Calorimetry, Differential Scanning

Publication Title: 
AAPS PharmSciTech

The purpose of this research was to mask the intensely bitter taste of artemether (ARM) and to formulate a rapid-disintegrating tablet (RDT) of the taste-masked drug. Taste masking was done by solid dispersion with mono amino glycyrrhyzinate pentahydrate (GLY) by solvent evaporation method. To characterize and formulate taste masked rapid disintegrating tablets (RDTs) of ARM, the 1:1M solid dispersion was selected based on bitterness score.

Author(s): 
Shah, Punit P.
Mashru, Rajashree C.
Publication Title: 
Chemical & Pharmaceutical Bulletin

The main objective of this research is to improve the dissolution rate of artemisinin (ART) by fabrication with ?-cyclodextrin (?-CD) as a hydrophilic carrier. Artemisinin nanoparticles and ART/?-CD complexes were successfully fabricated by means of evaporative precipitation of nanosuspension. Characterization of the samples was done by scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and dissolution tester.

Author(s): 
Kakran, Mitali
Sahoo, Nanda Gopal
Li, Lin
Judeh, Zaher
Publication Title: 
AAPS PharmSciTech

Artemisinin, a poorly water-soluble antimalarial drug, presents a low and erratic bioavailability upon oral administration. The aim of this work was to study an agglomerated powder dosage form for oral administration of artemisinin based on the artemisinin/?-cyclodextrin primary microparticles. These primary microparticles were prepared by spray-drying a water-methanol solution of artemisinin/?-cyclodextrin. ?-Cyclodextrin in spray-dried microparticles increased artemisinin water apparent solubility approximately sixfold.

Author(s): 
Balducci, Anna Giulia
Magosso, Enrico
Colombo, Gaia
Sonvico, Fabio
Khan, Nurzalina Abdul Karim
Yuen, Kah Hay
Bettini, Ruggero
Colombo, Paolo
Rossi, Alessandra
Publication Title: 
Journal of Pharmaceutical and Biomedical Analysis

The purpose of this study was to simultaneously improve the solubility and stability of dihydroartemisinin (DHA) in aqueous solutions by a ternary cyclodextrin system comprised of DHA, hydroxypropyl-?-cyclodextrin (HP-?-CD) and a third auxiliary substance. Solubility and phase solubility studies were carried out to evaluate the solubilizing efficiency of HP-?-CD in association with various auxiliary substances.

Author(s): 
Wang, Dan
Li, Haiyan
Gu, Jingkai
Guo, Tao
Yang, Shuo
Guo, Zhen
Zhang, Xueju
Zhu, Weifeng
Zhang, Jiwen
Publication Title: 
Acta Poloniae Pharmaceutica

Artemisinin (ARMN) is a potent antimalarial drug, which is effective against multidrug resistant strains of Plasmodium falciparum and produces rapid recovery even in patients with cerebral malaria. Being poorly soluble in water, artemisinin is incompletely absorbed after oral intake due to poor dissolution characteristics in the intestinal fluids. To enhance these properties, solid dispersions of artemisinin with succinic acid (SUC) were prepared using drug-carrier ratios 1 : 1, 1 : 4, 1 : 6, 1 : 8 and 1 : 10 by solvent evaporation and freeze drying methods.

Author(s): 
Ansari, Muhammad Tayyab
Pervez, Humayun
Shehzad, Muhammad Tariq
Saeed-ul-Hassan, Syed
Mehmood, Zahid
Shah, Syed Nisar Hussain
Razi, Muhammad Tahir
Murtaza, Ghulam
Publication Title: 
The Journal of Surgical Research

BACKGROUND: Wound infection is a major problem in the medical community since many types of wounds are more prone to microbial contamination leading to infection. Triphala (a traditional ayurvedic herbal formulation) incorporated collagen sponge was investigated for its healing potential on infected dermal wound in albino rats. MATERIALS AND METHODS: Methanol extract of triphala was prepared and analyzed for the presence of catechin by high-pressure liquid chromatography analysis. Collagen sponge was prepared by incorporating triphala into collagen sponge.

Author(s): 
Kumar, Muthusamy Senthil
Kirubanandan, Shanmugam
Sripriya, Ramasamy
Sehgal, Praveen Kumar
Publication Title: 
Chemical & Pharmaceutical Bulletin

The objective of the present work was to study the preparation, optimization and characteristics of Huperzine A (Hup A), an effective Traditional Chinese Medicine treatment of Alzheimer's disease (AD), loaded nanostructured lipid carriers (NLC). NLC were successfully prepared by a modified method of melt ultrasonication followed by high pressure homogenization using Cetyl Palmitate (CP) as the solid lipid, Miglyol((R))812 as the liquid lipid, Soybean phosphatidylcholine (Spc) and Solutol HS15 as the emulsifiers.

Author(s): 
Yang, Chun-Rong
Zhao, Xiu-Li
Hu, Hai-Yang
Li, Ke-Xin
Sun, Xin
Li, Lei
Chen, Da-wei
Publication Title: 
International Journal of Nanomedicine

Icariin is a bioactive herbal ingredient isolated from Herba epimedii, which has been widely used for the treatment of osteoporosis and male sexual dysfunction in traditional Chinese medicine. The major objective of this work is to investigate the different enhancing effects of β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) on the intestinal absorption of icariin, and to identify the molecular mechanisms of this action.

Author(s): 
Zhang, Ye
Wang, Qiang-Song
Cui, Yuan-Lu
Meng, Fan-Cui
Lin, Ke-Ming
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