Chemistry, Pharmaceutical

Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

This paper considers the problem of evaluating multimodal integrative medicine treatments for complex pathologic conditions. The example is given of evaluation of highly successful treatments of lymphedema using Ayurvedic and Yoga medicine practices together with modern medicine. For a framework to evaluate such a complex intervention, we base our proposal on Consolidated Standards of Reporting Trials (CONSORT) guidelines.

Author(s): 
Narahari, Saravu R.
Ryan, Terence J.
Aggithaya, Madhur Guruprasad
Bose, Kuttaje S.
Prasanna, Kodimoole S.
Publication Title: 
Journal of Clinical Nursing

AIMS AND OBJECTIVES: This study sought to assess the impact of a standardized protocol to maintain nasoenteral tube (NET) patency in patients requiring fluid restriction and identify factors associated with tube patency. BACKGROUND: Nasoenteral tube obstruction may interrupt nutritional support and prohibit drug administration. Balancing NET patency in the context of fluid restriction can be a challenge. DESIGN AND METHODS: The impact of the standardized protocol was assessed by using a quasi-experimental design and an historical control.

Author(s): 
Matsuba, Claudia St
De Gutiérrez, Maria Gr
Whitaker, Iveth Y.
Publication Title: 
Complementary Therapies in Medicine

OBJECTIVE: Systematic assessment of the in vitro research on high potency effects. METHOD: Publications of experiments were collected through databases, experts, previous reviews, citation tracking. INCLUSION CRITERIA: stepwise agitated dilutions <10(-23); cells or molecules from human or animal. Experiments were assessed with the modified SAPEH score. RESULTS: From 75 publications, 67 experiments (1/3 of them replications) were evaluated. Nearly 3/4 of them found a high potency effect, and 2/3 of those 18 that scored 6 points or more and controlled contamination.

Author(s): 
Witt, Claudia M.
Bluth, Michael
Albrecht, Henning
Weisshuhn, Thorolf E. R.
Baumgartner, Stephan
Willich, Stefan N.
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: The Ayurvedic Pharmacopoeia of India (API) is a unique book of standards describing the quality, purity and strength of selected drugs that are manufactured, distributed, and sold by the licensed manufacturers in pan India. It is developed in two parts; the part one comprises of mono-monographs of medicinal substances of natural origin and part two includes selected compound formulations sourced from the schedule - I books under the Drugs and Cosmetics Act, 1940 comprising of popular Ayurvedic classics of different period of times.

Author(s): 
Joshi, Vinod Kumar
Joshi, Apurva
Dhiman, Kartar Singh
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

This paper considers the problem of evaluating multimodal integrative medicine treatments for complex pathologic conditions. The example is given of evaluation of highly successful treatments of lymphedema using Ayurvedic and Yoga medicine practices together with modern medicine. For a framework to evaluate such a complex intervention, we base our proposal on Consolidated Standards of Reporting Trials (CONSORT) guidelines.

Author(s): 
Narahari, Saravu R.
Ryan, Terence J.
Aggithaya, Madhur Guruprasad
Bose, Kuttaje S.
Prasanna, Kodimoole S.
Publication Title: 
Journal of Ethnopharmacology

The activity of a crude extract formulation was evaluated in experimental amoebic liver abscess in golden hamsters and in immunomodulation studies. The formulation comprises the following five plants-Boerhavia diffusa, Tinospora cordifolia, Berberis aristata, Terminalia chebula and Zingiber officinale. The formulation had a maximum cure rate of 73% at a dose of 800 mg/kg/day in hepatic amoebiasis reducing the average degree of infection (ADI) to 1.3 as compared to 4.2 for sham-treated controls.

Author(s): 
Sohni, Y. R.
Bhatt, R. M.
Publication Title: 
The Journal of Contemporary Dental Practice

AIM: Many weapons are available in the arsenal of a dental professional to combat dental caries, which is almost ubiquitously present. From a public health perspective, most of these weapons are far from being an ideal drug. Hence, there is a demand for better and effective antibacterial agents. This factor stimulated the process of the present study. The aim of the study was to determine the effect of ethanol extract of Terminalia chebula on Streptococcus mutans. MATERIALS AND METHODS: Dried ripe fruits of Terminalia chebula were procured and powdered.

Author(s): 
Nayak, Sushma S.
Ankola, Anil V.
Metgud, Sharda C.
Bolmal, Uday Kumar
Publication Title: 
Trends in Pharmacological Sciences

Acetylation of chromatin-interacting proteins is central to the epigenetic regulation of genome architecture and gene expression. Chemicals that modulate the acetylation of nuclear proteins have proved instrumental in experimental models of several human diseases. Sirtuins represent a new class of evolutionary conserved histone deacetylases, originally identified in yeast, that have emerging pathogenetic roles in cancer, diabetes, muscle differentiation, heart failure, neurodegeneration and aging.

Author(s): 
Porcu, Marco
Chiarugi, Alberto
Publication Title: 
Nature Medicine
Author(s): 
Willyard, Cassandra
Publication Title: 
Current Medicinal Chemistry

The pronounced effects of the epigenetic diet (ED) and caloric restriction (CR) have on epigenetic gene regulation have been documented in many pre-clinical and clinical studies. Understanding epigenetics is of high importance because of the concept that external factors such as nutrition and diet may possess the ability to alter gene expression without modifying the DNA sequence. The ED introduces bioactive medicinal chemistry compounds such as sulforaphane (SFN), curcumin (CCM), epigallocatechin gallate (EGCG) and resveratrol (RSV) that are thought to aid in extending the human lifespan.

Author(s): 
Martin, S. L.
Hardy, T. M.
Tollefsbol, T. O.

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