Cell Migration Inhibition

Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Acetyl-11-keto-beta-boswellic acid (AKBA), a component of an Ayurvedic therapeutic plant Boswellia serrata, is a pentacyclic terpenoid active against a large number of inflammatory diseases, including cancer, arthritis, chronic colitis, ulcerative colitis, Crohn's disease, and bronchial asthma, but the mechanism is poorly understood.

Author(s): 
Takada, Yasunari
Ichikawa, Haruyo
Badmaev, Vladimir
Aggarwal, Bharat B.
Publication Title: 
Molecular Cancer Therapeutics

The plant Withania somnifera Dunal (Ashwagandha), also known as Indian ginseng, is widely used in the Ayurvedic system of medicine to treat tumors, inflammation, arthritis, asthma, and hypertension. Chemical investigation of the roots and leaves of this plant has yielded bioactive withanolides. Earlier studies showed that withanolides inhibit cyclooxygenase enzymes, lipid peroxidation, and proliferation of tumor cells.

Author(s): 
Ichikawa, Haruyo
Takada, Yasunari
Shishodia, Shishir
Jayaprakasam, Bolleddula
Nair, Muraleedharan G.
Aggarwal, Bharat B.
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Acetyl-11-keto-beta-boswellic acid (AKBA), a component of an Ayurvedic therapeutic plant Boswellia serrata, is a pentacyclic terpenoid active against a large number of inflammatory diseases, including cancer, arthritis, chronic colitis, ulcerative colitis, Crohn's disease, and bronchial asthma, but the mechanism is poorly understood.

Author(s): 
Takada, Yasunari
Ichikawa, Haruyo
Badmaev, Vladimir
Aggarwal, Bharat B.
Publication Title: 
Molecular Cancer Therapeutics

The plant Withania somnifera Dunal (Ashwagandha), also known as Indian ginseng, is widely used in the Ayurvedic system of medicine to treat tumors, inflammation, arthritis, asthma, and hypertension. Chemical investigation of the roots and leaves of this plant has yielded bioactive withanolides. Earlier studies showed that withanolides inhibit cyclooxygenase enzymes, lipid peroxidation, and proliferation of tumor cells.

Author(s): 
Ichikawa, Haruyo
Takada, Yasunari
Shishodia, Shishir
Jayaprakasam, Bolleddula
Nair, Muraleedharan G.
Aggarwal, Bharat B.
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Selenoprotein K (Sel K) is a selenium-containing protein for which no function has been identified. We found that Sel K is an endoplasmic reticulum transmembrane protein expressed at relatively high levels in immune cells and is regulated by dietary selenium. Sel K(-/-) mice were generated and found to be similar to wild-type controls regarding growth and fertility. Immune system development was not affected by Sel K deletion, but specific immune cell defects were found in Sel K(-/-) mice.

Author(s): 
Verma, Saguna
Hoffmann, Fukun W.
Kumar, Mukesh
Huang, Zhi
Roe, Kelsey
Nguyen-Wu, Elizabeth
Hashimoto, Ann S.
Hoffmann, Peter R.
Publication Title: 
Homeopathy: The Journal of the Faculty of Homeopathy

Atropa belladonna and Echinacea angustifolia have been used in homeopathy as modulators of inflammatory processes, in simple potency or 'accord of potencies', as recommended by homotoxicology. We evaluated their effects on leukocyte migration and macrophage activity induced by experimental peritonitis in vivo. Mice were injected (i.p.) with LPS (1.0mg/kg) and treated (0.3ml/10g/day, s.c.) with different commercial forms of these medicines.

Author(s): 
Pedalino, C. M. V.
Perazzo, F. F.
Carvalho, J. C. T.
Martinho, K. S.
Massoco, C. de O.
Bonamin, L. V.
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