Calcium Channels, L-Type

Publication Title: 
Translational Psychiatry

Depressive disorders have been shown to be highly influenced by environmental pathogenic factors, some of which are believed to exert stress on human brain functioning via epigenetic modifications. Previous genome-wide methylomic studies on depression have suggested that, along with differential DNA methylation, affected co-twins of monozygotic (MZ) pairs have increased DNA methylation variability, probably in line with theories of epigenetic stochasticity. Nevertheless, the potential biological roots of this variability remain largely unexplored.

Author(s): 
CÛrdova-Palomera, A.
FatjÛ-Vilas, M.
GastÛ, C.
Navarro, V.
Krebs, M.-O.
FaÒan·s, L.
Publication Title: 
British Journal of Pharmacology

Clinical studies suggest that the Ayurvedic plant Boswellia serrata may be effective in reducing diarrhoea in patients with inflammatory bowel disease. In the present study, we evaluated the effect of a Boswellia serrata gum resin extract (BSE) on intestinal motility and diarrhoea in rodents. BSE depressed electrically-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum, being more potent in inhibiting the contractions induced by acetylcholine and barium chloride.

Author(s): 
Borrelli, Francesca
Capasso, Francesco
Capasso, Raffaele
Ascione, Valeria
Aviello, Gabriella
Longo, Rocco
Izzo, Angelo A.
Publication Title: 
British Journal of Pharmacology

Clinical studies suggest that the Ayurvedic plant Boswellia serrata may be effective in reducing diarrhoea in patients with inflammatory bowel disease. In the present study, we evaluated the effect of a Boswellia serrata gum resin extract (BSE) on intestinal motility and diarrhoea in rodents. BSE depressed electrically-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum, being more potent in inhibiting the contractions induced by acetylcholine and barium chloride.

Author(s): 
Borrelli, Francesca
Capasso, Francesco
Capasso, Raffaele
Ascione, Valeria
Aviello, Gabriella
Longo, Rocco
Izzo, Angelo A.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Withania somnifera (WS) root extract has been used traditionally in ayurvedic system of medicine as a memory enhancer and anti-stress agent. AIM OF THE STUDY: To evaluate the neuroprotective and prophylactic potential of WS root extract in ameliorating hypobaric hypoxia (HH) induced memory impairment and to explore the underlying molecular mechanism. MATERIALS AND METHODS: WS root extract was administered to male Sprague Dawley rats during a period of 21 days pre-exposure and 07 days exposure to a simulated altitude of 25,000 ft.

Author(s): 
Baitharu, Iswar
Jain, Vishal
Deep, Satya Narayan
Hota, Kalpana Barhwal
Hota, Sunil Kumar
Prasad, Dipti
Ilavazhagan, Govindasamy
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

External application of static magnetic fields (SMF), used specifically for the treatment of inflammatory conditions such as soft tissue injuries, has recently become popular as a complementary and/or alternative therapy with minimal investigation into efficacy or mechanism. Localized inflammation was induced via injection of inflammatory agents lambda-carrageenan (CA) or histamine into rat hindpaws, alone or in conjunction with pharmacological agents, resulting in a spatially and temporally defined inflammatory reaction.

Author(s): 
Morris, Cassandra E.
Skalak, Thomas C.
Publication Title: 
PloS One

Clinical trials and epidemiological studies have suggested that dietary fish oil (FO) supplementation can provide an anti-arrhythmic benefit in some patient populations. The underlying mechanisms are not entirely clear. We wanted to understand how FO supplementation (for 4 weeks) affected the action potential configuration/duration of ventricular myocytes, and the ionic mechanism(s)/molecular basis for these effects. The experiments were conducted on adult rabbits, a widely used animal model for cardiac electrophysiology and pathophysiology.

Author(s): 
Xu, Xulin
Jiang, Min
Wang, Yuhong
Smith, Timothy
Baumgarten, Clive M.
Wood, Mark A.
Tseng, Gea-Ny
Publication Title: 
Neurobiology of Disease

There is strong evidence that intracellular calcium dysregulation plays an important pathological role in Alzheimer's disease, and specifically that beta amyloid may induce increases in intracellular calcium and lead to neuronal cell dysfunction and death. Here we investigated the feasibility of modifying Alzheimer's pathology with the L-type voltage-gated calcium channel blockers verapamil, diltiazem, isradipine and nimodipine. All four compounds protected MC65 neuroblastoma cells from amyloid beta protein precursor C-terminal fragment (APP CTF)-induced neurotoxicity.

Author(s): 
Anekonda, Thimmappa S.
Quinn, Joseph F.
Harris, Christopher
Frahler, Kate
Wadsworth, Teri L.
Woltjer, Randall L.
Publication Title: 
Disease Models & Mechanisms

A growing body of evidence supports the 'calcium hypothesis' of Alzheimer's disease (AD), which postulates that a variety of insults might disrupt the homeostatic regulation of neuronal calcium (Ca(2+)) in the brain, resulting in the progressive symptoms that typify the disease. However, despite ongoing efforts to develop new methods for testing therapeutic compounds that might be beneficial in AD, no single bioassay permits both rapid screening and in vivo validation of candidate drugs that target specific components of the Ca(2+) regulatory machinery.

Author(s): 
Copenhaver, Philip F.
Anekonda, Thimmappa S.
Musashe, Derek
Robinson, Kristine M.
Ramaker, Jenna M.
Swanson, Tracy L.
Wadsworth, Teri L.
Kretzschmar, Doris
Woltjer, Randall L.
Quinn, Joseph F.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Brazilian folk medicine uses infusion of Costus spiralis leaf to help people to treat arterial hypertension and syndromes of cardiac hyperexcitability. AIM OF THE STUDY: Evaluate the aqueous fraction (AqF) effect on atrial contractility and investigate its mechanism of action. MATERIALS AND METHODS: The AqF effect on the cardiac contractility was studied on isolated electrically driven guinea pig left atria. Atropine and tetraethylammonium (TEA) were employed to investigate whether potassium contributes for the inotropic mechanism of the AqF.

Author(s): 
Britto, Raquel Moreira
Santos, André Luiz
Cruz, Jader Santos
Gondim, Antonio Nei Santana
Lauton-Santos, Sandra
Lara, Aline
Guatimosim, Silvia
Vasconcelos, Carla Maria Lins
Estevam, Charles Dos Santos
Dias, Antonio Santos
Oliveira, Evaleide Diniz
Lima, Adriana Karla
Souza, Rejane Cardoso
Conde-Garcia, Eduardo Antonio
Publication Title: 
FEBS letters

The dihydropyridine receptor (DHPR), a voltage-gated L-type Ca2+ channel, and the Ca2+ release channel/ryanodine receptor isoform-1 (RyR1) are key molecules involved in skeletal muscle excitation-contraction coupling. We have reported age-related decreases in the level of DHPR expression in fast- and slow-twitch muscles from Fisher 344 cross Brown Norway (F344BNX) rats (Renganathan, Messi and Delbono, J. Membr. Biol. 157 (1997) 247-253).

Author(s): 
Renganathan, M.
Delbono, O.

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