Publication Title: 
Journal of Physical Activity & Health

BACKGROUND: The role of social-environmental factors in physical activity (PA) within lower income and ethnic minority populations is understudied. This study explored correlates of age-related PA and perceived walkability (PW). METHODS: Cross-sectional data (N = 401 women; ?18 y) were collected within the Jane-Finch community in Toronto, Ontario using questionnaires. Generalized additive models, an extension to multiple regression, were used to estimate effect sizes and standard errors.

Perez, Daniel F.
Ritvo, Paul G.
Brown, Patrick E.
Holowaty, Eric
Ardern, Chris
Publication Title: 
Age and Ageing

INTRODUCTION: parental age at conception may affect life expectancy. Adult daughters of older fathers seem to live shorter lives and, in one study, being born to a mother aged <25 was an important predictor of exceptional longevity. The effect of parental age on fitness/frailty in late life is unknown. We aimed to investigate the relationships between parental age and frailty and longevity in older adults. METHODS: in the Canadian Study of Health and Aging (CSHA), data was collected on individuals aged >or=65 using a Self-Assessed Risk Factor Questionnaire and screening interview.

Hubbard, Ruth E.
Andrew, Melissa K.
Rockwood, Kenneth
Publication Title: 
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire

My desire as a young endocrinologist to improve my clinical skills through a better knowledge of hormone chemistry led me to serendipitous discoveries and unexpected horizons. The first discovery, published in 1967, revealed that peptide hormones are derived from endoproteolytic cleavages of larger precursor polypeptides. It was the foundation of the prohormone theory.

ChrÈtien, Michel
Publication Title: 

The low rate of coronary heart disease (CHD) in France compared with other developed countries with comparable dietary intake has been called the French paradox. We explored this paradox by looking at alcohol, diet, and mortality data from 21 developed, relatively affluent countries in the years 1965, 1970, 1980, and 1988. We assessed wine, beer, and spirits intake separately. France had the highest wine intake and the highest total alcohol intake, and the second lowest CHD mortality rate.

Criqui, M. H.
Ringel, B. L.
Publication Title: 
Current Opinion in Pulmonary Medicine

From antiquity to the 1920s, the frequency of asthma and especially death from asthma was considered to be rare. In fact, asthma was not considered a significant cause of death during the early years of the 20th century. The Frenchman Armand Trousseau declared in his Clinique Medicale that "asthma n'est pas fatale" ("asthma is not fatal"). In the United States, Oliver Wendell Holmes had described asthma as a "slight ailment that promotes longevity." Clearly this perception of asthma has changed for many reasons.

Meza, C.
Gershwin, M. E.
Publication Title: 
The Gerontologist

PURPOSE: Prevalence estimates of healthy behaviors and preventive care among older adults have not received sufficient attention, despite important health benefits such as longevity and better quality of life. Moreover, little is known about general population prevalences of older adults' efforts to change behavior, motivations to improve health behaviors, and perceived barriers to change.

Newsom, Jason T.
Kaplan, Mark S.
Huguet, Nathalie
McFarland, Bentson H.
Publication Title: 
Journal of Nutrition for the Elderly

Science and technology are modernizing the field of nutrition and are consequently increasing its complexity. New food developments such as fortified foods and functional foods are evidence of its modernization. The increased specificity of nutrient- and food-intake recommendations and the breadth of claims on food packages are evidence of nutrition's growing complexity. Unfortunately, research on the consumer acceptability of new food developments and nutrition education initiatives has not kept pace with advancements in the field.

Paulionis, Lina
Publication Title: 
Journal of psychiatry & neuroscience: JPN

BACKGROUND: Preference for fatty foods is a risk factor for obesity. It is a complex behaviour that involves the brain reward system and is regulated by genetic and environmental factors, such as the opioid receptor mu-1 gene (OPRM1) and prenatal exposure to maternal cigarette smoking (PEMCS). We examined whether OPRM1 and PEMCS interact in influencing fat intake and whether exposure-associated epigenetic modifications of OPRM1 may mediate this gene-environment interaction.

Lee, Ken W. K.
Abrahamowicz, Michal
Leonard, Gabriel T.
Richer, Louis
Perron, Michel
Veillette, Suzanne
Reischl, Eva
Bouchard, Luigi
Gaudet, Daniel
Paus, Tomas
Pausova, Zdenka
Publication Title: 
The World Journal of Biological Psychiatry: The Official Journal of the World Federation of Societies of Biological Psychiatry

OBJECTIVES: About 50% of patients with unipolar depression suffer from treatment-resistant depression (TRD). Animal studies have suggested potential antidepressant properties of valproate (VPA) possibly due to its implication in epigenetic programming. METHODS: Fourteen TRD patients (seven males and seven females; age 19-59) received VPA (375-1000 mg/day) in addition to their treatment regimen after previously failing to respond to two or more antidepressant trials and/or different combinations.

Ghabrash, Maykel F.
Comai, Stefano
Tabaka, John
Saint-Laurent, Marie
Booij, Linda
Gobbi, Gabriella
Publication Title: 
International Journal of Geriatric Psychiatry

When compared to suicide rates in the general population, it may be expected that elderly suicide rates would be lower in Catholic and Orthodox societies than in non-Catholic or non-Orthodox countries because of religious affiliations and extended family traditions. National suicide rates in the general population were compared with rates in the sub-population of those aged over 75 years. Proportionately, there are significantly higher suicide rates in elderly men in Catholic and Orthodox countries, compared to rates in other countries, with a trend for similar findings among women.

Pritchard, C.
Baldwin, D.


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