Carcinoma, Non-Small-Cell Lung

Publication Title: 
Voprosy Onkologii

There is a considerable variation in individual lifespan among cancer patients with identical diagnosis. We used damped exponential approximation, which includes both single- and double-compartment extension, for radiobiological assessment of survival curves among cases of breast, lung and oro-pharyngeal cancer. It was shown that in certain cases (breast--T2N1-2M0T3N1-2M0 and oro-pharyngeal cancer--T2-4N1-3M0) the curves can be identified with the two compartments which in turn are associated with different rates of mortality.

Author(s): 
Bochkareva, T. N.
Ekimova, L. P.
Nemkova, E. V.
Sokurenko, V. P.
Shutko, A. N.
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To our knowledge, there has been no clinical report of artesunate in the treatment of lung cancer. This study was designed to compare the efficacy and toxicity of artesunate combined with NP (a chemotherapy regimen of vinorelbine and cisplatin) and NP alone in the treatment of advanced non-small cell lung cancer (NSCLC). METHODS: One hundred and twenty cases of advanced NSCLC were randomly divided into simple chemotherapy group (control group, n=60) and combined artesunare with chemotherapy group (trial group, n=60).

Author(s): 
Zhang, Zhu-Yi
Yu, Shi-Qing
Miao, Li-Yun
Huang, Xiao-Ying
Zhang, Xiao-ping
Zhu, Yu-Ping
Xia, Xiao-hong
Li, Dan-Qi
Publication Title: 
Molecules (Basel, Switzerland)

Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. Clinical and laboratory studies have suggested that multi-targeting approaches against neoplastic cells could help to increase patient survival and might reduce the emergence of cells that are resistant to single-target inhibitors. Artesunate (ART) is one of the most potent and rapidly acting antimalarial agents known, and it also exerts a profound cytotoxic activity toward cancer cells and reverses multi-drug resistance.

Author(s): 
Ma, Hu
Yao, Quan
Zhang, An-Mei
Lin, Sheng
Wang, Xin-Xin
Wu, Lei
Sun, Jian-Guo
Chen, Zheng-Tang
Publication Title: 
Journal of Complementary & Integrative Medicine

Although lung cancer is perceived as a dire diagnosis, increases in the 5-year survival rate of individuals with non-small cell lung cancer (NSCLC) have been reported. Survivors, however, continue to be excessively burdened with symptoms such as respiratory distress which interfere with functioning and quality of life.

Author(s): 
M Fouladbakhsh, Judith
Davis, Jean E.
Yarandi, Hossein N.
Publication Title: 
Oncology Nursing Forum

PURPOSE/OBJECTIVES: To examine the effects of spirituality on the sense of well-being of people with lung cancer. DESIGN: Descriptive, correlational study. SETTING: Urban and rural oncology and radiation centers. SAMPLE: 60 adults ranging from 33-83 years of age. Most participants had non-small cell lung cancer and were female, Caucasian, and older than 50.

Author(s): 
Meraviglia, Martha Gene
Publication Title: 
Thoracic Surgery Clinics

Patients express risk aversion toward surgery, particularly if surgery can lead to lifelong debility and loss of independence. When faced with a guarantee of progressive lung cancer and no alternatives for cure, however, patients are willing to take extremely high risks of postoperative complications and surgery-related death. This result occurs because risk aversion toward unrelenting cancer death supersedes patients' risk attitudes toward almost all other health states.

Author(s): 
Cykert, Samuel
Publication Title: 
Oncology Nursing Forum

PURPOSE/OBJECTIVES: To examine the effects of spirituality on the sense of well-being of people with lung cancer. DESIGN: Descriptive, correlational study. SETTING: Urban and rural oncology and radiation centers. SAMPLE: 60 adults ranging from 33-83 years of age. Most participants had non-small cell lung cancer and were female, Caucasian, and older than 50.

Author(s): 
Meraviglia, Martha Gene
Publication Title: 
Thoracic Surgery Clinics

Patients express risk aversion toward surgery, particularly if surgery can lead to lifelong debility and loss of independence. When faced with a guarantee of progressive lung cancer and no alternatives for cure, however, patients are willing to take extremely high risks of postoperative complications and surgery-related death. This result occurs because risk aversion toward unrelenting cancer death supersedes patients' risk attitudes toward almost all other health states.

Author(s): 
Cykert, Samuel
Publication Title: 
Cancer Nursing

Complementary and alternative medicine (CAM) use by cancer patients, especially women, is increasing. However, CAM use among patients with lung cancer, who have been reported to have the highest symptom burden, is poorly documented. This study describes types and frequencies of specific CAM therapies used by women with lung cancer to manage symptoms, and examines differences in demographic and clinical characteristics between CAM users and non-CAM users. Participants included 189 women with non-small cell lung cancer and > or =1 of 8 symptoms.

Author(s): 
Wells, Marjorie
Sarna, Linda
Cooley, Mary E.
Brown, Jean K.
Chernecky, Cynthia
Williams, Roma D.
Padilla, Geraldine
Danao, Leda Layo
Publication Title: 
Experimental Oncology

AIM: To investigate the anti-proliferative effects of Crocus sativus extract and its major constituent, crocin, on three colorectal cancer cell lines (HCT-116, SW-480, and HT-29). The cell growth inhibition effect was compared to that of non-small cell lung cancer (NSCLC) cells. In addition, Crocus sativus' effect on non-cancer cells was evaluated. METHODS: Using high performance liquid chromatography (HPLC), the purity of crocin and the content of crocin extract were determined. Anti-proliferative effects of Crocus sativus extract and crocin on test cells was evaluated by MTS assay.

Author(s): 
Aung, H. H.
Wang, C. Z.
Ni, M.
Fishbein, A.
Mehendale, S. R.
Xie, J. T.
Shoyama, C. Y.
Yuan, C. S.

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