Capsaicin

Publication Title: 
Rheumatology (Oxford, England)

OBJECTIVE: To critically evaluate the evidence regarding complementary and alternative medicines (CAMs) taken orally or applied topically for the treatment of FM. METHODS: Randomized controlled trials of FM using CAMs, in comparison with other treatments or placebo, published in English up to March 2009, were eligible for inclusion. They were identified using systematic searches of bibliographic databases and manual searching of reference lists.

Author(s): 
De Silva, Vijitha
El-Metwally, Ashraf
Ernst, Edzard
Lewith, George
Macfarlane, Gary J.
Arthritis Research Campaign working group on complementary and alternative medicines
Publication Title: 
American Family Physician

Knee osteoarthritis is a common disabling condition that affects more than one-third of persons older than 65 years. Exercise, weight loss, physical therapy, intra-articular corticosteroid injections, and the use of nonsteroidal anti-inflammatory drugs and braces or heel wedges decrease pain and improve function. Acetaminophen, glucosamine, ginger, S-adenosylmethionine (SAM-e), capsaicin cream, topical nonsteroidal anti-inflammatory drugs, acupuncture, and tai chi may offer some benefit. Tramadol has a poor trade-off between risks and benefits and is not routinely recommended.

Author(s): 
Ringdahl, Erika
Pandit, Sandesh
Publication Title: 
The Journal of Pain: Official Journal of the American Pain Society

The clinical pattern of neuropathic pain, diagnosed using the quantitative sensory testing (QST) battery (German Research Network on Neuropathic Pain), could be partly mimicked in healthy volunteers after topical capsaicin application. However, similar to clinical neuropathic pain that develops in only a subgroup of patients who have a neurologic lesion, this attempt to mimick a neuropathic pain pattern succeeded only in a small fraction (18%) of healthy individuals.

Author(s): 
Dimova, Violeta
Oertel, Bruno G.
Kabakci, G¸lden
Zimmermann, Michael
Hermens, Hanneke
Lautenbacher, Stefan
Ultsch, Alfred
Lˆtsch, Jˆrn
Publication Title: 
Cell

Traditional medicines provide fertile ground for modern drug development, but first they must pass along a pathway of discovery, isolation, and mechanistic studies before eventual deployment in the clinic. Here, we highlight the challenges along this route, focusing on the compounds artemisinin, triptolide, celastrol, capsaicin, and curcumin.

Author(s): 
Corson, Timothy W.
Crews, Craig M.
Publication Title: 
Mediators of Inflammation

Many diseases have been described to be associated with inflammatory processes. The currently available anti-inflammatory drug therapy is often not successful or causes intolerable side effects. Thus, new anti-inflammatory substances are still urgently needed. Plants were the first source of remedies in the history of mankind. Since their chemical characterization in the 19th century, herbal bioactive compounds have fueled drug development. Also, nowadays, new plant-derived agents continuously enrich our drug arsenal (e.g., vincristine, galantamine, and artemisinin).

Author(s): 
Fürst, Robert
Zündorf, Ilse
Publication Title: 
International Review of Neurobiology

Despite the increasing use of aromatherapy oils, there have not been many studies exploring the biological activities of bergamot (Citrus bergamia, Risso) essential oil (BEO). Recently, we have investigated the effects of BEO injected into the plantar surface of the hindpaw in the capsaicin test in mice. The intraplantar injection of capsaicin produced an intense and short-lived licking/biting response toward the injected hindpaw. The capsaicin-induced nociceptive response was reduced significantly by intraplantar injection of BEO.

Author(s): 
Sakurada, Tsukasa
Kuwahata, Hikari
Katsuyama, Soh
Komatsu, Takaaki
Morrone, Luigi Antonio
Corasaniti, Maria Tiziana
Bagetta, Giacinto
Sakurada, Shinobu
Publication Title: 
Frontiers in Bioscience: A Journal and Virtual Library

The use of complementary and alternative medicine (CAM) is increasing rapidly in developed countries, which is already in use as traditional medicines in various Asian countries. The Indian system of medicine, named as Ayurveda has an edge in this field. Many plant products are in use as herbal medicine, as food supplement or as spices, in every day cooking. Some of them have been well studied in various experimental models of cancer, both in vivo and in vitro models. They have shown significant inhibition of cell proliferation.

Author(s): 
Tripathi, Yamini B.
Tripathi, Pratibha
Arjmandi, Behram H.
Publication Title: 
Frontiers in Bioscience: A Journal and Virtual Library

The use of complementary and alternative medicine (CAM) is increasing rapidly in developed countries, which is already in use as traditional medicines in various Asian countries. The Indian system of medicine, named as Ayurveda has an edge in this field. Many plant products are in use as herbal medicine, as food supplement or as spices, in every day cooking. Some of them have been well studied in various experimental models of cancer, both in vivo and in vitro models. They have shown significant inhibition of cell proliferation.

Author(s): 
Tripathi, Yamini B.
Tripathi, Pratibha
Arjmandi, Behram H.
Publication Title: 
Pain

This study tests the hypothesis that central sensitization initiated by nociceptive input can be maintained by repeated brief innocuous peripheral inputs. Capsaicin was injected intradermally into the hind paw of adult rats. Three different types of daily cutaneous mechanical stimulations (vibration, soft brush, or pressure) were applied to the capsaicin-injected paw for a period of 2 weeks. Daily stimulation consisted of a 10-s stimulation repeated every 30s for 30 min. Foot withdrawal thresholds to von Frey stimuli applied to the paw were measured once a day for 4 weeks.

Author(s): 
Kim, Hee Kee
Schattschneider, Jörn
Lee, Inhyung
Chung, Kyungsoon
Baron, Ralf
Chung, Jin Mo
Publication Title: 
Pain

Recent studies indicate that reactive oxygen species (ROS) play an important role in neuropathic pain, predominantly through spinal mechanisms. Since the data suggest that ROS are involved in central sensitization, the present study examines the levels of activated N-methyl-d-aspartate (NMDA) receptors in the dorsal horn before and after removal of ROS with a ROS scavenger, phenyl-N-t-butyl nitrone (PBN), in animal models of pain. Tight ligation of the L5 spinal nerve was used for the neuropathic pain model and intradermal injection of capsaicin was used for the inflammatory pain model.

Author(s): 
Gao, Xiu
Kim, Hee Kee
Chung, Jin Mo
Chung, Kyungsoon

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