Cercopithecus aethiops

Publication Title: 
PloS One

LEDGF/p75 interacts with DNA/protein to regulate gene expression and function. Despite the recognized diversity of function of LEDGF/p75, knowledge of its transregulation is in its infancy. Here we report that LEDGF/p75 gene is TATA-less, contains GC-rich cis elements and is transcriptionally regulated by Sp1 involving small ubiquitin-like modifier (Sumo1). Using different cell lines, we showed that Sp1 overexpression increased the level of LEDGF/p75 protein and mRNA expression in a concentration-dependent fashion.

Author(s): 
Singh, Dhirendra P.
Bhargavan, Biju
Chhunchha, Bhavana
Kubo, Eri
Kumar, Anil
Fatma, Nigar
Publication Title: 
Antimicrobial Agents and Chemotherapy

The human JC polyomavirus (JCPyV) causes the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). A growing number of patients with induced or acquired immunosuppression are at risk for infection, and no effective antiviral therapy is presently available. The widely used antimalarial drug artesunate has shown broad antiviral activity in vitro but limited clinical success. The aim of this study was to investigate the effect of artesunate on JCPyV replication in vitro.

Author(s): 
Sharma, Biswa Nath
Marschall, Manfred
Rinaldo, Christine Hanssen
Publication Title: 
Antimicrobial Agents and Chemotherapy

Malaria patients are frequently coinfected with HIV and mycobacteria causing tuberculosis, which increases the use of coadministered drugs and thereby enhances the risk of pharmacokinetic drug-drug interactions. Activation of the pregnane X receptor (PXR) by xenobiotics, which include many drugs, induces drug metabolism and transport, thereby resulting in possible attenuation or loss of the therapeutic responses to the drugs being coadministered. While several artemisinin-type antimalarial drugs have been shown to activate PXR, data on nonartemisinin-type antimalarials are still missing.

Author(s): 
Piedade, Rita
Traub, Stefanie
Bitter, Andreas
Nüssler, Andreas K.
Gil, José P.
Schwab, Matthias
Burk, Oliver
Publication Title: 
BMC microbiology

BACKGROUND: Lactobacillus plantarum is considered as a safe and effective probiotic microorganism. Among various sources of isolation, traditionally fermented foods are considered to be rich in Lactobacillus spp., which can be exploited for their probiotic attribute. Antibacterial property of L. plantarum has been demonstrated against various enteric pathogens in both in vitro and in vivo systems. This study was aimed at characterizing L.

Author(s): 
Kumar, Himanshu
Rangrez, Ashraf Y.
Dayananda, Kannayakanahalli M.
Atre, Ashwini N.
Patole, Milind S.
Shouche, Yogesh S.
Publication Title: 
BMC microbiology

BACKGROUND: Lactobacillus plantarum is considered as a safe and effective probiotic microorganism. Among various sources of isolation, traditionally fermented foods are considered to be rich in Lactobacillus spp., which can be exploited for their probiotic attribute. Antibacterial property of L. plantarum has been demonstrated against various enteric pathogens in both in vitro and in vivo systems. This study was aimed at characterizing L.

Author(s): 
Kumar, Himanshu
Rangrez, Ashraf Y.
Dayananda, Kannayakanahalli M.
Atre, Ashwini N.
Patole, Milind S.
Shouche, Yogesh S.
Publication Title: 
The EMBO journal

Keap1 is a BTB-Kelch substrate adaptor protein that regulates steady-state levels of Nrf2, a bZIP transcription factor, in response to oxidative stress. We have determined the structure of the Kelch domain of Keap1 bound to a 16-mer peptide from Nrf2 containing a highly conserved DxETGE motif. The Nrf2 peptide contains two short antiparallel beta-strands connected by two overlapping type I beta-turns stabilized by the aspartate and threonine residues.

Author(s): 
Lo, Shih-Ching
Li, Xuchu
Henzl, Michael T.
Beamer, Lesa J.
Hannink, Mark
Publication Title: 
The Journal of Biological Chemistry

Keap1 is a BTB-Kelch substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex that functions as a sensor for thiol-reactive chemopreventive compounds and oxidative stress. Inhibition of Keap1-dependent ubiquitination of the bZIP transcription factor Nrf2 enables Nrf2 to activate a cyto-protective transcriptional program that counters the damaging effects of oxidative stress. In this report we have identified a member of the phosphoglycerate mutase family, PGAM5, as a novel substrate for Keap1.

Author(s): 
Lo, Shih-Ching
Hannink, Mark
Publication Title: 
Phytotherapy research: PTR

Following chemotaxonomic evidence, the PE and CHCl(3) extracts of the roots of the botanical Angelica sinensis (Oliv.) Diels (Dang Gui) were investigated for in vitro anti-TB activity, in parallel to studying their serotonergic and GABAergic potential. The activities were confirmed to overlap chemically with the neurotropic active principles present in medium lipophilic fractions.

Author(s): 
Deng, Shixin
Wang, Yuehong
Inui, Taichi
Chen, Shao-Nong
Farnsworth, Norman R.
Cho, Sanghyun
Franzblau, Scott G.
Pauli, Guido F.
Publication Title: 
The Journal of Nutrition

Pregnane X receptor (PXR) is an important component of the body's adaptive defense system responsible for the elimination of various toxic xenobiotics. PXR activation by endogenous and exogenous chemicals, including steroids, antibiotics, bile acids, and herbal compounds, results in induction of drug metabolism. We investigated the ability of the isoflavones genistein, daidzein, and the daidzein metabolite equol to activate human and mouse PXR in vitro using cell-based transient transfection studies and primary hepatocytes and in vivo in a mouse model.

Author(s): 
Li, Yilan
Ross-Viola, Jennifer S.
Shay, Neil F.
Moore, David D.
Ricketts, Marie-Louise
Publication Title: 
Journal of Ethnopharmacology

AIM OF THE STUDY: Parkinson's disease is a neurological disorder mostly effecting the elder population of the world. Currently there is no definitive treatment or cure for this disease. Therefore, in this study the composition and constituents of the aqueous extract of Banisteriopsis caapi for monoamine oxidases (MAO) inhibitory and antioxidant activities were assessed, which are relevant to the prevention of neurological disorders, including Parkinsonism.

Author(s): 
Samoylenko, Volodymyr
Rahman, Md Mostafizur
Tekwani, Babu L.
Tripathi, Lalit M.
Wang, Yan-Hong
Khan, Shabana I.
Khan, Ikhlas A.
Miller, Loren S.
Joshi, Vaishali C.
Muhammad, Ilias

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