Cholestanones

Publication Title: 
Journal of Medicinal Chemistry

Brassinosteroids are plant-derived polyhydroxylated derivatives of 5α-cholestane, structurally similar to cholesterol-derived animal steroid hormones and insect ecdysteroids.

Author(s): 
Esposito, Debora
Rathinasabapathy, Thirumurugan
Poulev, Alexander
Komarnytsky, Slavko
Raskin, Ilya
Publication Title: 
FASEB journal: official publication of the Federation of American Societies for Experimental Biology

Brassinosteroids are plant-derived polyhydroxylated derivatives of 5a-cholestane, structurally similar to cholesterol-derived animal steroid hormones and insect ecdysteroids, with no known function in mammals. 28-Homobrassinolide (HB), a steroidal lactone with potent plant growth-promoting property, stimulated protein synthesis and inhibited protein degradation in L6 rat skeletal muscle cells (EC(50) 4 μM) mediated in part by PI3K/Akt signaling pathway.

Author(s): 
Esposito, Debora
Komarnytsky, Slavko
Shapses, Sue
Raskin, Ilya
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