Publication Title: 
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research

PURPOSE: Milk thistle (Silybum marianum) is one of the most commonly used herbal therapies, and its principal constituent silybin significantly inhibits cytochrome P450 isoform 3A4 (CYP3A4) and UDP glucuronosyltransferase isoform 1A1 (UGT1A1) in vitro. Here, we investigated whether milk thistle affects the pharmacokinetics of irinotecan, a substrate for CYP3A4 and UGT1A1, in humans. EXPERIMENTAL DESIGN: Six cancer patients were treated with irinotecan (dose, 125 mg/m(2)) given as a 90-minute infusion once every week.

van Erp, Nielka P. H.
Baker, Sharyn D.
Zhao, Ming
Rudek, Michelle A.
Guchelaar, Henk-Jan
Nortier, Johan W. R.
Sparreboom, Alex
Gelderblom, Hans
Publication Title: 
Molecular Pharmacology

Carboxylesterases constitute a class of enzymes that play important roles in the hydrolytic metabolism of drugs and other xenobiotics. Patients with liver conditions such as cirrhosis show increased secretion of proinflammatory cytokines [e.g., interleukin-6 (IL-6)] and decreased capacity of hydrolysis. In this study, we provide a molecular explanation linking cytokine secretion directly to the decreased capacity of hydrolytic biotransformation.

Yang, Jian
Shi, Deshi
Yang, Dongfang
Song, Xiulong
Yan, Bingfang
Publication Title: 
The Journal of Pharmacy and Pharmacology

OBJECTIVES: Panaxadiol is a purified sapogenin of ginseng saponins that exhibits anticancer activity. Irinotecan is a second-line anticancer drug, but clinical treatment with irinotecan is limited due to its side effects. In this study, we have investigated the possible synergistic anticancer effects of panaxadiol and irinotecan on human colorectal cancer cells and explored the potential role of apoptosis in their synergistic activity. KEY FINDINGS: The combination of panaxadiol and irinotecan significantly enhanced antiproliferative effects in HCT-116 cells (P< 0.05).

Du, Guang-Jian
Wang, Chong-Zhi
Zhang, Zhi-Yu
Wen, Xiao-Dong
Somogyi, Jacqueline
Calway, Tyler
He, Tong-Chuan
Du, Wei
Yuan, Chun-Su
Publication Title: 
PloS One

Inactivation of the tumor suppressor gene p53 is commonly observed in human prostate cancer and is associated with therapeutic resistance. We have previously demonstrated that green tea polyphenols (GTP) induce apoptosis in prostate cancer cells irrespective of p53 status. However, the molecular mechanisms underlying these observations remain elusive. Here we investigated the mechanisms of GTP-induced apoptosis in human prostate cancer LNCaP cells stably-transfected with short hairpin-RNA against p53 (LNCaPshp53) and control vector (LNCaPshV).

Gupta, Karishma
Thakur, Vijay S.
Bhaskaran, Natarajan
Nawab, Akbar
Babcook, Melissa A.
Jackson, Mark W.
Gupta, Sanjay
Publication Title: 
Journal of Chromatography. A

Traditional Chinese Medicine (TCM) is increasingly being used in combination with Western medicine. In general, TCM is comprised of multiple components in sharp contrast to Western medicine, where a single active chemical is used. Presently, there are no well-established standards for most of the chemical compounds of TCM and their respective metabolites. Moreover, there are no formal analytical methods for the identification of these chemicals, especially in trace amounts.

Zhang, Wei
Saif, Muhammad W.
Dutschman, Ginger E.
Li, Xin
Lam, Wing
Bussom, Scott
Jiang, Zaoli
Ye, Min
Chu, Edward
Cheng, Yung-Chi
Publication Title: 
BMC medical genomics

BACKGROUND: Traditional Chinese Medicine (TCM) has been used for thousands of years to treat or prevent diseases, including cancer. Good manufacturing practices (GMP) and sophisticated product analysis (PhytomicsQC) to ensure consistency are now available allowing the assessment of its utility. Polychemical Medicines, like TCM, include chemicals with distinct tissue-dependent pharmacodynamic properties that result in tissue-specific bioactivity.

Wang, Ena
Bussom, Scott
Chen, Jinguo
Quinn, Courtney
Bedognetti, Davide
Lam, Wing
Guan, Fulan
Jiang, Zaoli
Mark, Yichao
Zhao, Yingdong
Stroncek, David F.
White, Jeffrey
Marincola, Francesco M.
Cheng, Yung-Chi
Publication Title: 
Journal of Natural Products

The roots of Salvia miltiorrhiza ("Danshen") are used in traditional Chinese medicine for the treatment of numerous ailments including cardiovascular disease, hypertension, and ischemic stroke. Extracts of S. miltiorrhiza roots in the formulation "Compound Danshen Dripping Pill" are undergoing clinical trials in the United States. To date, the active components of this material have not been conclusively identified. We have determined that S. miltiorrhiza roots contain potent human carboxylesterase (CE) inhibitors, due to the presence of tanshinones.

Hatfield, M. Jason
Tsurkan, Lyudmila G.
Hyatt, Janice L.
Edwards, Carol C.
Lemoff, Andrew
Jeffries, Cynthia
Yan, Bing
Potter, Philip M.
Publication Title: 
PloS One

OBJECTIVE: The present study was designed to examine the anticancer effect of Traditional Chinese Medicine of polyphyllin I (PPI) and evodiamine (EVO) on freshly-removed gastric tumor tissues. METHODS: Sixty freshly-removed gastric tumor tissues were collected. Their sensitivity to PPI, EVO, platinum (Pt), 5-FU, irinotecan (CPT-11) were determined by histoculture drug response assay (HDRA).

Yue, Guofeng
Wei, Jia
Qian, Xiaoping
Yu, Lixia
Zou, Zhengyun
Guan, Wenxian
Wang, Hao
Shen, Jie
Liu, Baorui
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