Central Nervous System Agents

Publication Title: 
Systematic Reviews

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of children and adolescents, with a significant impact on health services and the community in terms of economic and social burdens. The objective of this systematic review will be to evaluate the comparative efficacy and safety of pharmacological and non-pharmacological treatments in children and adolescents with ADHD.

Author(s): 
Catalá-López, Ferrán
Hutton, Brian
Núñez-Beltrán, Amparo
Mayhew, Alain D.
Page, Matthew J.
Ridao, Manuel
Tobías, Aurelio
Catalá, Miguel A.
Tabarés-Seisdedos, Rafael
Moher, David
Publication Title: 
Systematic Reviews

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of children and adolescents, with a significant impact on health services and the community in terms of economic and social burdens. The objective of this systematic review will be to evaluate the comparative efficacy and safety of pharmacological and non-pharmacological treatments in children and adolescents with ADHD.

Author(s): 
Catalá-López, Ferrán
Hutton, Brian
Núñez-Beltrán, Amparo
Mayhew, Alain D.
Page, Matthew J.
Ridao, Manuel
Tobías, Aurelio
Catalá, Miguel A.
Tabarés-Seisdedos, Rafael
Moher, David
Publication Title: 
Systematic Reviews

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of children and adolescents, with a significant impact on health services and the community in terms of economic and social burdens. The objective of this systematic review will be to evaluate the comparative efficacy and safety of pharmacological and non-pharmacological treatments in children and adolescents with ADHD.

Author(s): 
Catalá-López, Ferrán
Hutton, Brian
Núñez-Beltrán, Amparo
Mayhew, Alain D.
Page, Matthew J.
Ridao, Manuel
Tobías, Aurelio
Catalá, Miguel A.
Tabarés-Seisdedos, Rafael
Moher, David
Publication Title: 
Systematic Reviews

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of children and adolescents, with a significant impact on health services and the community in terms of economic and social burdens. The objective of this systematic review will be to evaluate the comparative efficacy and safety of pharmacological and non-pharmacological treatments in children and adolescents with ADHD.

Author(s): 
Catalá-López, Ferrán
Hutton, Brian
Núñez-Beltrán, Amparo
Mayhew, Alain D.
Page, Matthew J.
Ridao, Manuel
Tobías, Aurelio
Catalá, Miguel A.
Tabarés-Seisdedos, Rafael
Moher, David
Publication Title: 
Indian Journal of Physiology and Pharmacology

Cypermethrin a widely used insecticide of Pyrethroids (type II) group, was administered in mice at two dose levels (1/10 of LD50 i.e. 2.5 mg/kg and 1/5 of LD50 i.e. 5.0 mg/kg) and pharmacodynamic interactions of insecticide were studied with centrally acting drugs viz. pentobarbital sodium, amphetamine, pentylenetetrazole, acepromazine and analgin. Cypermethrin pretreatment potentiated the actions of pentobarbital and pentylene-tetrazole as evidenced by an increase in pentobarbital induced hypnosis and duration of pentylene-tetrazole induced chemoshock seizures.

Author(s): 
Varshneya, C.
Kanwar, R. S.
Publication Title: 
Expert Opinion on Investigational Drugs

Irritable bowel syndrome (IBS) is the most common condition that a physician faces in the GI clinic. Of the general population, 10 - 25% suffer from symptoms judged to be IBS. The negative impact of this disease includes not only pain, suffering and direct medical expenses but also significant social and job-related consequences. IBS can be the result of dysfunction in any part of the brain-gut axis: alterations in the CNS caused by psychological or other factors, abnormal gastrointestinal motility, or heightened visceral sensations.

Author(s): 
Farhadi, A.
Bruninga, K.
Fields, J.
Keshavarzian, A.
Publication Title: 
Indian Journal of Medical Sciences

In the present study, half of the pups of a litter were undernourished by 12 h daily maternal deprivation from day 5 to day 18 postnatal and were subsequently nutritionally rehabilitated. Responses of CNS-acting drugs (morphine analgesia, pentobarbitone sodium hypnosis, haloperidol catalepsy) were studied at the age of day 9, 12 and 18 in maternally deprived and of day 25 in nutritionally rehabilitated new born rats as compared to that of their nourished littermates.

Author(s): 
Singh, K. P.
Sanyal, A. K.
Publication Title: 
Journal of Pharmacy & Pharmaceutical Sciences: A Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques

PURPOSE: The present study evaluates some azetidin-2-ones derivatives for their central nervous system (CNS) modulating activities. The compounds were chosen from a series (5a-o) which were previously synthesized and evaluated for hypolipidemic and antihyperglycemic activity based on the predictions made by the computer software "Prediction of Activity Spectra for Substances (PASS)".

Author(s): 
Goel, Rajesh K.
Singh, Amanpreet
Naidu, Pattipati S.
Mahajan, Mohinder P.
Kulkarni, Shrinivas K.
Publication Title: 
British Journal of Pharmacology

Despite the generally held view that alcohol is an unspecific pharmacological agent, recent molecular pharmacology studies demonstrated that alcohol has only a few known primary targets. These are the NMDA, GABA(A), glycine, 5-hydroxytryptamine 3 (serotonin) and nicotinic ACh receptors as well as L-type Ca(2+) channels and G-protein-activated inwardly rectifying K(+) channels.

Author(s): 
Vengeliene, V.
Bilbao, A.
Molander, A.
Spanagel, R.
Publication Title: 
Fitoterapia

The effect of detoxification on Strychnos nux-vomica seeds by traditional processing with aloe and ginger juices (B), by frying in cow ghee (C), and by boiling in cow milk (D) was investigated. The ethanolic extracts of these samples were subjected to spontaneous motor activity (SMA), pentobarbitone-induced hypnosis, PTZ induced convulsions, diazepam-assisted protection, and morphine-induced catalepsy. All samples reduced SMA and inhibited catalepsy.

Author(s): 
Katiyar, Chandrakant
Kumar, Abhishek
Bhattacharya, S. K.
Singh, R. S.

Pages

Subscribe to RSS - Central Nervous System Agents