Carrageenan

Publication Title: 
Journal of Traditional and Complementary Medicine

The present study was carried out to evaluate in vivo and in vitro anti-inflammatory potential of selected medicinal plants used in Indian traditional medication. The sequentially extracted plant samples as, Cissus quadrangularis, Plumbago zeylanica, Terminalia bellarica and Terminalia chebula in water, ethanol and hexane were evaluated in-vitro for COX-1 and 2 inhibitory and antioxidant activities. The in vivo anti-inflammatory activity of selected samples showing promising COX-2 inhibition was assessed using carrageenan and Phorbol Myristate Acetate (PMA) induced mice edema animal model.

Author(s): 
Shaikh, Rafik U.
Pund, Mahesh M.
Gacche, Rajesh N.
Publication Title: 
Research Communications in Chemical Pathology and Pharmacology

Twenty-four hours after treatment with carrageenan the duration of hexobarbital-induced hypnosis was prolonged in males but not females in Wistar rats bearing carrageenan-induced paw edema. Similar treatment with carrageenan led to significant inhibition of the metabolism of hexobarbital by hepatic enzymes obtained from male but not female animals. These data suggest that there is a sex-related difference in the ability of carrageenan to alter drug actions in rats.

Author(s): 
Ishikawa, M.
Sasaki, K.
Ozaki, M.
Takayanagi, Y.
Sasaki, K.
Publication Title: 
Research Communications in Chemical Pathology and Pharmacology

In male rats bearing carrageenan-induced paw edema twenty-four hours after treatment with carrageenan the duration of hexobarbital hypnosis was prolonged and the rate of hepatic hexobarbital metabolism was inhibited. By contrast, treatment with carrageenan potentiates zoxazolamine paralysis time and inhibits zoxazolamine metabolism in both male and female rats. Thus, sex-related differences in the rats bearing carrageenan-induced paw edema and inhibition of drug metabolism are apparently substrate dependent.

Author(s): 
Ishikawa, M.
Sasaki, K.
Yakayanagi, Y.
Sasaki, K.
Publication Title: 
Journal of Pharmacobio-Dynamics

Following in vivo treatment with carrageenan, sex-related differences in alteration of hepatic drug metabolism were found in the rat. In adult male rats, marked decreases were observed in hepatic 9000 x g supernatant cytochrome P-450 content and in the biotransformation of hexobarbital, aminopyrine, ethylmorphine, and meperidine. Hexobarbital hypnosis was significantly prolonged by carrageenan treatment in intact and testectomized animals as compared to their respective controls.

Author(s): 
Ishikawa, M.
Sasaki, K.
Ozaki, M.
Takayanagi, Y.
Sasaki, K.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Artemisia annua L. has been used for many centuries in Chinese traditional medicine. Artemisinin, the active principle was first isolated and identified in the 1970s becoming the global back bone to the fight against malaria. Our research group previously developed an economic and ecological friendly process to obtain this compound. In the pursuit to also exploit the residue generated throughout the process we further evaluated the pharmacological potential of that extract.

Author(s): 
Favero, Fabricio de Faveri
Grando, Rogério
Nonato, Fabiana R.
Sousa, Ilza M. M.
Queiroz, Núbia C. A.
Longato, Giovanna B.
Zafred, Rafael R. T.
Carvalho, João E.
Spindola, Humberto M.
Foglio, Mary A.
Publication Title: 
Journal of Agricultural and Food Chemistry

Isolation conditions of immunoglobulin in egg yolk (IgY) were optimized by the addition of various levels of Na-alginate (Alg), lambda-carrageenan (lambda-Cg), Na-carboxymethyl cellulose (CMC), and pectin (PC) to 6-fold diluted yolk. The mixtures were then reacted at pH 4.0-6.0 for 30 min. The optimal isolation conditions of IgY for Alg, lambda-Cg, and CMC were at the 0.1% level and at pH 5.0, while those for PC were at the 0.15% level and at the same pH.

Author(s): 
Chang, H. M.
Lu, T. C.
Chen, C. C.
Tu, Y. Y.
Hwang, J. Y.
Publication Title: 
Mediators of Inflammation

To obtain experimental evidence on the therapeutic efficacy of essential oils in aromatherapy for inflammatory diseases, we examined the effects of geranium oil on carrageenan-induced and collagen II-induced inflammation in mice, to assess acute and chronic anti-inflammatory activities of the oil. Single intraperitoneal injection of 5 mu L of geranium oil clearly suppressed the carrageenan-induced footpaw edema and increase in tissue myeloperoxidase activity, and repeated administration of the oil suppressed collagen-induced arthritis.

Author(s): 
Maruyama, Naho
Ishibashi, Hiroko
Hu, Weimin
Morofuji, Shinichiro
Inouye, Shigeharu
Yamaguchi, Hideyo
Abe, Shigeru
Publication Title: 
Acta Poloniae Pharmaceutica

The seeds of Alangium salvifolium Linn. have been traditionally reported to exhibit a variety of biological activities, including antidiabetic, anticancer, diuretic, anti-inflammatory, antimicrobial, laxative, and antiepileptic activities. The objective of this study was to verify the traditional claims and to evaluate the seeds of Alangium salvifolium in various organic extracts to screen the antidiabetic, antiepileptic, analgesic and antiinflammatory activities.

Author(s): 
Sharma, Ashish Kumar
Agarwal, Vipin
Kumar, Rajesh
Balasubramaniam, Arumugam
Mishra, Anurag
Gupta, Rajiv
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The polyherbal eye drop (Itone™) is a mixture of aqueous distillates of nineteen traditionally used ingredients that sum up to impart potency to the formulation and make it a useful adjunct in various ocular pathologies. However, as there have been no controlled experimental studies accounting to the above claim, therefore, the present study was designed to evaluate the polyherbal formulation (PHF) for antiangiogenic, anti-inflammatory, anticataract, antioxidant and cytotoxicity in addition to the evaluation of intraocular penetration of PHF in rabbit eyes using LC-MS/MS.

Author(s): 
Velpandian, Thirumurthy
Gupta, Pankaj
Ravi, Alok Kumar
Sharma, Hanuman Prasad
Biswas, Nihar Ranjan
Publication Title: 
Journal of Ethnopharmacology

Nyctanthes arbor tristis Linn. (Harsingar) is widely used as a decoction in the Ayurvedic system of medicine for treatment of sciatica and arthritis, but it has not yet been screened scientifically. In the present study, the water soluble portion of the alcoholic extract of the leaves of Nyctanthes arbor tristis (NAT) was screened for the presence of anti-inflammatory activity. NAT inhibited the acute inflammatory oedema produced by different phlogistic agents, viz. carrageenin, formalin, histamine, 5-hydroxytryptamine and hyaluronidase in the hindpaw of rats.

Author(s): 
Saxena, R. S.
Gupta, B.
Saxena, K. K.
Singh, R. C.
Prasad, D. N.

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