Cercopithecus aethiops

Publication Title: 
The Journal of Membrane Biology

Cardiac slow delayed rectifier (I(Ks)) channel complex consists of KCNQ1 channel and KCNE1 auxiliary subunits. The extracellular juxtamembranous region of KCNE1 is an unstructured loop that contacts multiple KCNQ1 positions in a gating-state-dependent manner. Congenital arrhythmia-related mutations have been identified in the extracellular S1-S2 linker of KCNQ1. These mutations manifest abnormal phenotypes only when coexpressed with KCNE1, pointing to the importance of proper KCNQ1/KCNE1 interactions here in I(Ks) channel function.

Wang, Yu Hong
Jiang, Min
Xu, Xu Lin
Hsu, Kai-Ling
Zhang, Mei
Tseng, Gea-Ny
Publication Title: 
The Plant Cell

Plant phototropism is an adaptive response to changes in light direction, quantity, and quality that results in optimization of photosynthetic light harvesting, as well as water and nutrient acquisition. Though several components of the phototropic signal response pathway have been identified in recent years, including the blue light (BL) receptors phototropin1 (phot1) and phot2, much remains unknown. Here, we show that the phot1-interacting protein NONPHOTOTROPIC HYPOCOTYL3 (NPH3) functions as a substrate adapter in a CULLIN3-based E3 ubiquitin ligase, CRL3(NPH3).

Roberts, Diana
Pedmale, Ullas V.
Morrow, Johanna
Sachdev, Shrikesh
Lechner, Esther
Tang, Xiaobo
Zheng, Ning
Hannink, Mark
Genschik, Pascal
Liscum, Emmanuel
Publication Title: 
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience

NMDA receptor-dependent long-term potentiation (LTP) and depression (LTD) are forms of synaptic plasticity underlying learning and memory that are expressed through increases and decreases, respectively, in dendritic spine size and AMPA receptor (AMPAR) phosphorylation and postsynaptic localization. The A-kinase anchoring protein 79/150 (AKAP79/150) signaling scaffold regulates AMPAR phosphorylation, channel activity, and endosomal trafficking associated with LTP and LTD.

Keith, Dove J.
Sanderson, Jennifer L.
Gibson, Emily S.
Woolfrey, Kevin M.
Robertson, Holly R.
Olszewski, Kyle
Kang, Rujun
El-Husseini, Alaa
Dell'acqua, Mark L.
Publication Title: 
Microbiological Research

The aim of this study was to evaluate the antiviral potential of methanolic extract (ME) of Achyranthes aspera, an Indian folk medicine and one of its pure compound oleanolic acid (OA) against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). The ME possessed weak anti-herpes virus activity (EC50 64.4μg/ml for HSV-1 and 72.8μg/ml for HSV-2). While OA exhibited potent antiherpesvirus activity against both HSV-1 (EC50 6.8μg/ml) and HSV-2 (EC50 7.8μg/ml). The time response study revealed that the antiviral activity of ME and OA is highest at 2-6h post infection.

Mukherjee, Hemanta
Ojha, Durbadal
Bag, Paromita
Chandel, Himanshu Singh
Bhattacharyya, Souvik
Chatterjee, Tapan K.
Mukherjee, Pulok K.
Chakraborti, Sekhar
Chattopadhyay, Debprasad
Publication Title: 
Marine Drugs

Sargassum naozhouense is a brown seaweed used in folk medicine and applied for thousands of years in Zhanjiang, Guangdong province, China. This study is the first time to investigate its chemical composition and antiviral activity. On the dry weight basis, this seaweed was constituted of ca. 35.18% ash, 11.20% protein, 1.06% lipid and 47.73% total carbohydrate, and the main carbohydrate was water-soluble polysaccharide. The protein analysis indicated the presence of essential amino acids, which accounted for 36.35% of the protein.

Peng, Yan
Xie, Enyi
Zheng, Kai
Fredimoses, Mangaladoss
Yang, Xianwen
Zhou, Xuefeng
Wang, Yifei
Yang, Bin
Lin, Xiuping
Liu, Juan
Liu, Yonghong
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Plants of the genus Maytenus belong to the family Celastraceae and are widely used in folk medicine as anti-tumour, anti-asthmatic, analgesic, anti-inflammatory, antimicrobial and anti-ulcer agents, and as a treatment for stomach problems. The aim of this study was to isolate and identify active compounds with antifungal activity from Maytenus undata after a preliminary study highlighted promising activity in crude extracts. METHODS: Sequential extracts of M.

Mokoka, Tsholofelo Abednego
McGaw, Lyndy Joy
Mdee, Ladislaus Kakore
Bagla, Victor Patrick
Iwalewa, Ezekiel Olugbenga
Eloff, Jacobus Nicolaas
Publication Title: 
PloS One

Podophyllotoxin (POD) is a lignan-type toxin existing in many herbs used in folk medicine. Until now, no effective strategy is available for the management of POD intoxication. This study aims to determine the protective effects of flavonoids (quercetin and kaempferol) on POD-induced toxicity. In Vero cells, both flavonoids protected POD-induced cytotoxicity by recovering alleviating G2/M arrest, decreasing ROS generation and changes of membrane potential, and recovering microtubule structure.

Li, Juan
Sun, Hua
Jin, Lu
Cao, Wei
Zhang, Jin
Guo, Chong-Yi
Ding, Ke
Luo, Cheng
Ye, Wen-Cai
Jiang, Ren-Wang
Publication Title: 
Annals of Clinical Microbiology and Antimicrobials

BACKGROUND: The rise of antibiotic resistance among methicillin resistant Staphylococcus aureus (MRSA), have caused concerns for the treatment of MRSA infections. Hence, search for an alternative therapy for these infections is inevitable. Folk Indian medicine refers to the use of leaf and stem bark powder of Tabernaemontana alternifolia (Roxb) in treatment of skin infections, but no scientific report establishes its antibacterial activity. METHODS: Direct aqueous extracts and sequential aqueous extracts of the stem bark of T.

Marathe, Nachiket P.
Rasane, Mandar H.
Kumar, Himanshu
Patwardhan, Ankur A.
Shouche, Yogesh S.
Diwanay, Sham S.
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Adjustable control of therapeutic transgenes in engineered cell implants after transdermal and topical delivery of nontoxic trigger molecules would increase convenience, patient compliance, and elimination of hepatic first-pass effect in future therapies. Pseudomonas putida DOT-T1E has evolved the flavonoid-triggered TtgR operon, which controls expression of a multisubstrate-specific efflux pump (TtgABC) to resist plant-derived defense metabolites in its rhizosphere habitat. Taking advantage of the TtgR operon, we have engineered a hybrid P.

Gitzinger, Marc
Kemmer, Christian
El-Baba, Marie Daoud
Weber, Wilfried
Fussenegger, Martin
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Reduced caloric intake decreases arterial blood pressure in healthy individuals and improves endothelium-dependent vasodilation in obese and overweight individuals. The SIRT1 protein deacetylase mediates many of the effects of calorie restriction (CR) on organismal lifespan and metabolic pathways. However, the role of SIRT1 in regulating endothelium-dependent vasomotor tone is not known. Here we show that SIRT1 promotes endothelium-dependent vasodilation by targeting endothelial nitric oxide synthase (eNOS) for deacetylation.

Mattagajasingh, Ilwola
Kim, Cuk-Seong
Naqvi, Asma
Yamamori, Tohru
Hoffman, Timothy A.
Jung, Saet-Byel
DeRicco, Jeremy
Kasuno, Kenji
Irani, Kaikobad


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