Chelating Agents

Publication Title: 
Neuromolecular Medicine

A common cause of amyotrophic lateral sclerosis is mutations in superoxide dismutase-1, which provoke the disease by an unknown mechanism. We have previously found that soluble hydrophobic misfolded mutant human superoxide dismutase-1 species are enriched in the vulnerable spinal cords of transgenic model mice. The levels were broadly inversely correlated with life spans, suggesting involvement in the pathogenesis.

Author(s): 
Zetterstrˆm, Per
Graffmo, Karin S.
Andersen, Peter M.
Br‰nnstrˆm, Thomas
Marklund, Stefan L.
Publication Title: 
Ageing Research Reviews

In ageing, alterations in inflammatory/immune response and antioxidant capacity lead to increased susceptibility to diseases and loss of mobility and agility. Various essential micronutrients in the diet are involved in age-altered biological functions. Micronutrients (zinc, copper, iron) play a pivotal role either in maintaining and reinforcing the immune and antioxidant performances or in affecting the complex network of genes (nutrigenomic approach) involved in encoding proteins for a correct inflammatory/immune response.

Author(s): 
Mocchegiani, Eugenio
Costarelli, Laura
Giacconi, Robertina
Piacenza, Francesco
Basso, Andrea
Malavolta, Marco
Publication Title: 
Indian Journal of Medical Sciences

Lead poisoning following intake of Ayurvedic medication is one of the recent areas of concern. We report a case of a 58-year-old type II diabetic man who was stable with diet control and 30 mg pioglitazone per day. He took Ayurvedic medication for generalized weakness and developed peripheral neuropathy following its intake. He was found to have high blood and urinary lead levels and was diagnosed to have subacute lead poisoning. He was treated with d-Penicillamine for 8 weeks, following which his lead levels became normal.

Author(s): 
Singh, Surjit
Mukherjee, K. K.
Gill, K. D.
Flora, S. J. S.
Publication Title: 
Journal of Hematology & Oncology

Although the majority of published cases of lead poisoning come from occupational exposures, some traditional remedies may also contain toxic amounts of lead. Ayurveda is a system of traditional medicine that is native to India and is used in many parts of world as an alternative to standard treatment regimens. Here, we report the case of a 58-year-old woman who presented with abdominal pain, anemia, liver function abnormalities, and an elevated blood lead level. The patient was found to have been taking the Ayurvedic medicine Jambrulin prior to presentation.

Author(s): 
Gunturu, Krishna S.
Nagarajan, Priyadharsini
McPhedran, Peter
Goodman, Thomas R.
Hodsdon, Michael E.
Strout, Matthew P.
Publication Title: 
MMWR. Morbidity and mortality weekly report

Lead poisoning still occurs in the United States despite extensive prevention efforts and strict regulations. Exposure to lead can damage the brain, kidneys, and nervous and reproductive systems. Fetal exposure to lead can adversely affect neurodevelopment, decrease fetal growth, and increase the risk for premature birth and miscarriage. During 2011-2012, the New York City Department of Health and Mental Hygiene (DOHMH) investigated six cases of lead poisoning associated with the use of 10 oral Ayurvedic medications made in India.

Author(s): 
Centers for Disease Control and Prevention (CDC)
Publication Title: 
Alternative Therapies in Health and Medicine

CONTEXT: Removal of toxins from the body is an integral part of Ayurvedic, yogic, and naturopathic medicine. Symptoms of poor health in people free from diagnosed disease may be related to toxin buildup. OBJECTIVE: This study investigates whether a 7-day program of detoxification can improve well-being and enhance the activity of liver detoxification pathways. METHODS: In this pilot, patient-outcome-focused, noncontrolled clinical intervention, 25 disease-free participants were recruited.

Author(s): 
MacIntosh, A.
Ball, K.
Publication Title: 
Phytotherapy research: PTR

Alzheimer's disease is a neurodegenerative disorder characterized by progressive dementia. Bacopa monniera is described in the Ayurvedic Materia Medica, as a therapeutically useful herb for the treatment of cognitive impairment, thus supporting its possible anti-Alzheimer's properties. Our studies have shown that Bacopa monniera reduces beta-amyloid deposits in the brain of an Alzheimer's disease animal model.

Author(s): 
Dhanasekaran, Muralikrishnan
Tharakan, Binu
Holcomb, Leigh A.
Hitt, Angie R.
Young, Keith A.
Manyam, Bala V.
Publication Title: 
Phytotherapy research: PTR

Parkinson's disease is a neurodegenerative disorder for which no neurorestorative therapeutic treatment is currently available. Oxidative stress plays an important role in the pathophysiology of Parkinson's disease. The ancient Indian medical system, Ayurveda, traditionally uses Mucuna pruriens to treat Parkinson's disease. In our earlier studies, Mucuna pruriens has been shown to possess antiparkinson and neuroprotective effects in animal models of Parkinson's disease.

Author(s): 
Dhanasekaran, Muralikrishnan
Tharakan, Binu
Manyam, Bala V.
Publication Title: 
La Revue De Médecine Interne / Fondée ... Par La Société Nationale Francaise De Médecine Interne

INTRODUCTION: Current unusual environmental sources of lead exposure mainly include traditional medicines, either ayurvedic remedies or others, traditional cosmetics (kohl, surma), and the use of traditional earthenware, for storage or cooking. CASE REPORTS: We report two cases of lead poisoning in adults initially identified by paroxysmal abdominal pain or anemia.

Author(s): 
Sabouraud, S.
Coppéré, B.
Rousseau, C.
Testud, F.
Pulce, C.
Tholly, F.
Blanc, M.
Culoma, F.
Facchin, A.
Ninet, J.
Chambon, P.
Medina, B.
Descotes, J.
Publication Title: 
Indian Journal of Medical Sciences

Lead poisoning following intake of Ayurvedic medication is one of the recent areas of concern. We report a case of a 58-year-old type II diabetic man who was stable with diet control and 30 mg pioglitazone per day. He took Ayurvedic medication for generalized weakness and developed peripheral neuropathy following its intake. He was found to have high blood and urinary lead levels and was diagnosed to have subacute lead poisoning. He was treated with d-Penicillamine for 8 weeks, following which his lead levels became normal.

Author(s): 
Singh, Surjit
Mukherjee, K. K.
Gill, K. D.
Flora, S. J. S.

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