Cell Physiological Phenomena

Publication Title: 
Methods (San Diego, Calif.)

The performance of cell lines used for the production of biotherapeutic proteins typically depends on the number of cells in culture, their specific growth rate, their viability and the cell specific productivity (qP). Therefore both cell line development and process development are trying to (a) improve cell proliferation to reduce lag-phase and achieve high number of cells; (b) delay cell death to prolong the production phase and improve culture longevity; (c) and finally, increase qP.

Author(s): 
Kumar, Niraj
Borth, Nicole
Publication Title: 
Methods (San Diego, Calif.)

The performance of cell lines used for the production of biotherapeutic proteins typically depends on the number of cells in culture, their specific growth rate, their viability and the cell specific productivity (qP). Therefore both cell line development and process development are trying to (a) improve cell proliferation to reduce lag-phase and achieve high number of cells; (b) delay cell death to prolong the production phase and improve culture longevity; (c) and finally, increase qP.

Author(s): 
Kumar, Niraj
Borth, Nicole
Publication Title: 
Journal of the Science of Food and Agriculture

Besides synthesizing nutritive substances (proteins, fats and carbohydrates) for energy and growth, plants produce numerous non-energetic so-called secondary metabolites (mainly polyphenols) that allow them to protect themselves against infections and other types of hostile environments. Interestingly, these polyphenols often provide cells with valuable bioactive properties for the maintenance of their functions and homeostasis (signaling, gene regulation, protection against acquired or infectious diseases, etc.) both in humans and animals.

Author(s): 
LanÁon, Allan
Michaille, Jean-Jacques
Latruffe, Norbert
Publication Title: 
Advances in Food Research
Author(s): 
Lepkovsky, S.
Publication Title: 
Annual Review of Nutrition
Author(s): 
Emken, E. A.
Publication Title: 
Clinics in Geriatric Medicine

A recent series of advances in the understanding of mechanisms responsible for senescence have opened up potential avenues for delaying its onset and that of associated chronic diseases. Because the onset of senescence, like other biological processes, appears to be subject to regulation, advantage is being taken of pathways involved in this regulation to develop therapeutic interventions.

Author(s): 
Kirkland, James L.
Publication Title: 
Medical Hypotheses

The precise mechanistic sequence producing the beneficial effects on health and lifespan seen with interventions as diverse as caloric restriction, intermittent fasting, exercise, and consumption of dietary phytonutrients is still under active characterization, with large swaths of the research community kept in relative isolation from one another.

Author(s): 
Tapia, Patrick C.
Publication Title: 
The Journal of Nutritional Biochemistry

Aging is associated with a reduced ability to cope with physiological challenges. Although the mechanisms underlying age-related alterations in stress tolerance are not well defined, many studies support the validity of the oxidative stress hypothesis, which suggests that lowered functional capacity in aged organisms is the result of an increased generation of reactive oxygen and nitrogen species.

Author(s): 
Calabrese, Vittorio
Giuffrida Stella, Anna Maria
Calvani, Menotti
Butterfield, D. Allan
Publication Title: 
Scientific American
Author(s): 
Kirkwood, Thomas
Publication Title: 
Journal of the Science of Food and Agriculture

Besides synthesizing nutritive substances (proteins, fats and carbohydrates) for energy and growth, plants produce numerous non-energetic so-called secondary metabolites (mainly polyphenols) that allow them to protect themselves against infections and other types of hostile environments. Interestingly, these polyphenols often provide cells with valuable bioactive properties for the maintenance of their functions and homeostasis (signaling, gene regulation, protection against acquired or infectious diseases, etc.) both in humans and animals.

Author(s): 
LanÁon, Allan
Michaille, Jean-Jacques
Latruffe, Norbert
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