Carbon Dioxide

Publication Title: 
Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials

The fatty oils in Terminulia chebula were extracted by supercritical-CO2 fluid extraetion, and their fatty acids and its relative contents were determined by GC-MS. 12 fatty acids were identified. Palmitic acid, linoleic acid and oleic acid of them are main constituents. Compared with petroleum ether extraction method, the extraction rate from SFE-CO2 is higher and extraction time shorter.

Author(s): 
Zhang, X.
Chen, C.
He, S.
Ge, F.
Publication Title: 
Nature

The naked mole rat (Heterocephalus glaber) is a strictly subterranean, extraordinarily long-lived eusocial mammal. Although it is the size of a mouse, its maximum lifespan exceeds 30 years, making this animal the longest-living rodent. Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. In addition to delayed ageing, they are resistant to both spontaneous cancer and experimentally induced tumorigenesis. Naked mole rats pose a challenge to the theories that link ageing, cancer and redox homeostasis.

Author(s): 
Kim, Eun Bae
Fang, Xiaodong
Fushan, Alexey A.
Huang, Zhiyong
Lobanov, Alexei V.
Han, Lijuan
Marino, Stefano M.
Sun, Xiaoqing
Turanov, Anton A.
Yang, Pengcheng
Yim, Sun Hee
Zhao, Xiang
Kasaikina, Marina V.
Stoletzki, Nina
Peng, Chunfang
Polak, Paz
Xiong, Zhiqiang
Kiezun, Adam
Zhu, Yabing
Chen, Yuanxin
Kryukov, Gregory V.
Zhang, Qiang
Peshkin, Leonid
Yang, Lan
Bronson, Roderick T.
Buffenstein, Rochelle
Wang, Bo
Han, Changlei
Li, Qiye
Chen, Li
Zhao, Wei
Sunyaev, Shamil R.
Park, Thomas J.
Zhang, Guojie
Wang, Jun
Gladyshev, Vadim N.
Publication Title: 
The EMBO journal

Lifespan of C. elegans is affected by the nervous system; however, the underlying neural integration still remains unclear. In this work, we targeted an antagonistic neural system consisting of low-oxygen sensing BAG neurons and high-oxygen sensing URX neurons. While ablation of BAG neurons increases lifespan of C. elegans, ablation of URX neurons decreases lifespan. Genetic analysis revealed that BAG and URX neurons counterbalance each other via different guanylate cyclases (GCYs) to control lifespan balance.

Author(s): 
Liu, Tiewen
Cai, Dongsheng
Publication Title: 
Psychosomatic Medicine
Author(s): 
Dudley, D. L.
Holmes, T. H.
Martin, C. J.
Ripley, H. S.
Publication Title: 
The British Journal of Medical Psychology
Author(s): 
Polites, D. J.
Kruger, D.
Stevenson, I.
Publication Title: 
Annals of the New York Academy of Sciences
Author(s): 
Seriff, N. S.
Publication Title: 
JAMA
Author(s): 
Katz, J.
Publication Title: 
British Journal of Hospital Medicine
Author(s): 
Maher-Loughman, G. P.
Publication Title: 
Der Anaesthesist

Sufentanil, a synthetic opioid that is 5-10 times as potent as fentanyl, has been suggested for use during neurosurgical procedures because it maintains cardiovascular stability and produces hypnosis without the use of additional anesthetic agents. Doses as low as 2.5 micrograms.kg-1 are reported to create deep levels of anesthesia as demonstrated by EEG changes to high-amplitude delta-waves. However, there are no reports concerning the effects of sufentanil on blood flow and metabolism in the human brain.

Author(s): 
Stephan, H.
Gröger, P.
Weyland, A.
Hoeft, A.
Sonntag, H.
Publication Title: 
Anesthesiology

BACKGROUND: In humans the ventilatory response to isocapnic hypoxia is biphasic: an initial increase in minute ventilation (VE) from baseline, the acute hypoxic response, is followed after 3-5 min by a slow ventilatory decay, the hypoxic ventilatory decline, and a new steady state, 25-40% greater than baseline VE, is reached in about 15-20 min. The transition from 20 min of isocapnic hypoxia into normoxia results in a rapid decrease in VE, the off-response. In humans, halothane, at subanesthetic concentrations, is known to decrease the acute hypoxic response.

Author(s): 
Dahan, A.
van den Elsen, M. J.
Berkenbosch, A.
DeGoede, J.
Olievier, I. C.
Burm, A. G.
van Kleef, J. W.

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