Chalcones

Publication Title: 
Phytochemical analysis: PCA

Triphala is an anti-oxidant-rich herbal formulation containing fruits of Emblica officinalis, Terminalia chebula and T. belerica in equal proportions. The preparation is frequently used in Ayurvedic medicine to treat diseases such as anaemia, jaundice, constipation, asthma, fever and chronic ulcers. Anti-mutagenic effects of the polyphenolic fractions isolated from Triphala have been reported, thus indicating that the phenols present in the formulation might be responsible for its therapeutic efficacy.

Author(s): 
Singh, D. P.
Govindarajan, R.
Rawat, A. K. S.
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

The present study was carried out to study the effect of Butea monosperma, a known liver acting drug on the tumor promotion related events of carcinogenesis in rat liver. Thioacetamide (TAA) was used to induce tumor promotion response and oxidative stress and caused significant depletion in the detoxification and antioxidant enzyme armory with concomitant elevation in malondialdehyde (MDA) formation, hydrogen peroxide (H(2)O(2)) generation, ornithine decarboxylase (ODC) activity and unscheduled DNA synthesis. However, B.

Author(s): 
Sehrawat, A.
Khan, T. H.
Prasad, L.
Sultana, S.
Publication Title: 
Phytochemical analysis: PCA

Triphala is an anti-oxidant-rich herbal formulation containing fruits of Emblica officinalis, Terminalia chebula and T. belerica in equal proportions. The preparation is frequently used in Ayurvedic medicine to treat diseases such as anaemia, jaundice, constipation, asthma, fever and chronic ulcers. Anti-mutagenic effects of the polyphenolic fractions isolated from Triphala have been reported, thus indicating that the phenols present in the formulation might be responsible for its therapeutic efficacy.

Author(s): 
Singh, D. P.
Govindarajan, R.
Rawat, A. K. S.
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

An ethanolic extract of Russian tarragon, Artemisia dracunculus L., with antihyperglycemic activity in animal models was reported to decrease phosphoenolpyruvate carboxykinase (PEPCK) mRNA expression in STZ-induced diabetic rats. A quantitative polymerase chain reaction (qPCR) assay was developed for the bioactivity-guided purification of the compounds within the extract that decrease PEPCK expression. The assay was based on the inhibition of dexamethasone-stimulated PEPCK upregulation in an H4IIE hepatoma cell line.

Author(s): 
Govorko, Dmitry
Logendra, Sithes
Wang, Yanxin
Esposito, Debora
Komarnytsky, Slavko
Ribnicky, David
Poulev, Alexander
Wang, Zhong
Cefalu, William T.
Raskin, Ilya
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Activation of mast cells in rheumatoid synovial tissue has often been associated with tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8 production and disease pathogenesis by adjacent cell types. Butea monosperma (BM) is a well known medicinal plant in India and the tropics. The aim of this study was to examine whether a standardized extract of BM flower (BME) could inhibit inflammatory reactions in human mast cells (HMC) using activated HMC-1 cells as a model.

Author(s): 
Rasheed, Zafar
Akhtar, Nahid
Khan, Abubakar
Khan, Khursheed A.
Haqqi, Tariq M.
Publication Title: 
Phytotherapy research: PTR

Allergic asthma is associated with Th2-mediated inflammation. Several flavonoids were isolated from Glycyrrhiza uralensis, one of the herbs in the anti-asthma herbal medicine intervention. The aim of this investigation was to determine whether Glycyrrhiza uralensis flavonoids have inhibitory effects on memory Th2 responses in vitro and antigen-induced Th2 inflammation in vivo. The effects of three Glycyrrhiza uralensis flavonoids on effector memory Th2 cells, D10.G4.1 (D10 cells), were determined by measuring Th2 cytokine production.

Author(s): 
Yang, Nan
Patil, Sangita
Zhuge, Jian
Wen, Ming-Chun
Bolleddula, Jayaprakasam
Doddaga, Srinivasulu
Goldfarb, Joseph
Sampson, Hugh A.
Li, Xiu-Min
Publication Title: 
Journal of Agricultural and Food Chemistry

Bioactive components in food plants can undergo dynamic processes that involve multiple chemical species. For example, 2'-hydroxychalcones can readily isomerize into flavanones. Although chemically well documented, this reaction has barely been explored in the context of cell-based assays.

Author(s): 
Simmler, Charlotte
Hajirahimkhan, Atieh
Lankin, David C.
Bolton, Judy L.
Jones, Tristesse
Soejarto, Djaja D.
Chen, Shao-Nong
Pauli, Guido F.
Publication Title: 
PloS One

The increased cancer risk associated with hormone therapies has encouraged many women to seek non-hormonal alternatives including botanical supplements such as hops (Humulus lupulus) and licorice (Glycyrrhiza spec.) to manage menopausal symptoms. Previous studies have shown estrogenic properties for hops, likely due to the presence of 8-prenylnarigenin, and chemopreventive effects mainly attributed to xanthohumol. Similarly, a combination of estrogenic and chemopreventive properties has been reported for various Glycyrrhiza species.

Author(s): 
Hajirahimkhan, Atieh
Simmler, Charlotte
Yuan, Yang
Anderson, Jeffrey R.
Chen, Shao-Nong
Nikolic, Dejan
Dietz, Birgit M.
Pauli, Guido F.
van Breemen, Richard B.
Bolton, Judy L.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Tumor-induced angiogenesis is essential for invasive growth and hematogenous metastasis of adenoid cystic carcinoma (ACC), a highly aggressive neoplasm mostly occurring in salivary glands. Previous studies have indicated that strategies directed against angiogenesis will help develop new therapeutic agents for ACC. The Chinese folk medicine licorice has been used for years as a natural remedy for angiogenesis-related diseases.

Author(s): 
Sun, Zhi-Jun
Chen, Gang
Zhang, Wei
Hu, Xiang
Huang, Cong-Fa
Wang, Yu-Fan
Jia, Jun
Zhao, Yi-Fang
Publication Title: 
Molecular Pharmacology

Antiangiogenesis is a promising strategy of cancer treatment. Vascular endothelial growth factor receptor [fetal liver kinase/kinase-inserting domain-containing receptor (KDR)] is a tyrosine kinase receptor and has been strongly implicated in tumor angiogenesis.

Author(s): 
Zhu, Xiao-Feng
Xie, Bin-Fen
Zhou, Jun-Min
Feng, Gong-Kan
Liu, Zong-Chao
Wei, Xiao-Yi
Zhang, Feng-Xian
Liu, Mei-Fang
Zeng, Yi-Xin

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