Cell Hypoxia

Publication Title: 
Journal of Stem Cells

Cancer stem cells (CSCs) are stem-like tumor populations that are reported to contribute towards tumor growth, maintenance and recurrence after therapy. Hypoxia increases CSC fraction and promotes acquisition of a stem-cell-like state. Cancer stem cells are critically dependant on the hypoxia-inducible factor-1 (HIF-1) for survival, self-renewal, tumor growth and maintenance of their undifferentiated phenotype.

Bhargav, Hemant
Metri, Kashinath
Raghuram, Nagarathna
Ramarao, Nagendra Hongasandra
Koka, Prasad S.
Publication Title: 
Biochemical and Biophysical Research Communications

This initial report presents a neonatal rat model with exposure to a transient intermittent hypoxia (IH), which results in a persisting diabetes-like condition in the young rats. Twenty-five male pups were treated at postnatal day 1 with IH exposure by alternating the level of oxygen between 10.3% and 20.8% for 5h. The treated animals were then maintained in normal ambient oxygen condition for 3 week and compared to age-matched controls. The IH treated animals exhibited a significantly higher fasting glucose level than the control animals (237.00 ± 19.66 mg/dL vs.

Pae, Eung-Kwon
Ahuja, Bhoomika
Kim, Marieyerie
Kim, Gyuyoup
Publication Title: 
Biological & Pharmaceutical Bulletin

Nicotiflorin is a single component extracted from traditional Chinese medicine Flos Carthami. In this study, we investigated its neuroprotection in permanent focal cerebral ischemia model in rats, and in an in vitro model of ischemia. At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduced brain infarct volume and neurological deficits. For primarily cultured neurons suffered 2 h hypoxia followed by 24 h reoxygenation, nicotiflorin significantly attenuated cell death and reduced LDH release.

Li, Runping
Guo, Meili
Zhang, Ge
Xu, Xiongfei
Li, Quan
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To observe the effects of Tribulus terrestris L. saponion (TTLS) on apoptosis in cortical neurons induced by hypoxia-reoxygenation in rats. METHODS: Primary culture of rat cortical neurons was performed in vitro. A model of apoptosis of cortical neurons was established by hypoxia and reoxygenation. Hypoxia for 3 h in neural cells was induced with mixture of 95% N(2) and 5% CO(2), and then reoxygenation in neural cells was induced with mixture of 95% O(2) and 5% CO(2) for 12 h.

Liu, Xue-Mei
Huang, Qi-Fu
Zhang, Yun-ling
Lou, Jin-Li
Liu, Hong-Sheng
Zheng, Hong
Publication Title: 
International Journal of Cancer. Journal International Du Cancer

Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal malignancies characterized by an intense tumor stroma with hypoperfused regions, a significant inflammatory response and pronounced therapy resistance. New therapeutic agents are urgently needed. The plant-derived agent triptolide also known as "thunder god vine" has a long history in traditional Chinese medicine for treatment of rheumatoid arthritis and cancer and is now in a clinical phase II trial for establishing the efficacy against a placebo.

Liu, Li
Salnikov, Alexei V.
Bauer, Nathalie
Aleksandrowicz, Ewa
Labsch, Sabrina
Nwaeburu, Clifford
Mattern, Jürgen
Gladkich, Jury
Schemmer, Peter
Werner, Jens
Herr, Ingrid
Publication Title: 
Cellular and molecular life sciences: CMLS

Hypoxic/ischemic disruption of ionic homeostasis is a critical trigger of neuronal injury/death in the brain. There is, however, no promising strategy against such pathophysiologic change to protect the brain from hypoxic/ischemic injury. Here, we present a novel finding that activation of delta-opioid receptors (DOR) reduced anoxic Na+ influx in the mouse cortex, which was completely blocked by DOR antagonism with naltrindole.

Kang, Xuezhi
Chao, Dongman
Gu, Quanbao
Ding, Guanghong
Wang, Yingwei
Balboni, Gianfranco
Lazarus, Lawrence H.
Xia, Ying


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