Celastrus

Publication Title: 
Planta Medica

The seed oil obtained from Celastrus paniculatus has been used in Ayurvedic medicine for the treatment of several complaints including intestinal disorders. The muscle relaxing activity of C. paniculatus has been studied in vitro on isolated preparations of rat intestine. C. paniculatus seeds extract (0.001 - 100 microg/mL) produced a concentration-related relaxation of the rat ileum [IC (50) (95 % c. l.) 0.24 (0.13 - 0.45) microg/mL]. Among the four fractions ( n-hexane, CCl (4), CHCl (3), n-BuOH) obtained from the methanolic extract of C.

Author(s): 
Borrelli, Francesca
Borbone, Nicola
Capasso, Raffaele
Montesano, Domenico
Izzo, Angelo A.
De Marino, Simona
Capasso, Francesco
Ferrara, Lydia
Longo, Rocco
Zollo, Franco
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL IMPORTANCE: Celastrus paniculatus Willd. (Celastraceae) is an Ayurvedic remedy used for the treatment of a number of diseases, including bowel spasms. AIM OF THE STUDY: To investigate the mode of the relaxing action of a methanolic extract prepared from the seeds of Celastrus paniculatus (CPE, 0.0001-10 microg/mL) in the rat ileum and to try to confirm on human tissues the intestinal pharmacological activity of the extract.

Author(s): 
Borrelli, Francesca
Borbone, Nicola
Capasso, Raffaele
Montesano, Domenico
De Marino, Simona
Aviello, Gabriella
Aprea, Giovanni
Masone, Stefania
Izzo, Angelo A.
Publication Title: 
Arthritis Research & Therapy

Complementary and alternative medicine products are increasingly being used for the treatment of autoimmune diseases. However, the mechanisms of action of these agents are not fully defined. Using the rat adjuvant arthritis (AA) model of human rheumatoid arthritis, we determined whether the ethanol extract of Celastrus aculeatus Merr. (Celastrus), a Chinese herb, can down-modulate the severity of AA, and also examined the Celastrus-induced changes in immune responses to the disease-related antigen mycobacterial heat-shock protein 65 (Bhsp65).

Author(s): 
Tong, Li
Moudgil, Kamal D.
Publication Title: 
The Journal of Biological Chemistry

Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and articular damage. Proinflammatory cytokines, antibodies, and matrix-degrading enzymes orchestrate the pathogenic events in autoimmune arthritis. Accordingly, these mediators of inflammation are the targets of several anti-arthritic drugs. However, the prolonged use of such drugs is associated with severe adverse reactions. This limitation has necessitated the search for less toxic natural plant products that possess anti-arthritic activity.

Author(s): 
Venkatesha, Shivaprasad H.
Yu, Hua
Rajaiah, Rajesh
Tong, Li
Moudgil, Kamal D.
Publication Title: 
The Journal of Biological Chemistry

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by bone erosion and cartilage destruction in the joints. Many of the conventional antiarthritic drugs are effective in suppressing inflammation, but they do not offer protection against bone damage. Furthermore, the prolonged use of these drugs is associated with severe adverse reactions. Thus, new therapeutic agents that can control both inflammation and bone damage but with minimal side effects are sought.

Author(s): 
Nanjundaiah, Siddaraju M.
Venkatesha, Shivaprasad H.
Yu, Hua
Tong, Li
Stains, Joseph P.
Moudgil, Kamal D.
Publication Title: 
International Immunopharmacology

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints. The prolonged use of non-steroidal anti-inflammatory drugs and other newer drugs is associated with severe adverse reactions. Therefore, there is a need for newer anti-arthritic agents. Celastrol, a bioactive component of the Chinese herb Celastrus, possesses anti-arthritic activity as tested in the adjuvant arthritis (AA) model of rheumatoid arthritis (RA). However, the mechanism of action of Celastrol has not been fully defined.

Author(s): 
Yu, Hua
Venkatesha, Shivaprasad H.
Moudgil, Kamal D.
Publication Title: 
International Journal of Immunopathology and Pharmacology

Rheumatoid arthritis (RA) is a debilitating autoimmune disease of global prevalence and the disease process primarily targets the synovial joints. Despite improvements in the treatment of RA over the past decade, there still is a need for new therapeutic agents that are efficacious, less expensive, and free of severe adverse reactions. Celastrus has been used in China for centuries for the treatment of rheumatic diseases. Furthermore, we previously reported that ethanol extract of Celastrus aculeatus Merr. (Celastrus) attenuates adjuvant-induced arthritis (AA) in rats.

Author(s): 
Yu, H.
Venkatesha, S. H.
Nanjundaiah, S.
Tong, L.
Moudgil, K. D.
Publication Title: 
Bioorganic & Medicinal Chemistry

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial joints, deformities, and disability. The prolonged use of conventional anti-inflammatory drugs is associated with severe adverse effects. Therefore, there is an urgent need for safer and less expensive therapeutic products. Celastrol is a bioactive component of Celastrus, a traditional Chinese medicine, and it possesses anti-arthritic activity. However, the mechanism of action of Celastrol remains to be fully defined.

Author(s): 
Venkatesha, Shivaprasad H.
Astry, Brian
Nanjundaiah, Siddaraju M.
Yu, Hua
Moudgil, Kamal D.
Publication Title: 
The Journal of Biological Chemistry

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by bone erosion and cartilage destruction in the joints. Many of the conventional antiarthritic drugs are effective in suppressing inflammation, but they do not offer protection against bone damage. Furthermore, the prolonged use of these drugs is associated with severe adverse reactions. Thus, new therapeutic agents that can control both inflammation and bone damage but with minimal side effects are sought.

Author(s): 
Nanjundaiah, Siddaraju M.
Venkatesha, Shivaprasad H.
Yu, Hua
Tong, Li
Stains, Joseph P.
Moudgil, Kamal D.
Publication Title: 
Bioorganic & Medicinal Chemistry

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial joints, deformities, and disability. The prolonged use of conventional anti-inflammatory drugs is associated with severe adverse effects. Therefore, there is an urgent need for safer and less expensive therapeutic products. Celastrol is a bioactive component of Celastrus, a traditional Chinese medicine, and it possesses anti-arthritic activity. However, the mechanism of action of Celastrol remains to be fully defined.

Author(s): 
Venkatesha, Shivaprasad H.
Astry, Brian
Nanjundaiah, Siddaraju M.
Yu, Hua
Moudgil, Kamal D.
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