Carbamazepine

Publication Title: 
Alternative Therapies in Health and Medicine

BACKGROUND: Trigeminal neuralgia (TN) is a commonly seen pain condition with limited treatments available, and acupuncture is widely used for pain conditions, including TN. OBJECTIVES: To review the efficacy of acupuncture treatment for TN. METHODS: English and Chinese databases were searched extensively to identify randomized controlled studies of acupuncture treatment for TN. Selected studies were assessed for methodological quality. Odds ratios (OR) between treatment and control groups were used to assess efficacy.

Author(s): 
Liu, Hua
Li, Hong
Xu, Min
Chung, Ka-Fai
Zhang, Shi Ping
Publication Title: 
The International Journal of Neuropsychopharmacology

Unraveling the epigenetic status of neuronal cells in the brain is critical to our understanding of the pathophysiology of psychiatric disorders, which may reflect a complex interaction between genetic and environmental factors. Several epigenetic studies of mood disorders have been conducted with postmortem brains. However, proper interpretation of the results is hampered by our scant understanding of the effects of mood stabilizers on the epigenetic status of neuronal cells.

Author(s): 
Asai, Tatsuro
Bundo, Miki
Sugawara, Hiroko
Sunaga, Fumiko
Ueda, Junko
Tanaka, Gen
Ishigooka, Jun
Kasai, Kiyoto
Kato, Tadafumi
Iwamoto, Kazuya
Publication Title: 
Stem Cell Reports

Induced pluripotent stem cells (iPSCs) provide an inexhaustible source of cells for modeling disease and testing drugs. Here we develop a bioinformatic approach to detect differences between the genomic programs of iPSCs derived from diseased versus normal human cohorts as they emerge during in†vitro directed differentiation. Using iPSCs generated from a cohort carrying mutations (PiZZ) in the gene responsible for alpha-1 antitrypsin (AAT) deficiency, we find that the global transcriptomes of PiZZ iPSCs diverge from normal controls upon differentiation to hepatic cells.

Author(s): 
Wilson, Andrew A.
Ying, Lei
Liesa, Marc
Segeritz, Charis-Patricia
Mills, Jason A.
Shen, Steven S.
Jean, Jyhchang
Lonza, Geordie C.
Liberti, Derek C.
Lang, Alex H.
Nazaire, Jean
Gower, Adam C.
M¸eller, Franz-Josef
Mehta, Pankaj
OrdÛÒez, Adriana
Lomas, David A.
Vallier, Ludovic
Murphy, George J.
Mostoslavsky, Gustavo
Spira, Avrum
Shirihai, Orian S.
Ramirez, Maria I.
Gadue, Paul
Kotton, Darrell N.
Publication Title: 
Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology

Compounds with anti-glutamatergic properties currently in clinical use for various indications (eg Alzheimer's disease, epilepsy, psychosis, mood disorders) have potential utility as novel treatments for alcoholism. Enhanced sensitivity to certain acute intoxicating effects (ataxia, sedative) of alcohol may be one mechanism by which anti-glutamatergic drugs modulate alcohol use.

Author(s): 
Chen, Yi-Chyan
Holmes, Andrew
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Although activation of CYP3A4 is frequently observed in vitro, predictive computational-based models and methods for in vitro-in vivo scaling are scarce. It has been previously shown that in vitro CYP3A4 heteroactivation of carbamazepine (CBZ)-epoxide (ep) formation can be associated with the clinical drug interaction between felbatame and CBZ. The previously reported prediction methodology is applied here to an additional set of in vitro CYP3A4 heteroactivators, some exerting this effect at concentrations relevant in vivo.

Author(s): 
Egnell, Ann-Charlotte
Houston, J. Brian
Boyer, C. Scott
Publication Title: 
PloS One

Bacopa monniera is a traditional Ayurvedic herbal medicine used to treat various mental ailments from ancient times. Recently, chemically standardized alcoholic extract of Bacopa monniera (BM) has been developed and currently available as over the counter herbal remedy for memory enhancement in children and adults. However, the consumption of herbal drugs has been reported to alter the expression of drug metabolizing enzymes and membrane transporters.

Author(s): 
Singh, Rajbir
Panduri, Jagadeesh
Kumar, Devendra
Kumar, Deepak
Chandsana, Hardik
Ramakrishna, Rachumallu
Bhatta, Rabi Sankar
Publication Title: 
PloS One

Bacopa monniera is a traditional Ayurvedic herbal medicine used to treat various mental ailments from ancient times. Recently, chemically standardized alcoholic extract of Bacopa monniera (BM) has been developed and currently available as over the counter herbal remedy for memory enhancement in children and adults. However, the consumption of herbal drugs has been reported to alter the expression of drug metabolizing enzymes and membrane transporters.

Author(s): 
Singh, Rajbir
Panduri, Jagadeesh
Kumar, Devendra
Kumar, Deepak
Chandsana, Hardik
Ramakrishna, Rachumallu
Bhatta, Rabi Sankar
Publication Title: 
Compendium of Continuing Education in Dentistry (Jamesburg, N.J.: 1995)

The purpose of this article is to give a concise review of the diagnosis and management of trigeminal neuralgia (TN), with particular emphasis on idiopathic TN and symptomatic TN. The clinical characteristics of both conditions are presented, and the suspected underlying etiologies are discussed. Because it is crucial for clinicians to be able to rule out pain unrelated to TN, a list of differential diagnoses is presented. The authors stress that the diagnosis of TN is made clinically; however, diagnostic imaging may be indicated in selected cases.

Author(s): 
Türp, J. C.
Gobetti, J. P.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

OBJECTIVE: To discuss a case of trigeminal neuralgia that responded to an accidental high-intensity discharge of electrical current delivered by a transcutaneous electrical nerve stimulator (TENS). CLINICAL FEATURES: A 36-yr-old man suffering from a 5-month history of worsening paroxysmal pain of the left facial and temporal regions was referred to a neurologist by his family physician. A clinical diagnosis of trigeminal neuralgia was made; before committing to pharmaceutical treatment, however, the patient sought chiropractic consultation.

Author(s): 
Thorsen, S. W.
Lumsden, S. G.
Publication Title: 
Biological & Pharmaceutical Bulletin

The present study was conducted to evaluate the effects of Paeoniae Radix (PR), one of the most famous tonic traditional Chinese medicines, on the pharmacokinetics of carbamazepine (CBZ) in rats and to determine the possible interactions between PR and CBZ. The significant decrease in Tmax indicated that simultaneous oral administration of PR contributed to more rapid absorption of CBZ. It is suggested that the faster absorption of CBZ might lead to the rapid onset of its clinical effect.

Author(s): 
Chen, Lih-Chi
Chen, Yu-Fang
Chou, Mei-Huei
Lin, Ming-Fang
Yang, Ling-Ling
Yen, Kun-Ying

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