Cannabinoid Receptor Modulators

Publication Title: 
Pharmacology, Biochemistry, and Behavior

In anxiety disorders, such as posttraumatic stress disorders and phobias, classical conditioning pairs natural (unconditioned) fear-eliciting stimuli with contextual or discrete cues resulting in enduring fear responses to multiple stimuli. Extinction is an active learning process that results in a reduction of conditioned fear responses after conditioned stimuli are no longer paired with unconditioned stimuli. Fear extinction often produces incomplete effects and this highlights the relative permanence of bonds between conditioned stimuli and conditioned fear responses.

Author(s): 
Kaplan, Gary B.
Moore, Katherine A.
Publication Title: 
The European Journal of Neuroscience

Prenatal development is highly sensitive to maternal drug use due to the vulnerability for disruption of the fetal brain with its ongoing neurodevelopment, resulting in lifelong consequences that can enhance risk for psychiatric disorders. Cannabis and cigarettes are the most commonly used illicit and licit substances, respectively, among pregnant women.

Author(s): 
Morris, Claudia V.
DiNieri, Jennifer A.
Szutorisz, Henrietta
Hurd, Yasmin L.
Publication Title: 
Molecular Pharmacology

Immune-mediated liver diseases including autoimmune and viral hepatitis are a major health problem worldwide. Natural cannabinoids such as Delta(9)-tetrahydrocannabinol (THC) effectively modulate immune cell function, and they have shown therapeutic potential in treating inflammatory diseases. We investigated the effects of THC in a murine model of concanavalin A (ConA)-induced hepatitis. Intraperitoneal administration of THC after ConA challenge inhibited hepatitis as shown by significant decrease in liver enzymes and reduced liver tissue injury.

Author(s): 
Hegde, Venkatesh L.
Hegde, Shweta
Cravatt, Benjamin F.
Hofseth, Lorne J.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Publication Title: 
Pharmacological Research: The Official Journal of the Italian Pharmacological Society

Cannabinoid pharmacology has made important advances in recent years after the discovery of the cannabinoid receptors. These discoveries have added to our understanding of exogenous and endogenous cannabinoid signaling along with exploring the various pathways of their biosynthesis, molecular structure, inactivation, and anatomical distribution of their receptors throughout the body. The endocannabinoid system is involved in immunoregulation and neuroprotection.

Author(s): 
Pandey, Rupal
Mousawy, Khalida
Nagarkatti, Mitzi
Nagarkatti, Prakash
Publication Title: 
Vitamins and Hormones

Autoimmune hepatitis is a severe immune mediated chronic liver disease with a prevalence range between 50 and 200 cases per million in Western Europe and North America and mortality rates of up to 80% in untreated patients. The induction of CB1 and CB2 cannabinoid receptors during liver injury and the potential involvement of endocannabinoids in the regulation of this process have sparked significant interest in further evaluating the role of cannabinoid systems during hepatic disease. Cannabinoids have been shown to possess significant immunosuppressive and anti-inflammatory properties.

Author(s): 
Pandey, Rupal
Hegde, Venkatesh L.
Singh, Narendra P.
Hofseth, Lorne
Singh, Uday
Ray, Swapan
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Publication Title: 
Trends in Pharmacological Sciences

Cannabinoids have emerged as powerful drug candidates for the treatment of inflammatory and autoimmune diseases due to their immunosuppressive properties. Significant clinical and experimental data on the use of cannabinoids as anti-inflammatory agents exist in many autoimmune disease settings, but virtually no studies have been undertaken on their potential role in transplant rejection. Here we suggest a theoretical role for the use of cannabinoids in preventing allograft rejection.

Author(s): 
Nagarkatti, Mitzi
Rieder, Sadiye Amcaoglu
Hegde, Venkatesh L.
Kanada, Shunsuke
Nagarkatti, Prakash
Publication Title: 
American Journal of Therapeutics

For thousands of years, physicians and their patients employed cannabis as a therapeutic agent. Despite this extensive historical usage, in the Western world, cannabis fell into disfavor among medical professionals because the technology available in the 1800s and early 1900s did not permit reliable, standardized preparations to be developed.

Author(s): 
McCarberg, Bill H.
Barkin, Robert L.
Publication Title: 
Lipids in Health and Disease

BACKGROUND: Alterations of endocannabinoid system in adipose tissue play an important role in lipid regulation and metabolic dysfunction associated with obesity. The purpose of this study was to determine whether gene expression levels of cannabinoid type 1 receptor (CB1) and fatty acid amide hydrolase (FAAH) are different in subcutaneous abdominal and gluteal adipose tissue, and whether hypocaloric diet and aerobic exercise influence subcutaneous adipose tissue CB1 and FAAH gene expression in obese women.

Author(s): 
You, Tongjian
Disanzo, Beth L.
Wang, Xuewen
Yang, Rongze
Gong, Dawei
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