CCAAT-Enhancer-Binding Protein-delta

Publication Title: 
Cancer Research

1,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the active metabolite of vitamin D3, inhibits the proliferation of prostate cancer cells. However, the molecular mechanisms by which 1,25(OH)2D3 inhibits the proliferation of these cells remain to be fully elucidated. In this study, we used microarray technology to identify target genes of 1,25(OH)2D3 in androgen-responsive prostate cancer LNCaP cells. 1,25(OH)2D3 up-regulated CCAAT/enhancer-binding protein delta (C/EBPdelta) by approximately 5-fold in these cells.

Author(s): 
Ikezoe, Takayuki
Gery, Sigal
Yin, Dong
O'Kelly, James
Binderup, Lise
Lemp, Nathan
Taguchi, Hirokuni
Koeffler, H. Phillip
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