Caspase 3

Publication Title: 
Molecules (Basel, Switzerland)

Cichorium endivia. L, consumed either cooked or eaten raw in salads, is a popular kind of vegetable cultivated all around the World. Its components have been widely used in folk medicine in anti-inflammatory therapy. However, the anti-cancer activity of the components has never been reported. In this study, (3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (1), an amino acid isolated from C. endivia. L, was found for the first time to show cytotoxic activity in colorectal cancer cell line HCT-8.

Wang, Fu-Xin
Deng, An-Jun
Li, Ming
Wei, Jin-Feng
Qin, Hai-lin
Wang, Ai-Ping
Publication Title: 
The Journal of Biological Chemistry

Weight control by exercise and dietary calorie restriction (DCR) has been associated with reduced cancer risk, but the underlying mechanisms are not well understood. This study was designed to compare the effects of weight loss by increasing physical activity or decreasing calorie intake on tumor promoter-induced Ras-MAPK and PI3K-Akt pathways. SENCAR mice were randomly assigned to one of the following five groups: ad libitum-fed sedentary control, ad libitum-fed exercise (AL+Exe), exercise but pair-fed at the amount as controls (PF+Exe), 20% DCR, and 20% DCR plus exercise (DCR+Exe).

Xie, Linglin
Jiang, Yu
Ouyang, Ping
Chen, Jie
Doan, Hieu
Herndon, Betty
Sylvester, Jessica E.
Zhang, Ke
Molteni, Agostino
Reichle, Marie
Zhang, Rongqing
Haub, Mark D.
Baybutt, Richard C.
Wang, Weiqun
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

Ischemic tolerance decreases with aging, and the cardioprotective effect of ischemic preconditioning (IPC) is impaired in middle-aged animals. We have demonstrated that short-term caloric restriction (CR) improves myocardial ischemic tolerance in young and old animals via the activation of adiponectin-AMP-activated protein kinase (AMPK)-mediated signaling. However, it is unknown whether prolonged CR confers cardioprotection in a similar manner.

Shinmura, Ken
Tamaki, Kayoko
Bolli, Roberto
Publication Title: 
Nutrition and Cancer

We investigated whether serum from normal weight women is less mitogenic and more apoptotic than sera from the same women in the overweight state. Sera from premenopausal women, age (mean ± SEE) 34.6 ± 0.53 years, who were randomized to caloric restriction (CR) (n = 13), CR + aerobic exercise (AE) (n = 14), or CR + resistance training (RT) (n = 20) were used to culture endometrial cancer cells.

Azrad, Maria
Chang, Pi-Ling
Gower, Barbara A.
Hunter, Gary R.
Nagy, Tim R.
Publication Title: 
PloS One

Traumatic brain injury (TBI) is a widespread cause of death and a major source of adult disability. Subsequent pathological events occurring in the brain after TBI, referred to as secondary injury, continue to damage surrounding tissue resulting in substantial neuronal loss. One of the hallmarks of the secondary injury process is microglial activation resulting in increased cytokine production.

Loncarevic-Vasiljkovic, Natasa
Pesic, Vesna
Todorovic, Smilja
Popic, Jelena
Smiljanic, Kosara
Milanovic, Desanka
Ruzdijic, Sabera
Kanazir, Selma
Publication Title: 
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research

PURPOSE: In this study, we have examined the antitumor effects of chloroform extract of Angelica sinensis (AS-C), a traditional Chinese medicine, on glioblastoma multiforme (GBM) brain tumors in vitro and in vivo. EXPERIMENTAL DESIGN: In vitro, GBM cells were treated with AS-C, and the cell proliferation, changes in distributions of cell cycle, and apoptosis were determined. In vivo, human DBTRG-05MG and rat RG2 GBM tumor cells were injected s.c. or i.c. and were treated with AS-C.

Tsai, Nu-Man
Lin, Shinn-Zong
Lee, Chau-Chin
Chen, Shee-Ping
Su, Hsuan-Chi
Chang, Wen-Liang
Harn, Horng-Jyh
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

BACKGROUND & OBJECTIVE: Oldenlandia diffusa (Bai Hua She She Cao) is one of the herbs most commonly used in traditional Chinese medicine for treating cancer. Various studies using the herb alone or in combination with other therapy plans have evidenced the effectiveness of the herb in the management of cancers of different tissue origin. However, the mechanisms underlying its anti-cancer activity are unknown. In the present study, we attempted to investigate the apoptotic activity of crude extracts of the herb as well as the possible molecular pathways.

Yadav, Sanjiv Kumar
Lee, Shao Chin
Publication Title: 
Biological & Pharmaceutical Bulletin

Triptolide, a purified diterpenoid triepoxide compound derived from a traditional Chinese medicine, Tripterygium wilfordii HOOK. f (TWHf), has been used in the treatment of autoimmune and inflammatory diseases. However, the toxicity of triptolide limits its application to a great extent. In the present study, we treated human normal liver L-02 cells (L-02 cells) with triptolide in vitro and investigated its toxic effects.

Yao, Jincheng
Jiang, Zhenzhou
Duan, Weigang
Huang, Jingfeng
Zhang, Luyong
Hu, Ling
He, Ling
Li, Fu
Xiao, Yajie
Shu, Bin
Liu, Chunhui
Publication Title: 
Acta Pharmacologica Sinica

AIM: Gambogic acid (GA) is the major active ingredient of gamboge, which is secreted from a Chinese traditional medicine, Garcinia hanburyi, which possesses potent antitumor activity. GA3, a new GA derivative, has been shown to possess better water solubility than GA. The aim of the present study was to examine the antitumor activity of GA3 and the mechanism underlying it. METHODS: The growth inhibition of cancer cell lines induced by GA3 was assessed using the SRB assay.

Xie, Hua
Qin, Yu-xin
Zhou, Yun-long
Tong, Lin-Jiang
Lin, Li-ping
Geng, Mei-yu
Duan, Wen-hu
Ding, Jian
Publication Title: 
The Journal of Sexual Medicine

INTRODUCTION: Epimedium species (aka horny goat weed) have been utilized for the treatment of erectile dysfunction in Traditional Chinese Medicine for many years. Icariin (ICA) is the active moiety of Epimedium species. AIM: To evaluate the penile hemodynamic and tissue effects of ICA in cavernous nerve injured rats. We also studied the in vitro effects of ICA on cultured pelvic ganglia. METHODS: Rats were subjected to cavernous nerve injury and subsequently treated for 4 weeks with daily gavage feedings of a placebo solution of normal saline and Dimethyl sulfoxide (DMSO) vs.

Shindel, Alan W.
Xin, Zhong-Chen
Lin, Guiting
Fandel, Thomas M.
Huang, Yun-Ching
Banie, Lia
Breyer, Benjamin N.
Garcia, Maurice M.
Lin, Ching-Shwun
Lue, Tom F.


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