Central Nervous System Sensitization

Publication Title: 
Neuroscience and Biobehavioral Reviews

Anxiety disorders increase risk for the early development of several diseases of aging. Elevated inflammation, a common risk factor across diseases of aging, may play a key role in the relationship between anxiety and physical disease. However, the neurobiological mechanisms linking anxiety with elevated inflammation remain unclear. In this review, we present a neurobiological model of the mechanisms by which anxiety promotes inflammation.

Author(s): 
O'Donovan, Aoife
Slavich, George M.
Epel, Elissa S.
Neylan, Thomas C.
Publication Title: 
The British Journal of Psychiatry: The Journal of Mental Science

BACKGROUND: Bipolar disorder has a high co-occurrence with substance use disorders, but the pathophysiological mechanisms have not been adequately explored. AIMS: To review the role of stress in the onset and recurrence of affective episodes and substance misuse. METHOD: We review the mechanisms involved in sensitisation (increased responsivity) to recurrence of stressors, mood episodes and cocaine use.

Author(s): 
Post, Robert M.
Kalivas, Peter
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