Cannabinoid Receptor Antagonists

Publication Title: 
Future Medicinal Chemistry

Cannabinoids are a group of compounds that mediate their effects through cannabinoid receptors. The discovery of Δ9-tetrahydrocannabinol (THC) as the major psychoactive principle in marijuana, as well as the identification of cannabinoid receptors and their endogenous ligands, has led to a significant growth in research aimed at understanding the physiological functions of cannabinoids. Cannabinoid receptors include CB1, which is predominantly expressed in the brain, and CB2, which is primarily found on the cells of the immune system.

Author(s): 
Nagarkatti, Prakash
Pandey, Rupal
Rieder, Sadiye Amcaoglu
Hegde, Venkatesh L.
Nagarkatti, Mitzi
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Allogeneic hematopoietic cell transplantation (HCT) is widely used to treat patients with life-threatening malignant and nonmalignant hematological diseases. However, allogeneic HCT often is accompanied by severe and lethal complications from graft-versus-host disease (GVHD), in which activated donor T cells recognize histocompatibility antigenic mismatches and cause significant toxicity in the recipient. In the current study, we tested the hypothesis that activation of cannabinoid receptors on donor-derived T cells may prevent GVHD.

Author(s): 
Pandey, Rupal
Hegde, Venkatesh L.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Marijuana abuse is very prominent among pregnant women. Although marijuana cannabinoids have been shown to exert immunosuppression in adults, virtually nothing is known about the effects of marijuana use during pregnancy on the developing immune system of the fetus and during postnatal life. We noted that murine fetal thymus expressed high levels of the cannabinoid receptors CB1 and CB2.

Author(s): 
Lombard, Catherine
Hegde, Venkatesh L.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
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