. These results differ from the cadmium-induced alterations in biological response and metabolism of other centrally acting drugs.

Author(s): 
Deimling, M. J.
Schnell, R. C.
Publication Title: 
Research Communications in Chemical Pathology and Pharmacology

Pretreatment of rats with cadmium potentiates the duration of hexobarbital hypnosis and inhibits the rate of hepatic hexobarbital metabolism in male and female rats. In contrast, treatment with cadmium pe and female rats. Thus, sex-related differences in cadmium inhibition of hepatic drug metabolism is apparently substrate dependent.

Author(s): 
Pence, D. H.
Schnell, R. C.
Publication Title: 
Analytical Sciences: The International Journal of the Japan Society for Analytical Chemistry

A wax-impregnated carbon paste electrode with mercury oxalate as the bulk modifier is found to be suitable for the determination of heavy metal ions by differential pulse anodic stripping voltammetry. The contents of binder and modifier have been optimized, until they showed low background current and easy renewability. The bulk-modified electrode is applied for the simultaneous determination of Zn, Cd, Pb and Cu in medicinal plants and Ayurvedic tablets (Liv 52). The results obtained have been validated with HMDE and AAS and are found to be comparable.

Author(s): 
Mascarenhas, Ronald J.
Satpati, Ashis K.
Yellappa, Shivaraj
Sherigara, Bailure S.
Bopiah, Ajjikuttira K.
Publication Title: 
PloS One

BACKGROUND: Concern has recently emerged regarding the safety of natural health products (NHPs)-therapies that are increasingly recommended by various health providers, including conventional physicians. Recognizing that most individuals in the Western world now consume vitamins and many take herbal agents, this study endeavored to determine levels of toxic element contamination within a range of NHPs.

Author(s): 
Genuis, Stephen J.
Schwalfenberg, Gerry
Siy, Anna-Kristen J.
Rodushkin, Ilya
Publication Title: 
Biological Trace Element Research

Medicinal plants described in the Indian "Ayurvedic" literature viz. Tulsi (Ocimum sanctum), Gulvel (Tinospora cardifolia), bitter Neem (Azadirachta indica), Kanher (Nerium Andicum), Vekhand (Acorus calamus), and Peacock's feather (ash) were analyzed for minor and trace elements by instrumental neutron activation analysis.

Author(s): 
Samudralwar, D. L.
Garg, A. N.
Publication Title: 
Analytical Sciences: The International Journal of the Japan Society for Analytical Chemistry

A wax-impregnated carbon paste electrode with mercury oxalate as the bulk modifier is found to be suitable for the determination of heavy metal ions by differential pulse anodic stripping voltammetry. The contents of binder and modifier have been optimized, until they showed low background current and easy renewability. The bulk-modified electrode is applied for the simultaneous determination of Zn, Cd, Pb and Cu in medicinal plants and Ayurvedic tablets (Liv 52). The results obtained have been validated with HMDE and AAS and are found to be comparable.

Author(s): 
Mascarenhas, Ronald J.
Satpati, Ashis K.
Yellappa, Shivaraj
Sherigara, Bailure S.
Bopiah, Ajjikuttira K.

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