Cell Adhesion Molecules

Publication Title: 
Cellular and molecular life sciences: CMLS

Cell adhesion molecule 1 (CADM1), expressed by human lung mast cells (HLMCs), mediates their adhesion to airway smooth muscle (ASM), and contributes to ASM-dependent HLMC proliferation and survival. CADM1 is expressed in alternatively spliced isoforms, but those present in HLMCs and their function are not known. We cloned three functional and one cryptic non-functional isoform with alternative splicing between exons 7/11 and 1/2, respectively, from HLMCs and human MC lines (HMC-1 and LAD2).

Author(s): 
Moiseeva, Elena P.
Leyland, Mark L.
Bradding, Peter
Publication Title: 
Journal of Cosmetic Dermatology

INTRODUCTION: Imedeenô is a cosmeceutical that provides nutrients to the skin. One of its active ingredients is the Marine Complexô (MC). AIM: The aim of this study was to evaluate whether MC affects skin morphogenesis differently in female and male human skin equivalents (HSEs). METHODS: Human skin equivalents were established with cells obtained from female or male donors between 30 and 45 years of age and cultured for seven or 11 weeks in the presence or absence of MC.

Author(s): 
Rietveld, Marion
Janson, David
Siamari, Rachida
Vicanova, Jana
Andersen, Maja Troest
El Ghalbzouri, Abdoelwaheb
Publication Title: 
Molecular Medicine (Cambridge, Mass.)

Cerebral malaria (CM) is associated with excessive inflammatory responses and endothelial activation. Sphingosine 1-phosphate (S1P) is a signaling sphingolipid implicated in regulating vascular integrity, inflammation and T-cell migration. We hypothesized that altered S1P signaling during malaria contributes to endothelial activation and inflammation, and show that plasma S1P levels were decreased in Ugandan children with CM compared with children with uncomplicated malaria.

Author(s): 
Finney, Constance Am
Hawkes, Cheryl A.
Kain, Dylan C.
Dhabangi, Aggrey
Musoke, Charles
Cserti-Gazdewich, Christine
Oravecz, Tamas
Liles, W. Conrad
Kain, Kevin C.
Publication Title: 
Circulation

BACKGROUND: Although diabetes confers an increased propensity toward accelerated atherogenesis, data are lacking on monocyte activity in type 2 diabetic patients with (DM2-MV) and without (DM2) macrovascular disease compared with control subjects.

Author(s): 
Devaraj, S.
Jialal, I.
Publication Title: 
The Journal of Nutrition

Atherosclerosis is the leading cause of morbidity and mortality in Westernized populations. The monocyte is a crucial cell in the genesis of the atherosclerotic lesion and is present during all stages of atherosclerosis. alpha-Tocopherol (AT) is the most active component of the vitamin E family and is the principal and most potent lipid-soluble antioxidant in plasma and LDL.

Author(s): 
Jialal, I.
Devaraj, S.
Kaul, N.
Publication Title: 
American Journal of Physiology. Heart and Circulatory Physiology

The antiatherogenic effects of soy isoflavone consumption have been demonstrated in a variety of studies. However, the mechanisms involved remain poorly defined. Adhesion of monocytes to vascular endothelial cells is a key step within the inflammatory cascade that leads to atherogenesis. Many factors, including the physical forces associated with blood flow, regulate this process.

Author(s): 
Chacko, Balu K.
Chandler, Robert T.
Mundhekar, Ameya
Khoo, Nicholas
Pruitt, Heather M.
Kucik, Dennis F.
Parks, Dale A.
Kevil, Christopher G.
Barnes, Stephen
Patel, Rakesh P.
Publication Title: 
Diabetes

Type 1 diabetes is associated with increased vascular complications, and monocytes are pivotal cells in atherogenesis. However, there are few data on monocyte function and inflammation in type 1 diabetes. The aim of this study was to compare monocyte function and biomarkers of inflammation in type 1 diabetic subjects without macrovascular disease with that in matched control subjects (n = 52 per group).

Author(s): 
Devaraj, Sridevi
Glaser, Nicole
Griffen, Steve
Wang-Polagruto, Janice
Miguelino, Eric
Jialal, Ishwarlal
Publication Title: 
Arteriosclerosis, Thrombosis, and Vascular Biology

OBJECTIVE: Excess iron may increase oxidative stress and play a role in vascular inflammation and atherosclerosis. Here we determined whether the iron chelator, desferrioxamine (DFO), ameliorates oxidative stress and cellular adhesion molecule expression in a murine model of local inflammation. METHODS AND RESULTS: Dorsal air pouches were created in C57BL/6J mice by subcutaneous injection of air. DFO (100 mg/kg body weight) was injected into the air pouch once a day for two days followed immediately on the second day by lipopolysaccharide (LPS; 2.5 mg/kg body weight).

Author(s): 
Li, Lixin
Frei, Balz
Publication Title: 
Clinical Nutrition (Edinburgh, Scotland)

BACKGROUND & AIMS: Abscisic acid (ABA) has shown effectiveness in ameliorating inflammation in obesity, diabetes and cardiovascular disease models. The objective of this study was to determine whether ABA prevents or ameliorates experimental inflammatory bowel disease (IBD). METHODS: C57BL/6J mice were fed diets with or without ABA (100mg/kg) for 35 days prior to challenge with 2.5% dextran sodium sulfate (DSS). The severity of clinical disease was assessed daily.

Author(s): 
Guri, Amir J.
Hontecillas, Raquel
Bassaganya-Riera, Josep
Publication Title: 
American Journal of Physiology. Cell Physiology

The consumption of cacao-derived (i.e., cocoa) products provides beneficial cardiovascular effects in healthy subjects as well as individuals with endothelial dysfunction such as smokers, diabetics, and postmenopausal women. The vascular actions of cocoa are related to enhanced nitric oxide (NO) production. These actions can be reproduced by the administration of the cacao flavanol (-)-epicatechin (EPI).

Author(s): 
Ramirez-Sanchez, Israel
Maya, Lisandro
Ceballos, Guillermo
Villarreal, Francisco

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