Chemokine CCL2

Publication Title: 
Clinical chemistry and laboratory medicine: CCLM / FESCC

BACKGROUND: Aging is associated with low-grade elevation of circulating inflammatory markers, leading to increased risk of morbidity and mortality. The Mediterranean diet has been suggested as a determinant of longevity. In the current study, we investigated the impact of the Mediterranean diet on inflammatory status in old subjects. METHODS: Within the ZINCAGE study, 957 healthy old subjects (>or=60 years old) from five European countries were recruited.

Author(s): 
Dedoussis, George V.
Kanoni, Stavroula
Mariani, Erminia
Cattini, Luca
Herbein, Georges
Fulop, Tamas
Varin, Audrey
Rink, Lothar
Jajte, Jolanta
Monti, Daniela
Marcellini, Fiorela
Malavolta, Marco
Mocchegiani, Eugenio
Publication Title: 
International Journal of Obesity (2005)

OBJECTIVE: With the increasing rates of obesity, many people diet in an attempt to lose weight. As weight loss is seldom maintained in a single effort, weight cycling is a common occurrence. Unfortunately, reports from clinical studies that have attempted to determine the effect of weight cycling on mortality are in disagreement, and to date, no controlled animal study has been performed to assess the impact of weight cycling on longevity.

Author(s): 
List, E. O.
Berryman, D. E.
Wright-Piekarski, J.
Jara, A.
Funk, K.
Kopchick, J. J.
Publication Title: 
Cellular & Molecular Immunology

Recent evidence indicates that artesunate has immunomodulatory properties that might be useful for treating autoimmune disease. In this study, we conducted a pilot study and explored the effect and mechanism of artesunate on the treatment of systemic lupus erythematosus using an MRL/lpr murine model. MRL/lpr mice were divided into control, cyclophosphamide (CTX) and artesunate treatment groups. Blood was collected to measure serum levels of creatinine, antinuclear antibody (ANA) and anti-double-stranded DNA (anti-dsDNA) antibody.

Author(s): 
Jin, Ouyang
Zhang, Huayong
Gu, Zhifeng
Zhao, Shengnan
Xu, Ting
Zhou, Kangxing
Jiang, Bo
Wang, Jie
Zeng, Xiaofeng
Sun, Lingyun
Publication Title: 
American Journal of Respiratory Cell and Molecular Biology

Quercetin (3,3',4',5,7-pentahydroxyflavone), a dietary flavonoid, is an inhibitor of phosphatidylinositol (PI) 3-kinase and potent antioxidant. We hypothesized that quercetin blocks airway epithelial cell chemokine expression via PI 3-kinase-dependent mechanisms. Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells.

Author(s): 
Nanua, Suparna
Zick, Suzanna M.
Andrade, Juan E.
Sajjan, Umadevi S.
Burgess, John R.
Lukacs, Nicholas W.
Hershenson, Marc B.
Publication Title: 
American Journal of Physiology. Endocrinology and Metabolism

The extract of plant Shilianhua (SLH; Sinocrassula indica Berge) is a component in a commercial product for control of blood glucose. However, it remains to be investigated whether the SLH extract enhances insulin sensitivity in a model of type 2 diabetes. To address this question, the SLH crude extract was fractionated into four parts on the basis of polarity, and bioactivities of each part were tested in cells. One of the fractions, F100, exhibited a strong activity in the stimulation of glucose consumption in vitro.

Author(s): 
Yin, Jun
Zuberi, Aamir
Gao, Zhanguo
Liu, Dong
Liu, Zhijun
Ye, Jianping
Publication Title: 
International Journal of Oncology

Expression and activity of CC motif ligand 2 (CCL2) is down-regulated by curcumin, the active phytochemical ingredient of turmeric (Curcuma longa), a dietary supplement often self-prescribed to promote prostate health. CCL2 is a potent chemotactic factor of prostate cancer (PCa) with important roles in development of bone metastasis. The relationship between CCL2 and curcumin, however, has not been studied in PCa. Adhesion, invasion and motility of PC-3 cells were measured in response to exposure to curcumin (30 microM; 18 h), CCL2 (100 ng/ml; 18 h) or PMA (100 ng/ml; 18 h).

Author(s): 
Herman, Jeffery G.
Stadelman, Henry L.
Roselli, Charles E.
Publication Title: 
Inflammatory Bowel Diseases

BACKGROUND: Bacteria play a role in inflammatory bowel disease and other forms of intestinal inflammation. Although much attention has focused on the search for a pathogen or inciting inflammatory bacteria, another possibility is a lack of beneficial bacteria that normally confer anti-inflammatory properties in the gut. The purpose of this study was to determine whether normal commensal bacteria could inhibit inflammatory pathways important in intestinal inflammation.

Author(s): 
Petrof, Elaine O.
Claud, Erika C.
Sun, Jun
Abramova, Tatiana
Guo, Yuee
Waypa, Tonya S.
He, Shu-Mei
Nakagawa, Yasushi
Chang, Eugene B.
Publication Title: 
Endocrinology

Toll-like receptors (TLRs) are key innate immune sensors of endogenous damage signals and play an important role in inflammatory diseases like diabetes and atherosclerosis. Pioglitazone (PIO), a peroxisome proliferator-activated receptor (PPAR)-gamma agonist, has been reported to be an antiinflammatory agent. Thus, in the present study, we examined the antiinflammatory effects of PIO on TLR2 and TLR4 expression in human monocytes exposed to Pam3CSK4 (Pam; TLR2 ligand) and purified lipopolysaccharide (LPS; TLR4 ligand) using flow cytometry and real-time RT-PCR.

Author(s): 
Dasu, Mohan R.
Park, Samuel
Devaraj, Sridevi
Jialal, Ishwarlal
Publication Title: 
The American Journal of Pathology

In this study we observed that mice pretreated with tumor exosomes had a significant acceleration of tumor metastasis in the lung. Tumor metastasis correlated significantly with an increase in recruitment of more Myeloid-derived suppressor cells (MDSCs) in the lung of C57BL/6j (B6) mice pretreated with tumor exosomes. These effects were blunted when MyD88 knockout (KO) mice were pretreated with tumor exosomes.

Author(s): 
Liu, Yuelong
Xiang, Xiaoyu
Zhuang, Xiaoying
Zhang, Shuangyin
Liu, Cunren
Cheng, Ziqiang
Michalek, Sue
Grizzle, William
Zhang, Huang-Ge
Publication Title: 
Experimental Biology and Medicine (Maywood, N.J.)

Vascular inflammation and monocyte recruitment are initiating events in atherosclerosis that have been suggested to be caused, in part, by iron-mediated oxidative stress and shifts in the intracellular redox environment of vascular cells. Therefore, the objective of this study was to investigate whether the intracellular iron chelator, desferrioxamine (DFO), reduces inflammation and atherosclerosis in experimental mice.

Author(s): 
Zhang, Wei-Jian
Wei, Hao
Frei, Balz

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