Cardiovascular System

Publication Title: 
Folia Biologica

Positive evolutionary pressure has apparently preserved the ability to synthesize chemically authentic morphine, albeit in homeopathic concentrations, throughout animal phyla.

Stefano, G. B.
Ptá?ek, R.
Kuželová, H.
Kream, R. M.
Publication Title: 
Cardiovascular Diabetology

Diabetes mellitus currently affects more than 170 million individuals worldwide and is expected to afflict another 200 million individuals in the next 30?years. Complications of diabetes as a result of oxidant stress affect multiple systems throughout the body, but involvement of the cardiovascular system may be one of the most severe in light of the impact upon cardiac and vascular function that can result in rapid morbidity and mortality for individuals.

Chong, Zhao Zhong
Maiese, Kenneth
Publication Title: 
Experimental Gerontology
Everitt, A. V.
Publication Title: 
Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association

The French paradox is a dietary anomaly which has focused attention on the Mediterranean diet. Epidemiological studies revealed that this diet, replete in flavonoid-rich foods (Allium and Brassica vegetables, and red wine), correlated with the increased longevity and decreased incidence of cardiovascular disease seen in these populations. The most frequently studied flavonoid, quercetin, has been shown to have biological properties consistent with its sparing effect on the cardiovascular system.

Formica, J. V.
Regelson, W.
Publication Title: 

The mechanisms for cellular aging have yet to be elucidated, but most data are in favor of a combination of processes. Such theories include a neuroendocrine group of theories, an immunological theory, the theory with a limited number of cell divisions as a basis, and the "wear-and-tear" theories together with e.g. oxidative stress and DNA damage. New data on cardiac aging have implications for geriatric medicine.

Steen, B.
Publication Title: 

Obesity promotes the development of several major cardiovascular risk factors. Moreover, excess adiposity may play a direct role in initiating atherosclerosis as fat cells are capable of affecting the systemic vasculature through a variety of mechanisms. Recent studies demonstrate that obesity per se may impair vascular endothelial function. This is important as endothelial dysfunction is a key factor in the pathogenesis of atherosclerosis and in triggering acute ischemic events.

Brook, Robert D.
Publication Title: 
Nutrition Journal

BACKGROUND: One of the major challenges associated with our ageing population is the increasing incidence of age-associated cognitive decline, which has significant implications for an individual's ability to lead a productive and fulfilling life. In pure economic terms the costs of ageing reflects decreased productivity and engagement with the workforce. The maintenance of brain health underpinning intact cognition is a key factor to maintaining a positive, engaged, and productive lifestyle.

Stough, Con K.
Pase, Matthew P.
Cropley, Vanessa
Myers, Stephen
Nolidin, Karen
King, Rebecca
Camfield, David
Wesnes, Keith
Pipingas, Andrew
Croft, Kevin
Chang, Dennis
Scholey, Andrew B.
Publication Title: 
Minerva Medica
Valerio de Carli, J.
Publication Title: 
Anaesthesia, Resuscitation, and Intensive Therapy

Flunitrazepam, a derivative of benzodiazepine was used for induction and maintenance of anaesthesia in 933 patients. The induction dose was from 1,786 to 2,053 mg. The total dose of 2-2.66 mg was sufficient for maintenance of hypnosis for about 2 hours. The undesirable side effects were very rare. The average time of hypnosis after a single dose of flunitrazepam was 50.1 sec. The sedative action of the drug lasted for some time after regaining of consciousness. In most patients there was no need for administration of analgetics during first 24 hours after the operation.

Rizzi, R.
Butera, G.
Lion, P.
Pesarin, F.
Publication Title: 
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica

In the central nervous system, ZM decreased locomotor activity and potentiated hypnosis of hexobarbital-Na in mice. ZM had little hypothermic action and there were no anticonvulsive effects on chemoconvulsion and electroconvulsion shock. ZM, 3 mg/kg i.v. produced a sleep-like pattern in the spontaneous EEG activity of cat; from 20 to 30 min. after injection, spindle burst-like waves (12-13 Hz) appeared in the cortex and subcortex. These EEG activities were antagonized by atropine sulfate.

Suzuki, Y.
Kajiyama, K.
Taguchi, K.
Hagiwara, Y.
Imada, Y.


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