Calcium Channel Blockers

Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Breech presentation is associated with increased complications. Turning a breech baby to head first presentation using external cephalic version (ECV) attempts to reduce the chances of breech presentation at birth so as to avoid the adverse effects of breech vaginal birth or caesarean section. Interventions such as tocolytic drugs and other methods have been used in an attempt to facilitate ECV.

Author(s): 
Cluver, Catherine
Gyte, Gillian M. L.
Sinclair, Marlene
Dowswell, Therese
Hofmeyr, G. Justus
Publication Title: 
Archives of Physical Medicine and Rehabilitation

OBJECTIVES: To present an evidence-based overview of the effectiveness of (non)surgical symptomatic interventions to treat secondary Raynaud's phenomenon (RP). DATA SOURCES: The Cochrane Library, PubMed, Embase, PEDro, and CINAHL were searched for relevant systematic reviews and randomized controlled trials (RCTs). STUDY SELECTION: Two reviewers independently applied the inclusion criteria to select potential studies. DATA EXTRACTION: Two reviewers independently extracted data and assessed the methodologic quality.

Author(s): 
Huisstede, Bionka M.
Hoogvliet, Peter
Paulis, Winifred D.
van Middelkoop, Marienke
Hausman, Michael
Coert, J. Henk
Koes, Bart W.
Publication Title: 
Drugs

Tourette's disorder is a neuropsychiatric disorder characterised clinically by motor and vocal tics, which may be associated to conductual disorders such as obsessive-compulsive disorder (OCD) and attention-deficit hyperactivity disorder (ADHD). Although the neurochemistry of Tourette's disorder is not well known, there are some effective therapies for tics, OCD and ADHD. However, these are not devoid of adverse effects. Tics only require treatment when they interfere with the functioning of the patient.

Author(s): 
Jiménez-Jiménez, F. J.
García-Ruiz, P. J.
Publication Title: 
Journal of Neural Transmission (Vienna, Austria: 1996)

In order to elucidate the mechanism(s) behind the interactions between barbiturates and Ca(2+) antagonists, the effects of three structurally diverse types of Ca(2+) antagonists combined or not with 5-HT on pentobarbital-induced hypnosis in mice were investigated.

Author(s): 
Zhao, X.
Cui, X.-Y.
Chu, Q.-P.
Chen, B.-Q.
Wang, X.-M.
Lin, Z.-B.
Li, X.-J.
Ku, B.-S.
Zhang, Y.-H.
Publication Title: 
Neuropharmacology

To investigate the mechanism by which L-type Ca+ channel blockers exerted potentiating effects on pentobarbital-induced hypnosis, the present study was undertaken to determine if the interaction of diltiazem and serotonergic system influences the architecture of pentobarbital sleep in rats and examined c-Fos expression in the ventrolateral preoptic nucleus (VLPO) and the tuberomammillary nucleus (TMN). The polysomnogram consisting of EEG and EMG was recorded for analyzing sleep architecture.

Author(s): 
Zhao, Xin
Cui, Xiang-Yu
Wang, Li-En
Zhang, Yong-He
Publication Title: 
Brain Research

Our previous studies indicated that L-type calcium channel blocker diltiazem could potentiate pentobarbital-induced hypnosis through serotonergic system. In view of the important role of dorsal raphe nucleus (DRN) on the sleep regulation and the pharmacological actions of calcium channel blocker, we presumed that Ca(2+) in the DRN may play an important role in sleep regulation in pentobarbital treated rats.

Author(s): 
Cui, Su-Ying
Cui, Xiang-Yu
Zhang, Juan
Wang, Zi-Jun
Yu, Bin
Sheng, Zhao-Fu
Zhang, Xue-Qiong
Shi, Xiao-Lei
Zhang, Yong-He
Publication Title: 
Pharmacology, Biochemistry, and Behavior

It has been reported that the sedative component of pentobarbital is mediated by GABA receptors in an endogenous sleep pathway and the ventrolateral preoptic area (VLPO)-tuberomammillary nucleus (TMN) or VLPO-dorsal raphe nucleus (DRN) neural circuit is important in the sedative response to pentobarbital. Our previous findings indicated that the VLPO-TMN neuronal circuit may play crucial part in the augmentative effect of diltiazem on pentobarbital sleep and the serotonergic system may be involved.

Author(s): 
Cui, Su-Ying
Cui, Xiang-Yu
Zhang, Juan
Wang, Zi-Jun
Yu, Bin
Sheng, Zhao-Fu
Zhang, Xue-Qiong
Shi, Xiao-Lei
Zhang, Yong-He
Publication Title: 
Neuropharmacology

Thalamocortical (TC) neurons provide the major sensory input to the mammalian somatosensory cortex. Decreased activity of these cells may be pivotal in the ability of general anesthetics to induce loss of consciousness and promote sleep (hypnosis). T-type voltage-gated calcium currents (T-currents) have a key function regulating the cellular excitability of TC neurons and previous studies have indicated that volatile general anesthetics may alter the excitability of these neurons.

Author(s): 
Eckle, Veit-Simon
Digruccio, Michael R.
Uebele, Victor N.
Renger, John J.
Todorovic, Slobodan M.
Publication Title: 
The Cochrane Database of Systematic Reviews

BACKGROUND: Breech presentation is associated with increased complications. Turning a breech baby to head first presentation using external cephalic version (ECV) attempts to reduce the chances of breech presentation at birth so as to avoid the adverse effects of breech vaginal birth or caesarean section. Interventions such as tocolytic drugs and other methods have been used in an attempt to facilitate ECV.

Author(s): 
Cluver, Catherine
Gyte, Gillian M. L.
Sinclair, Marlene
Dowswell, Therese
Hofmeyr, G. Justus
Publication Title: 
Acta Pharmacologica Sinica

AIM: To compare the effects of matrine, artemisinin, and tetrandrine on intracellular Ca2+ concentration ([Ca2+]i) in guinea pig ventricular myocytes. METHODS: A single ventricular myocyte was loaded with Fluo 3-acetoxymethyl (Fluo 3-AM). [Ca2+]i was recorded by laser scanning confocal microscope and represented by fluorescence intensity (FI). RESULTS: 1) KCl 60 mmol . L-1 elevated the FI from 299 +/ -19 to 1389 +/- 325 (P < 0.01) in the presence of extracellular Ca2+ 1.8 mmol . L-1. 2) Both matrine and artemisinin at the concentration of 100 micromol .

Author(s): 
Ai, J.
Gao, H. H.
He, S. Z.
Wang, L.
Luo, D. L.
Yang, B. F.

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