Cerebral Hemorrhage

Publication Title: 
Acupuncture in Medicine: Journal of the British Medical Acupuncture Society

BACKGROUND: Spontaneous intracerebral haemorrhage (ICH) is the most devastating subtype of stroke, but there is currently no evidence-based treatment strategy. Acupuncture is a well-known traditional Chinese therapy for stroke-induced disability, and GV20 is the commonly used acupuncture point. OBJECTIVE: To evaluate the efficacy of GV20-based acupuncture in animal models of acute ICH. METHODS: Studies of GV20-based acupuncture in animal models of acute ICH were identified from six databases up to July 2013.

Li, Hui-Qin
Li, Ji-Huang
Liu, Ai-Ju
Ye, Mai-yun
Zheng, Guo-Qing
Publication Title: 
Stroke; a Journal of Cerebral Circulation

BACKGROUND AND PURPOSE: Fruits and vegetables are known for their beneficial effects on chronic diseases. The purpose of the present study was to investigate the protective effect of a diet rich in fruits and vegetables on total stroke mortality and its 2 main subtypes in men and women separately. METHODS: A prospective cohort study of 40 349 Japanese men and women was initiated in 1980-1981 and followed until 1998. Fruit and vegetable intake was assessed at baseline on the basis of the response to a food frequency questionnaire.

Sauvaget, C.
Nagano, J.
Allen, N.
Kodama, K.
Publication Title: 
Journal of Neurology, Neurosurgery, and Psychiatry

Three cases with intracranial lesions developed evidence of disseminated intravascular coagulation which was confirmed at necropsy. The factors engendering this state, including release of potent thromboplastin from neural tissue are discussed and the danger of this intermediary mechanism of disease increasing the mortality of intracranial disease is demonstrated. Careful haematological investigation of all patients with intracranial disease is therefore advised, especially if they manifest evidence of a bleeding tendency.

Preston, F. E.
Malia, R. G.
Sworn, M. J.
Timperley, W. R.
Blackburn, E. K.
Publication Title: 
Life Sciences

AIM: To investigate the association between vasculopathy and survival during experimental cerebral malaria (ECM), and to determine whether targeting the endothelin-1 (ET-1) pathway alone or in combination with the anti-malaria drug artemether (a semi-synthetic derivative of artemisinin) will improve microvascular hemorrhage and survival. MAIN METHODS: C57BL/6 mice infected with Plasmodium berghei ANKA (PbA) were randomly assigned to four groups: no treatment, artemether treated, ET(A) receptor antagonist (HJP-272) treated, or HJP-272 and artemether treated.

Dai, Minxian
Freeman, Brandi
Bruno, Fernando P.
Shikani, Henry J.
Tanowitz, Herbert B.
Weiss, Louis M.
Reznik, Sandra E.
Stephani, Ralph A.
Desruisseaux, Mahalia S.
Publication Title: 
Brain: A Journal of Neurology

Because heme oxygenase (HO) is the rate limiting enzyme in the degradation of the pro-oxidant hemin/heme from blood, here we investigated the contribution of the inducible HO-1 to early brain injury produced by intracerebral haemorrhage (ICH). We found that after induction of ICH, HO-1 proteins were highly detectable in the peri-ICH region predominantly in microglia/macrophages and endothelial cells. Remarkably, the injury volume was significantly smaller in HO-1 knockout (HO-1-/-) mice than in wild-type controls 24 and 72 h after ICH.

Wang, Jian
Doré, Sylvain
Publication Title: 
Free Radical Biology & Medicine

Nrf2 is a key transcriptional factor for antioxidant response element (ARE)-regulated genes. While its beneficial role has been described for stroke, its contribution to intracerebral hemorrhage (ICH)-induced early brain injury remains to be determined. Using wild-type (WT) and Nrf2 knockout (Nrf2(-/-)) mice, the role of Nrf2 in ICH induced by intracerebral injection of collagenase was investigated.

Wang, Jian
Fields, Jocelyn
Zhao, Chunying
Langer, John
Thimmulappa, Rajesh K.
Kensler, Thomas W.
Yamamoto, Masayuki
Biswal, Shyam
Doré, Sylvain
Publication Title: 

OBJECTIVE: To assess the feasibility, safety, and efficacy of Ginkgo biloba extract (GBE) on delaying the progression to cognitive impairment in normal elderly aged 85 and older. METHODS: Randomized, placebo-controlled, double-blind, 42-month pilot study with 118 cognitively intact subjects randomized to standardized GBE or placebo. Kaplan-Meier estimation, Cox proportional hazard, and random-effects models were used to compare the risk of progression from Clinical Dementia Rating (CDR) = 0 to CDR = 0.5 and decline in episodic memory function between GBE and placebo groups.

Dodge, H. H.
Zitzelberger, T.
Oken, B. S.
Howieson, D.
Kaye, J.
Publication Title: 
Experimental Neurology

Intraventricular hemorrhage (IVH) results in white matter injury and hydrocephalus in premature infants. Chondroitin sulfate proteoglycans (CSPGs)-neuorcan, brevican, versican, aggrecan and phosphacan-are unregulated in the extracellular matrix after brain injury, and their degradation enhances plasticity of the brain. Therefore, we hypothesized that CSPG levels were elevated in the forebrain of premature infants with IVH and that in vivo degradation of CSPGs would enhance maturation of oligodendrocyte, augment myelination, promote neurological recovery, and minimize hydrocephalus.

Vinukonda, Govindaiah
Zia, Muhammad T.
Bhimavarapu, Bala B. R.
Hu, Furong
Feinberg, Michelle
Bokhari, Aqiba
Ungvari, Zoltan
Fried, Victor A.
Ballabh, Praveen
Publication Title: 
The American Journal of Chinese Medicine

In osteoarthritis deformans and rheumatoid arthritis of the knee and in disorders in motility of the knee joint after cerebral hemorrhage and thrombosis, acupuncture was applied to the normal side at the symmetrical part to the lesion and flection-extension exercise and massage on the affected joint were carried out as rehabilitation (Reha) during the time the needles were used. A most remarkable cure rate was obtained in osteoarthritis deformans of the knee when treated with acupuncture on the normal side and flection-extension exercise and massage on the affected part.

Arichi, S.
Arichi, H.
Toda, S.
Publication Title: 

Four patients undergoing cervical spinal manipulations for nonneurologic diseases and with no previous neurologic signs or symptoms all developed significant neurologic deficits, one fatal, following manipulations of the cervical spine. Both the literature and the authors' series show that a number of patients have a prodrome prior to the onset of neurologic changes. There is no established therapy for the syndrome. Perhaps prevention is the best means of reducing neurologic injury.

Raskind, R.
North, C. M.


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