CD4-Positive T-Lymphocytes

Publication Title: 
Chemico-Biological Interactions

Many herbs and spices are known to modulate the immune system and have been shown to restore the immunity in immuno-compromised individuals. Spices generally used to increase the taste and flavor of food also has the history of usage as an ayurvedic medicine. Therefore to explore the health modulating effects of Cuminum cyminum and to identify the active compound, immunomodulatory properties were evaluated using flowcytometry and ELISA in normal and immune-suppressed animals. C. cyminum and compound 1 stimulated the T cells and Th1 cytokines expression in normal animals.

Author(s): 
Chauhan, Prashant Singh
Satti, Naresh Kumar
Suri, Krishan Avtar
Amina, Musarat
Bani, Sarang
Publication Title: 
Phytotherapy research: PTR

Indukantha Ghritha (IG), a polyherbal drug used for centuries in Ayurveda, is claimed to be successful in the treatment of respiratory diseases and as a rejuvenating drug. To date, little is known about the immunomodulatory role of IG in recurrent upper respiratory tract infections (RURIs). This study was designed to scientifically validate and evaluate the immunological response mechanisms in patients with RURI.

Author(s): 
Radhakrishnan, Rajesh
George, Suraj K.
Kumar, Sunil
Balaram, Prabha
Publication Title: 
Journal of Psychosomatic Research

This study examines the relationship between religiosity and the affective and immune status of 106 HIV-seropositive mildly symptomatic gay men (CDC stage B). All men completed an intake interview, a set of psychosocial questionnaires, and provided a venous blood sample. Factor analysis of 12 religiously oriented response items revealed two distinct aspects to religiosity: religious coping and religious behavior.

Author(s): 
Woods, T. E.
Antoni, M. H.
Ironson, G. H.
Kling, D. W.
Publication Title: 
Carcinogenesis

Ulcerative colitis is a dynamic, chronic inflammatory condition of the colon associated with an increased colon cancer risk. Ginkgo biloba is a putative antioxidant and has been used for thousands of years to treat a variety of ailments. The aim of this study was to test whether the standardized G.biloba extract, EGb 761, is an antioxidant that can be used to prevent and treat colitis in mice. Here, we show that EGb 761 suppresses the activation of macrophages and can be used to both prevent and treat mouse colitis.

Author(s): 
Kotakadi, Venkata S.
Jin, Yu
Hofseth, Anne B.
Ying, Lei
Cui, Xiangli
Volate, Suresh
Chumanevich, Alexander
Wood, Patricia A.
Price, Robert L.
McNeal, Anna
Singh, Udai P.
Singh, Narendra P.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Matesic, Lydia E.
Auclair, Karine
Wargovich, Michael J.
Hofseth, Lorne J.
Publication Title: 
Carcinogenesis

Ulcerative colitis (UC) is a dynamic, idiopathic, chronic inflammatory condition associated with a high colon cancer risk. American ginseng has antioxidant properties and targets many of the players in inflammation. The aim of this study was to test whether American ginseng extract prevents and treats colitis. Colitis in mice was induced by the presence of 1% dextran sulfate sodium (DSS) in the drinking water or by 1% oxazolone rectally.

Author(s): 
Jin, Yu
Kotakadi, Venkata S.
Ying, Lei
Hofseth, Anne B.
Cui, Xiangli
Wood, Patricia A.
Windust, Anthony
Matesic, Lydia E.
Pena, Edsel A.
Chiuzan, Codruta
Singh, Narendra P.
Nagarkatti, Mitzi
Nagarkatti, Prakash S.
Wargovich, Michael J.
Hofseth, Lorne J.
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Specific pathogen-free IL-10 KO mice failed to develop inflammatory bowel disease (IBD), whereas IL-10/vitamin D receptor (VDR) double KO mice developed fulminating IBD. WT CD4 T cells inhibited experimental IBD, while VDR KO CD4 T cells failed to suppress IBD. VDR KO mice had normal numbers and functions of regulatory T cells. The percentages of IL-17- and IFN-gamma-secreting T cells in the gut of mice reconstituted with WT and VDR KO CD4 T cells were also not different.

Author(s): 
Yu, Sanhong
Bruce, Danny
Froicu, Monica
Weaver, Veronika
Cantorna, Margherita T.
Publication Title: 
International Immunopharmacology

Bromelain (Br), an extract from pineapple stem with cysteine protease activity, exerts anti-inflammatory effects in a number of inflammatory models. We have previously shown that Br treatment decreased activated CD4(+) T cells and has a therapeutic role in an ovalbumin-induced murine model of allergic airway disease. The current study was designed to determine the effect of Br on CD4(+) T cell activation, specifically the expression of CD25 in vitro.

Author(s): 
Secor, Eric R.
Singh, Anurag
Guernsey, Linda A.
McNamara, Jeff T.
Zhan, Lijun
Maulik, Nilanjana
Thrall, Roger S.
Publication Title: 
The Journal of Allergy and Clinical Immunology

BACKGROUND: Previously, we presented evidence that at physiologic concentrations the green tea catechin, epigallocatechin gallate (EGCG), inhibited attachment of HIV-1 glycoprotein 120 to the CD4 molecule on T cells, but the downstream effects of EGCG on HIV-1 infectivity were not determined. OBJECTIVE: To evaluate the inhibition of HIV-1 infectivity by EGCG and begin preclinical development of EGCG as a possible therapy. METHODS: PBMCs, CD4(+) T cells, and macrophages were isolated from blood of HIV-1-uninfected donors. HIV-1 infectivity was assessed by an HIV-1 p24 ELISA.

Author(s): 
Nance, Christina L.
Siwak, Edward B.
Shearer, William T.
Publication Title: 
European Journal of Clinical Pharmacology

PURPOSE: P-glycoprotein limits the tissue penetration of many antiretroviral drugs. The aim of our study was to characterize the effects of the P-glycoprotein substrate cyclosporin A on T cell P-glycoprotein activity in human immunodeficiency virus-infected participants in the AIDS Clinical Trials Group study A5138. METHODS: We studied P-glycoprotein activity on CD4 and CD8 T cells in 16 participants randomized to receive oral cyclosporin A (n=9) or not (n=7) during initiation antiretroviral therapy (ART) that did not include protease or non-nucleoside reverse transcriptase inhibitors.

Author(s): 
Hulgan, Todd
Donahue, John P.
Smeaton, Laura
Pu, Minya
Wang, Hongying
Lederman, Michael M.
Smith, Kimberly
Valdez, Hernan
Pilcher, Christopher
Haas, David W.
AIDS Clinical Trials Group Study A5138 Team
Publication Title: 
AIDS research and human retroviruses

The high rate of HIV-1 mutation and the frequent sexual transmission highlight the need for novel therapeutic modalities with broad activity against both CXCR4 (X4) and CCR5 (R5)-tropic viruses. We investigated a large number of natural products, and from Sargassum fusiforme we isolated and identified palmitic acid (PA) as a natural small bioactive molecule with activity against HIV-1 infection. Treatment with 100 microM PA inhibited both X4 and R5 independent infection in the T cell line up to 70%.

Author(s): 
Lee, David Y.-W.
Lin, Xudong
Paskaleva, Elena E.
Liu, Yanze
Puttamadappa, Shadakshara S.
Thornber, Carol
Drake, James R.
Habulin, Maja
Shekhtman, Alexander
Canki, Mario

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