Caffeic Acids

Publication Title: 
Medicinal Chemistry (Shariqah (United Arab Emirates))

Ethanolic extracts of 30 Thai medicinal plants, traditionally used as alternative treatments in diabetes, were evaluated for antioxidative activity by the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) method. They were evaluated in vitro for oxidative stress by thiobarbituric acid-reactive substance (TBARS) assay in pooled plasma of diabetic patients compared to without treatment of the extracts (control). The extracts were also assayed for protein glycation. The results showed that five plants had strong antioxidant activity: Phyllanthus emblica Linn.

Author(s): 
Kusirisin, W.
Srichairatanakool, S.
Lerttrakarnnon, P.
Lailerd, N.
Suttajit, M.
Jaikang, C.
Chaiyasut, C.
Publication Title: 
Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

OBJECTIVE: To study the chemical constituents in rhizome of Matteuccia struthiopteris. METHOD: The compounds were isolated by normal phase silica gel chromatography. The structures were identified by physical and spectral data. RESULT: Six compounds were isolated and identified as woodwardic acid (1), ergost-6,22-diene-3beta,5alpha,8alpha-triol (2), apigenin (3), riboflavin (4), 4-O-beta-D-glucopyranosyl-p-coumaric acid (5), 4-O-beta-D-glucopyranosylcaffeic acid (6). CONCLUSION: All the compounds were obtained from this plant for the first time.

Author(s): 
Yang, Lan
Wang, Man-Yuan
Zhao, Yu-ying
Tu, You-you
Publication Title: 
Phytochemical analysis: PCA

INTRODUCTION: Withania somnifera (Ashwagandha) is a high-value Ayurvedic medicinal plant and an important constituent of several dietary supplements. In order to substantiate the health claims, the herb has drawn considerable scientific attention. OBJECTIVE: The objective of the study was to investigate the alterations in primary and secondary metabolites of W. somnifera fruits during its maturity using NMR spectroscopy.

Author(s): 
Sidhu, O. P.
Annarao, Sanjay
Chatterjee, Sandipan
Tuli, Rakesh
Roy, Raja
Khetrapal, C. L.
Publication Title: 
Phytochemical analysis: PCA

INTRODUCTION: Earlier studies reported serotonergic activity for cimicifugic acids (CA) isolated from Cimicifuga racemosa. The discovery of strongly basic alkaloids, cimipronidines, from the active extract partition and evaluation of previously employed work-up procedures has led to the hypothesis of strong acid/base association in the extract. OBJECTIVE: Re-isolation of the CAs was desired to permit further detailed studies. Based on the acid/base association hypothesis, a new separation scheme of the active partition was required, which separates acids from associated bases.

Author(s): 
Gödecke, Tanja
Nikolic, Dejan
Lankin, David C.
Chen, Shao-Nong
Powell, Sharla L.
Dietz, Birgit
Bolton, Judy L.
van Breemen, Richard B.
Farnsworth, Norman R.
Pauli, Guido F.
Publication Title: 
Experimental Biology and Medicine (Maywood, N.J.)

Susceptibility to inflammatory bowel diseases depends upon interactions between the genetics of the individual and induction of chronic mucosal inflammation. We hypothesized that administration of dietary phenolics, caffeic acid and rutin, would suppress upregulation of inflammatory markers and intestinal damage in a mouse model of colitis. Colitis was induced in C3H/ HeOuJ mice (8 weeks old, 6 male/6 female per treatment) with 1.25% dextran sulfate sodium (DSS) for 6 d in their drinking water.

Author(s): 
Ye, Zhong
Liu, Zhiping
Henderson, Abigail
Lee, Kwangwon
Hostetter, Jesse
Wannemuehler, Michael
Hendrich, Suzanne
Publication Title: 
Current Drug Safety

Black cohosh (Actaea racemosa L. [syn. Cimifuga racemosa L.]) extracts (BCE) are marketed worldwide for the management of menopausal symptoms. However, recently more than 75 cases of hepatotoxicity associated with black cohosh ingestion have been reported. While these cases have not been fully substantiated for causality, the data suggest that herb-drug interactions may be involved rather than a direct hepatotoxic event. This work describes the in vitro inhibition of four CYP450 enzymes (1A2, 2D6, 2C9, 3A4) by black cohosh extracts and identifies the active inhibitory constituents.

Author(s): 
Huang, Yue
Jiang, Bei
Nuntanakorn, Paiboon
Kennelly, Edward J.
Shord, Stacy
Lawal, Temitope O.
Mahady, G. B.
Publication Title: 
Planta Medica

Echinacea species are used for beneficial effects on immune function, and various prevalent phytochemicals have immunomodulatory effects. Using a commercial E. purpurea (L.) Moench product, we have evaluated the myelopoietic effect on bone marrow of rats treated with various extracts and correlated this with their chemical class composition. Granulocyte/macrophage-colony forming cells (GM-CFCs) from femurs of female Sprague-Dawley rats were assessed at 24 h after 7 daily oral treatments.

Author(s): 
Ramasahayam, Sindhura
Baraka, Hany N.
Abdel Bar, Fatma M.
Abuasal, Bilal S.
Widrlechner, Mark P.
Sayed, Khalid A. El
Meyer, Sharon A.
Publication Title: 
Cancer Research

Caffeic acid phenethyl ester (CAPE) was isolated from propolis (a product of honeybee hives) that has been used in folk medicine as a potent antiinflammatory agent. CAPE is cytotoxic to tumor and virally transformed but not to normal cells. Our main goal was to establish whether CAPE inhibits the tumor promoter (12-O-tetradecanoylphorbol-13-acetate)-induced processes associated with carcinogenesis.

Author(s): 
Frenkel, K.
Wei, H.
Bhimani, R.
Ye, J.
Zadunaisky, J. A.
Huang, M. T.
Ferraro, T.
Conney, A. H.
Grunberger, D.
Publication Title: 
Acta Crystallographica. Section F, Structural Biology and Crystallization Communications

Phospholipases A(2) (PLA(2)s) are one of the main components of bothropic venoms; in addition to their phospholipid hydrolysis action, they are involved in a wide spectrum of pharmacological activities, including neurotoxicity, myotoxicity and cardiotoxicity. Caffeic acid is an inhibitor that is present in several plants and is employed for the treatment of ophidian envenomations in the folk medicine of many developing countries; as bothropic snake bites are not efficiently neutralized by conventional serum therapy, it may be useful as an antivenom.

Author(s): 
Shimabuku, Patrícia S.
Fernandes, Carlos A. H.
Magro, Angelo J.
Costa, Tássia R.
Soares, Andreimar M.
Fontes, Marcos R. M.
Publication Title: 
The Journal of Toxicological Sciences

Cadmium (Cd) is classified as an environmental pollutant and human carcinogen. Caffeic acid phenethyl ester (CAPE), a biological active component of honeybee propolis extracts, has been used as a folk medicine with no harmful effects on normal cells. Here we investigated the beneficial effect of CAPE on Cd-induced renal damage in mice. Since renal damage induced by Cd (II) is related to oxidative stress, lipid peroxidation (LPO), protein carbonyl (PCO), superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) were evaluated.

Author(s): 
Gong, Pin
Chen, Fuxin
Liu, Xiaoying
Gong, Xing
Wang, Jing
Ma, Yangmin

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