Ceruletide

Publication Title: 
World journal of gastroenterology: WJG

AIM: To observe the apoptosis and oncosis of pancreatic acinar cells and secondary inflammatory reaction in pancreatic tissue from rats with acute pancreatitis (AP), and the influences of artemisinin on them. METHODS: AP was induced by 4 intraperitoneal injections of caerulein at 1 h intervals. To induce apoptosis, solution of artemisinin (50 mg/kg) was given intraperitoneally 1, 12, 24 and 36 h after the last caerulein injection. Histological examination of impairment of pancreatic tissue and detection of serum amylase were performed to evaluate the severity of acute pancreatitis.

Author(s): 
Zhao, Ming
Xue, Dong-Bo
Zheng, Biao
Zhang, Wei-Hui
Pan, Shang-ha
Sun, Bei
Publication Title: 
The Indian Journal of Medical Research

BACKGROUND & OBJECTIVES: Curcuma longa (turmeric) has a long history of use in Ayurvedic medicine as a treatment for inflammatory conditions. The purpose of the present study was to investigate the preventive effects of curcumin against acute pancreatitis (AP) induced by caerulein in mouse and to elucidate possible mechanism of curcumin action. METHODS: Curcumin (50 mg/kg/day) was intraperitoneally injected to Kun Ming male mice for 6 days, followed by injection of caerulein to induce AP.

Author(s): 
Yu, Wen-Guang
Xu, Gang
Ren, Gui-Jie
Xu, Xia
Yuan, Hui-Qing
Qi, Xiao-Li
Tian, Ke-Li
Publication Title: 
The Indian Journal of Medical Research

BACKGROUND & OBJECTIVES: Curcuma longa (turmeric) has a long history of use in Ayurvedic medicine as a treatment for inflammatory conditions. The purpose of the present study was to investigate the preventive effects of curcumin against acute pancreatitis (AP) induced by caerulein in mouse and to elucidate possible mechanism of curcumin action. METHODS: Curcumin (50 mg/kg/day) was intraperitoneally injected to Kun Ming male mice for 6 days, followed by injection of caerulein to induce AP.

Author(s): 
Yu, Wen-Guang
Xu, Gang
Ren, Gui-Jie
Xu, Xia
Yuan, Hui-Qing
Qi, Xiao-Li
Tian, Ke-Li
Publication Title: 
American Journal of Physiology. Gastrointestinal and Liver Physiology

The inflammatory response during pancreatitis regulates necrotic and apoptotic rates of parenchymal cells. Neutrophil depletion by use of anti-polymorphonuclear serum (anti-PMN) increases apoptosis in experimental pancreatitis but the mechanism has not been determined. Our study was designed to investigate signaling mechanisms in pancreatic parenchymal cells regulating death responses with neutrophil depletion. Rats were neutrophil depleted with anti-PMN treatment. Then cerulein pancreatitis was induced, followed by measurements of apoptosis signaling pathways.

Author(s): 
Nakamura, Yuji
Do, Jae Hyuk
Yuan, Jingzhen
Odinokova, Irina V.
Mareninova, Olga
Gukovskaya, Anna S.
Pandol, Stephen J.
Publication Title: 
Hepatobiliary & pancreatic diseases international: HBPD INT

BACKGROUND: Traditional Chinese medicine is a potent agent in the management of clinical and experimental acute pancreatitis (AP), but the molecular mechanism of its therapeutic action is unclear. Numerous experimental and clinical studies have shown that platelet endothelial cell adhesion molecule-1 (PECAM-1) is pivotal to leukocyte recruitment, which results in microcirculatory injury during inflammation, but its role in acute pancreatitis is poorly understood.

Author(s): 
Gao, Hong-Kai
Zhou, Zong-guang
He, Tao
Chen, You-Qin
Han, Fang-Hai
Wang, Cun
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

OBJECTIVE: To investigate the mechanism of Chaiqin Chengqi Decoction (CQCQD), a compound of traditional Chinese herbal medicine, acting on the pancreatic acinar cell calcium overload in rats with acute pancreatitis (AP). METHODS: A total of 30 SD rats were randomly divided into normal control group, untreated group and CQCQD group (n=10, respectively). AP was induced in rats by caerulein (5x50 mug/kg) intraperitoneal injection within 4 h.

Author(s): 
Xue, Ping
Deng, Li-Hui
Zhang, Zhao-da
Yang, Xiao-nan
Xia, Qing
Xiang, Da-Kai
Huang, Lei
Wan, Mei-Hua
Zhang, Hai-Yan
Subscribe to RSS - Ceruletide